The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein [0.03%]
来自Tob1蛋白的短肽及其作为胰岛素促分泌剂的应用发现
Rina Nakamura,Motomi Konishi,Masanari Taniguchi et al.
Rina Nakamura et al.
We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JA...
Satellite symposium of to the 13th international symposium on VIP, PACAP and related peptides in Macau [0.03%]
第十三届VIP、PACAP及相关肽国际研讨会卫星会议（澳门）
Leo Tsz On Lee
Leo Tsz On Lee
Inflammatory mediators of opioid tolerance: Implications for dependency and addiction [0.03%]
阿片类药物耐受性的炎性介质：对依赖和成瘾的意义
Lori N Eidson,Anne Z Murphy
Lori N Eidson
Each year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, pr...
Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6 [0.03%]
由β-珠蛋白衍生的九肽LVV-H6诱发的行为效应
Kellen Rosa da Cruz,Danielle Ianzer,Larissa Córdova Turones et al.
Kellen Rosa da Cruz et al.
LVV-hemorphin-6 (LVV-h6) is bioactive peptide and is a product of the degradation of hemoglobin. Since LVV-h6 effects are possibly mediated by opioid or AT4/IRAP receptors, we hypothesized that LVV-h6 would modify behavior. We evaluated whe...
Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch [0.03%]
东亚钳蝎蝎毒中具有药用开发前景的活性多肽研究进展
Zhongjie Li,Ping Hu,Wenlan Wu et al.
Zhongjie Li et al.
The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the pept...
Enkephalin related peptides are released from jejunum wall by orally ingested bromelain [0.03%]
口服菠萝蛋白酶可释放出十二指肠壁中的脑啡肽相关多肽类物质
Paulo Eduardo Orlandi-Mattos,Rodrigo Barbosa Aguiar,Itabajara da Silva Vaz Junior et al.
Paulo Eduardo Orlandi-Mattos et al.
Stem bromelain [EC 3.4.22.32] is a thiol-endopeptidase and orally recommended in traditional medicine due to its analgesic activity, but the mechanisms are not known. Proenkephalin is expressed in the nervous system, but also in the gastroi...
Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett's esophagus [0.03%]
Trefoil因子家族多肽在胃食管反流病及巴雷特食管中可能的应用
Adam Fabisiak,Adrian Bartoszek,Grzegorz Kardas et al.
Adam Fabisiak et al.
Gastroesophageal reflux disease (GERD) is a chronic disorder of the digestive tract characterised mainly by a heartburn. Being one of the most common gastrointestinal diseases, the prevalence of GERD reaches up to 25.9% in Europe. Barrett's...
Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress [0.03%]
copeptin与胰岛素抵抗的关系：青春期和心理压力的影响作用
Camilla F Thomsen,Rasmus Dreier,Tina S Goharian et al.
Camilla F Thomsen et al.
In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young ...
Clinical Trial
Peptides. 2019 May:115:8-14. DOI:10.1016/j.peptides.2019.02.005 2019
Manju S Devi,R B Sashidhar
Manju S Devi
Aflatoxins are potent carcinogenic mycotoxins produced as secondary metabolites mainly by the fungi Aspergillus flavus and Aspergillus parasiticus. Control measures to curtail the contamination of aflatoxin in food products is still a chall...
Microinjection of 26RFa, an endogenous ligand for the glutamine RF-amide peptide receptor (QRFP receptor), into the rostral ventromedial medulla (RVM), locus coelureus (LC), and periaqueductal grey (PAG) produces an analgesic effect in rats [0.03%]
内源性配体26RFa作用于延髓腹侧背内侧区、导水管周围灰质和中脑导枕核的谷氨酰胺相关rfamide受体产生镇痛效应
Koji Yoshida,Takahiro Nonaka,Shingo Nakamura et al.
Koji Yoshida et al.
26RFa is an endogenous ligand for the QRFP receptor. We previously found that intracerebroventricular injection of 26RFa produces an analgesic effect in a rat formalin test. In the present study, we directly tested the hypothesis that the a...