Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy [0.03%]
从系统发生古老的鱼类中获得的胰高血糖素相关多肽发现了开发治疗二型糖尿病的靶向GCGR和GLP1R激动剂的新方法
Galyna V Graham,J Michael Conlon,Yasser H Abdel-Wahab et al.
Galyna V Graham et al.
The insulinotropic and antihyperglycaemic properties of glucagons from the sea lamprey (Petromyzontiformes), paddlefish (Acipenseriformes) and trout (Teleostei) and oxyntomodulin from dogfish (Elasmobranchii) and ratfish (Holocephali) were ...
Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats [0.03%]
orexin受体拮抗剂对海马内阿片复吸的抑制作用及其与可塑性标志物的关系
Mirmohammadali Mirramezani Alizamini,Mohadeseh Kavianpour,Saeideh Karimi-Haghighi et al.
Mirmohammadali Mirramezani Alizamini et al.
It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine-induced CPP is a common method to consider motivational properti...
Expression of neuropeptide Y and gonadotropin-releasing hormone gene types in the brain of female Nile tilapia (Oreochromis niloticus) during mouthbrooding and food restriction [0.03%]
尼罗河罗非鱼（Oreochromis niloticus）育儿和饥饿期间大脑神经肽Y和促性腺激素释放激素基因类型的表达
Kalpana Das,Satoshi Ogawa,Takashi Kitahashi et al.
Kalpana Das et al.
A cichlid fish, the Nile tilapia (Oreochromis niloticus), is a maternal mouthbrooder, which exhibits minimum energy expenditure and slower ovarian cycles during mouthbrooding. The objective of this study was to observe changes in the gene e...
RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders [0.03%]
RAMP3缺乏加重绝经后肥胖和代谢紊乱
Teng Liu,Akiko Kamiyoshi,Megumu Tanaka et al.
Teng Liu et al.
There is a marked increase in the incidence of visceral adiposity and insulin resistance among women following menopause. Adrenomedullin (AM) is an endogenous peptide first identified as a vasodilator, but now known to exert a variety of ph...
BJ-PRO-7A and BJ-PRO-10C induce vasodilatation and inotropic effects in normotensive and hypertensive rats: Role of nitric oxide and muscarinic receptors [0.03%]
BJ-PRO-7A和BJ-PRO-10C通过硝酸盐和毒蕈碱受体诱发血管舒张及正性肌力作用：正常血压与高血压大鼠模型中的作用机制研究
A D C Nunes,P H Alves,E P Mendes et al.
A D C Nunes et al.
Bj-PRO-7a and Bj-PRO-10c belong to a family of proline-rich oligopeptides (PROs) identified in Bothrops jararaca (Bj) crude venom. Previous studies have shown an antihypertensive effect evoked by theses peptides. However, the mechanisms und...
Takashi Miyauchi,Satoshi Sakai
Takashi Miyauchi
Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a potent vasoconstrictor and pressor substance isolated from the culture supernatant of porcine aortic endothelial cells. From human genomic DNA analysis, two...
Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies [0.03%]
从临床病例研究角度理解亲吻肽和亲吻肽受体（Kiss1R）的功能
Ran Ke,Xin Ma,Leo T O Lee
Ran Ke
It is widely acknowledged that kisspeptin and its receptor Kiss1R play central regulatory roles in the hypothalamus-pituitary-gonad (HPG) axis and reproduction. Mutations of KISS1 and KISS1R lead to disorders associated with pubertal develo...
Kazuhiro Takahashi,Karl-Heinz Herzig
Kazuhiro Takahashi
The host defense peptide LL-37 triggers release of nucleic acids from human mast cells [0.03%]
宿主防御肽LL-37触发人类肥大细胞释放核酸
Sara Dahl,Emma Anders,Olof Gidlöf et al.
Sara Dahl et al.
The human host defense peptide LL-37 possesses antimicrobial activity but also affects host cell function and viability. Mast cells are involved in innate immunity but no data have been presented on effects of LL-37 on human mast cell viabi...
PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner [0.03%]
PAC1通过依赖反应性氧介导受体酪氨酸激酶的侧向激活
Terry W Moody,Lingaku Lee,Tatiana Iordanskaia et al.
Terry W Moody et al.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a growth factor for lung cancer cells. PACAP-27 or PACAP-38 binds with high affinity to non-small cell lung cancer (NSCLC) cells, causing elevated cytosolic Ca2+, increased proli...