Exploiting endogenous opioids: Lessons learned from endomorphin 2 in the female rat [0.03%]
内源性鸦片类物质的利用——来自雌鼠内吗啡肽2的研究启示
Alan R Gintzler,Nai-Jiang Liu,Emiliya M Storman et al.
Alan R Gintzler et al.
Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concern...
Epinecidin-1: A marine fish antimicrobial peptide with therapeutic potential against Trichomonas vaginalis infection in mice [0.03%]
epinecidin-1：一种具有治疗小鼠阴道毛滴虫感染潜力的海洋鱼抗菌肽
Han-Ning Huang,Chi-Mu Chuang,Jyh-Yih Chen et al.
Han-Ning Huang et al.
Trichomoniasis is caused by infection with the protozoan parasite Trichomonas vaginalis, and prolonged persistence may lead to serious ill effects in patients. Thus, the development of new therapeutic strategies to combat drug-resistant T. ...
NOP agonist action of cebranopadol counteracts its liability to promote physical dependence [0.03%]
阿西博诺痛觉调节剂通过激活NOP受体来缓解机体对该药产生依赖性的问题
Chiara Ruzza,Victor A Holanda,Elaine C Gavioli et al.
Chiara Ruzza et al.
Cebranopadol is a mixed NOP/opioid receptor agonist currently under development as innovative analgesic. In this study the liability of cebranopadol to produce opioid-type physical dependence has been evaluated in comparison with morphine i...
Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival [0.03%]
小鼠遗传性前肾上腺髓质素N端二十肽(PAMP)缺失不影响存活
Brooke C Matson,Manyu Li,Claire E Trincot et al.
Brooke C Matson et al.
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also...
Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models [0.03%]
兰索氨酸稳定血管紧张素-(1-7)在I型和II型糖尿病小鼠模型中的疗效研究
Anneke Kuipers,Gert N Moll,Elizabeth Wagner et al.
Anneke Kuipers et al.
Native angiotensin-(1-7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), which is fully resis...
Karl-Heinz Herzig
Karl-Heinz Herzig
Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway [0.03%]
利拉鲁肽通过抑制NF-κB信号途径抑制AGEs诱导的大冠状动脉平滑肌细胞表型转化
Beibing Di,Hong-Wei Li,Weiping Li et al.
Beibing Di et al.
Vascular smooth muscle cell (VSMC) phenotype transition is involved in diabetes-associated cardiovascular diseases. The mechanism of VSMCs phenotypic transition in T2DM was still unclear. Rat coronary artery SMCs were pretreated with liragl...
Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides [0.03%]
新型nociceptin/OFQ类似物和N/OFQ-RYYRIK杂交肽的生化和药理学研究
Anna I Erdei,Adina Borbély,Anna Magyar et al.
Anna I Erdei et al.
The endogenous ligand nociceptin (N/OFQ) and a positively charged synthetic peptide RYYRIK are both selective for the nociceptin opioid receptor (NOPr). Despite their structural dissimilarity, N/OFQ and RYYRIK compete for the same binding s...
Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle [0.03%]
GLP-1受体在结肠平滑肌中的鉴定及其表达和功能研究
Alexander T May,Molly S Crowe,Bryan A Blakeney et al.
Alexander T May et al.
The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach and intestine which involves bo...
High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs [0.03%]
ANP和BNP的大剂量给药加剧人类脂解作用，BNP的脂解作用与猪心脏甘油三酯含量相关
Emil D Bartels,Song Guo,Birgitte S Kousholt et al.
Emil D Bartels et al.
Drugs facilitating the cardioprotective effects of natriuretic peptides are introduced in heart failure treatment. ANP and BNP also stimulate lipolysis and increase circulating concentrations of free fatty acids (FFAs); an aspect, however, ...