Osteopontin-derived synthetic peptide SVVYGLR has potent utility in the functional regeneration of oral and maxillofacial skeletal muscles [0.03%]
衍生自骨连蛋白的合成肽SVVYGLR在口腔和颌面部骨骼肌功能再生中的强大效用
Susumu Tanaka,Yutaka Matsushita,Yoshinosuke Hamada et al.
Susumu Tanaka et al.
Oral and maxillofacial skeletal muscles are critical for oral motor functions, and severe damage to these muscles by trauma or surgery may lead to persistent functional impairment. This study investigated the effects of SVVYGLR (SV) peptide...
BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats [0.03%]
新型长效胰岛素肽类似物BZ043可减少链脲佐菌素致糖尿病大鼠的胃排空、摄食量、血糖和胰岛素需求量
Caio Victor M F Nascimento,Celimar Sinezia,Thayna Sisnande et al.
Caio Victor M F Nascimento et al.
Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. Here we describe a novel n-terminal PEGylated human amylin analog - BZ043 -...
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice [0.03%]
鸟苷酸环化酶/利钠原肽受体A基因缺陷上调（-pro）肾素受体在Npr1基因敲除小鼠肾脏中的表达
Ramu Periyasamy,Subhankar Das,Kailash N Pandey
Ramu Periyasamy
The objective of the present study was to determine whether targeted-disruption of Npr1 gene (encoding for guanylyl cyclase/natriuretic peptide receptor-A; GC-A/NPRA) upregulates pro(renin) receptor (P)RR expression and leads to the activat...
Nesfatin-1: A novel regulatory peptide associated with acute myocardial infarction and Mediterranean diet [0.03%]
新颖的调节肽nesfatin-1与急性心肌梗死和地中海饮食有关
Aliye Kuyumcu,Mevlut Serdar Kuyumcu,Mustafa Bilal Ozbay et al.
Aliye Kuyumcu et al.
We evaluated the relationship between nesfatin-1 and acute myocardial infarction (AMI) and Mediterranean diet scores. 67 patients with AMI and 33 patients with normal coronary arteries (control group) were included in the study. The patient...
Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway [0.03%]
Elabela通过与PI3K/Akt/mTOR通路结合保护链脲佐霉素诱导的糖尿病小鼠足细胞损伤
Yixian Zhang,Yangwei Wang,Manyu Luo et al.
Yixian Zhang et al.
Diabetic nephropathy is a common complication of diabetes characterized by an increased rate of protein excretion in urine and kidney function loss. Elabela is a newly discovered peptide whose role in the regulation of diabetes is the major...
Peptide conjugates of lactoferricin analogues and antimicrobials-Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity [0.03%]
类乳铁蛋白肽类似物和抗菌肽共轭物的设计、化学合成及其抗菌活性与哺乳动物细胞毒性的评价
Natalia Ptaszyńska,Katarzyna Olkiewicz,Joanna Okońska et al.
Natalia Ptaszyńska et al.
Eight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and one of the three antimicrobials - ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) - were synthesized. Four different link...
The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats [0.03%]
阿普林-13对实验性2型糖尿病大鼠胰岛β细胞量及心肌脂肪酸和葡萄糖代谢的影响
Jinghui Feng,Hang Zhao,Mengze Du et al.
Jinghui Feng et al.
Apelin, a new identified adipokine, and its G protein-coupled receptor named APJ are widely expressed in various tissues. Apelin has been found to play important roles in the physiopathology of multiple diseases. Our aim is to assess the ef...
The influence of high fat diet on plasma incretins and insulin concentrations in Sprague-Dawley rats with diet-induced obesity and glucose intolerance undergoing ileal transposition [0.03%]
高脂饮食对糖尿病外科手术荷瘤肥胖SD大鼠血浆肠泌素及胰岛素浓度的影响
Tomasz Sawczyn,Dominika Stygar,Katarzyna Nabrdalik et al.
Tomasz Sawczyn et al.
Background: The benefits of IT surgery are based on incretin effects. In this study we show the influence of high fat diet (HFD) used both before and after surgery, on ileal transposition (IT) effects. ...
Martha A Schalla,Andreas Stengel
Martha A Schalla
The recently discovered peptide phoenixin was initially implicated in reproduction as a regulator of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release from the pituitary. Subsequently, various functions of ph...
Neurokinin-1 receptor antagonist decreases [Ca2+]i in airway smooth muscle cells by reducing the reverse-mode Na+/Ca2+ exchanger current [0.03%]
神经激肽受体拮抗剂通过减少反向模式钠/钙交换电流来降低气道平滑肌细胞内游离钙离子浓度
Miao Li,Yun-Xiao Shang
Miao Li
Airway smooth muscle (ASM) is involved in asthma airway inflammation. The aim of this study was to evaluate the effect of substance P and neurokinin-1 receptor (NK-1R) antagonist on intracellular calcium concentration ([Ca2+]i) in airway sm...