Apelin-13 attenuates motor impairments and prevents the changes in synaptic plasticity-related molecules in the striatum of Parkinsonism rats [0.03%]
阿普林-13减轻帕金森病模型大鼠运动障碍及纹状体内可塑性相关分子的改变
Elham Haghparast,Vahid Sheibani,Mehdi Abbasnejad et al.
Elham Haghparast et al.
The striatum plays a critical role in motor control and also learning and memory of motor skills. It has been reported that striatal synaptic components are significantly decreased in dopaminergic-denervated striatum. In this study the effe...
Allison B Reiss,Daniel S Glass,Eric Lam et al.
Allison B Reiss et al.
Cardiovascular disease (CVD) remains the leading cause of death worldwide, despite multiple treatment options. In addition to elevated lipid levels, oxidative stress and inflammation are key factors driving atherogenesis and CVD. New strate...
Opioid addiction [0.03%]
阿片类药物成瘾
Richard J Bodnar
Richard J Bodnar
Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction [0.03%]
内源性阿片肽对摄食和体重的调节作用及其对动机和成瘾的影响
Richard J Bodnar
Richard J Bodnar
This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulate...
Molecular evolution of CRH and CRHR subfamily before the evolutionary origin of vertebrate [0.03%]
脊椎动物起源前的CRH和CRHR亚家族分子进化历程研究
Jason Sai Wun On,Aloysius Wilfred Raj Arokiaraj,Billy Kwok Chong Chow
Jason Sai Wun On
Corticotropin-releasing hormone (CRH) is well-cited for its important role in governing the stress responses via neuroendocrine system in vertebrates. After the identification of homologs of CRH receptor (CRHR) in both deuterostome and arth...
Decreased synovial fluid pituitary adenylate cyclase-activating polypeptide (PACAP) levels may reflect disease severity in post-traumatic knee osteoarthritis after anterior cruciate ligament injury [0.03%]
膝关节骨关节炎患者滑液中PACAP水平降低可能反映了疾病的严重程度：一项关于前交叉韧带损伤后的研究
Bing-Yin Sun,Zheng-Ping Sun,Zu-Cai Pang et al.
Bing-Yin Sun et al.
Background: It has been demonstrated that anterior cruciate ligament (ACL) injury-induced cartilage degeneration is the key risk factor for post-traumatic knee osteoarthritis (PTKOA).Pituitary adenylate cyclase-activating...
Crustacean hyperglycemic hormone (CHH) affects hemocyte intracellular signaling pathways to regulate exocytosis and immune response in white shrimp Litopenaeus vannamei [0.03%]
甲壳动物胰岛素/类胰岛素超家族激素(CHH)通过影响对虾血细胞内信号转导来调节胞外分泌及免疫应答
Lijun Xu,Luqing Pan,Xin Zhang et al.
Lijun Xu et al.
Recombinant Litopenaeus vannamei CHH (rLvCHH) was obtained from a bacterial expression system and the intracellular signaling pathways involved in exocytosis and immune response after rLvCHH injection (0.2 and 2 μg/shrimp) was investigated...
Anti-CGRP and anti-CGRP receptor monoclonal antibodies as antimigraine agents. Potential differences in safety profile postulated on a pathophysiological basis [0.03%]
作用于CGRP和CGRP受体的单克隆抗体作为抗偏头痛药物的潜力及基于病理生理学假说的安全性差异
Giuseppe Tringali,Pierluigi Navarra
Giuseppe Tringali
Calcitonin gene-related peptide (CGRP) is a peptide neurotransmitter with potent vasodilating properties. CGRP is believed to play a primary role in the pathogenesis of migraine. As such, CGRP and its receptors are obvious druggable targets...
Glucoregulatory activity of vesiculin in insulin sensitive and resistant mice [0.03%]
vesiculin在胰岛素敏感和耐受小鼠中的血糖调节活性
Kate L Lee,Jacqueline F Aitken,Huai-L Hsu et al.
Kate L Lee et al.
Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides hav...
Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction [0.03%]
用于止痛且无毒副作用和成瘾性的多价肽和肽模拟配体
Victor J Hruby
Victor J Hruby
The current opioid crisis has created a tragic problem in medicine and society. Pain is the most ubiquitous and costly disease in society and yet all of our "treatments" have toxicities, especially for prolonged use. However, there are seve...