Validation of antibody-based assays for regulatory peptides: Do it once, get it right, and exploit the under-appreciated benefit of long-term antibody stability [0.03%]
基于抗体的监管肽测定方法验证：一次性做好，充分利用长期稳定的抗体被忽视的优势
Graham Dockray
Graham Dockray
Many submitted manuscripts utilizing antibody-based assays for biologically active peptides frequently neither include nor cite adequate validation data with the risk that the report is adding to the reproducibility crisis in biological res...
Fungi-derived lipopeptide antibiotics developed since 2000 [0.03%]
2000年以来发现的 fungal 次生代谢产物脂肽抗生素类家族及其功能研究进展
Pengchao Zhao,Yun Xue,Xin Li et al.
Pengchao Zhao et al.
Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails linked to the N-terminus of a short oligopeptide that may be chemically modified and/or contain unusual amino acid residues in their structures. The...
Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells [0.03%]
下丘脑食欲素A通过调节骨形态发生蛋白4对催乳素的分泌调控作用于大鼠泌乳素细胞体外研究
Satoshi Fujisawa,Motoshi Komatsubara,Kanako Ogura-Ochi et al.
Satoshi Fujisawa et al.
The impact of orexins on anterior pituitary function has yet to be clarified. We studied the effects of orexin A and its interaction with the bone morphogenetic protein (BMP) system on the regulatory role of prolactin synthesis using rat la...
The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans [0.03%]
人血浆和脑脊液中年龄和性别对irisin水平影响的研究
Qingwei Ruan,Yun Huang,Lvjun Yang et al.
Qingwei Ruan et al.
Background: Adipo-myokine irisin has important effects on the metabolism and functioning of multiple tissues and organs. However, the effects of aging and sex on irisin levels in cerebrospinal fluid (CSF) and on circulati...
The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract [0.03%]
L细胞转录组不受垂直胃大部切除术的影响，但很大程度上依赖于在消化道中的位置
Katherine A Rollins,Lennart Opitz,Myrtha Arnold et al.
Katherine A Rollins et al.
Altered GLP-1 secretion from L cells has been implicated in the development of type 2 diabetes mellitus and its resolution following bariatric surgery. However, changes in L cell gene expression, which may form the basis for altered functio...
Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion [0.03%]
化皮分泌物中三种具有免疫调节活性的宿主防御肽AC12、DK16和RC11
Cláudia S F C Popov,Beatriz Simas Magalhães,Brian James Goodfellow et al.
Cláudia S F C Popov et al.
Inflammation is a natural defense mechanism of the immune system; however, when unregulated, it can lead to chronic illness. Glucocorticoids are the most commonly used agents to effectively treat inflammatory conditions, including autoimmun...
Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat [0.03%]
甲亢和甲减对雄性大鼠下丘脑内皮肽EI神经元与酪氨酸羟化酶神经元联系方式重建的不同影响
Carolina Ayala,Gisela E Pennacchio,Marta Soaje et al.
Carolina Ayala et al.
The Neuropeptide EI (NEI, glutamic acid- isoleucine amide) participates in neuroendocrine function. Previously we demonstrated that NEI concentration is regulated by thyroid hormones in discrete hypothalamic areas in rats. We observed that ...
The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii [0.03%]
奈伯739对多种抗生素耐药的大肠杆菌、肺炎克雷伯氏菌和鲍曼不动杆菌具有协同作用
Jonathan M Tyrrell,Ali F Aboklaish,Timothy R Walsh et al.
Jonathan M Tyrrell et al.
The antibiotic crisis has reinstated polymyxins, once abandoned because of their toxicity. Now, preclinical studies have revealed better tolerated and more effective derivatives of polymyxins such as NAB739. Simultaneously, polymyxin-resist...
Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats [0.03%]
超氧阴离子调节阿皮林在高血压病大鼠室旁核对交感神经活动及血压的作用
Yuewu Zhao,Yong Li,Zhengzhang Li et al.
Yuewu Zhao et al.
The present study was designed to determine how apelin in paraventricular nucleus (PVN) modulates the renal sympathetic nerve activity (RSNA), arterial blood pressure (ABP), mean arterial pressure (MAP), and heart rate (HR), and whether sup...
Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats [0.03%]
中央给药的kisspeptin通过公大鼠的nesfatin-1和缩宫素抑制进食
Reiko Saito,Kentaro Tanaka,Haruki Nishimura et al.
Reiko Saito et al.
Kisspeptin (KP), known as a hypothalamic neuropeptide, plays a critical role in the regulation of not only reproduction but also food intake. The anorectic neuropeptides, nesfatin-1 and oxytocin (OXT), are expressed in central nervous syste...