Circulating levels of lipocalin-2 are associated with fatty pancreas but not fatty liver [0.03%]
脂蛋白相关素-2的循环水平与脂肪性胰腺而非脂肪肝有关
Ruma G Singh,Ngoc Nhu Nguyen,Aya Cervantes et al.
Ruma G Singh et al.
Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorde...
Clinical Trial
Peptides. 2019 Sep:119:170117. DOI:10.1016/j.peptides.2019.170117 2019
Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK signaling pathway after weight loss in obese Sprague-Dawley rats [0.03%]
肥胖大鼠体重减轻后下丘脑nesfatin-1通过MC3/4R-ERK信号通路介导摄食行为
Tianyi Zhang,Mofei Wang,Lei Liu et al.
Tianyi Zhang et al.
Nesfatin-1 is an anorexic peptide derived from nucleobindin 2 (NUCB2). An increase in hypothalamic nesfatin-1 inhibits feeding behavior and promotes weight loss. However, the effects of weight loss on hypothalamic nesfatin-1 levels are uncl...
Protective effect of PACAP-38 on retinal pigmented epithelium in an in vitro and in vivo model of diabetic retinopathy through EGFR-dependent mechanism [0.03%]
PACAP-38通过EGFR依赖性机制在糖尿病视网膜病变的体外和体内模型中对色素上皮细胞的保护作用
Grazia Maugeri,Agata Grazia D&#x;Amico,Claudio Bucolo et al.
Grazia Maugeri et al.
Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. In the last years, several in vivo studies have demonstrated the protective role of pituitary adenylate cyclase-activating peptide (PACAP-38) to co...
Natural ACE inhibitory peptides discovery from Spirulina (Arthrospira platensis) strain C1 [0.03%]
螺旋藻品系C1中天然血管紧张素转换酶抑制肽的发掘
Krittima Anekthanakul,Jittisak Senachak,Apiradee Hongsthong et al.
Krittima Anekthanakul et al.
Bioactive peptides from natural sources are utilized as food supplements for disease prevention and are increasingly becoming targets for drug discovery due to their specificity, efficacy and the absence of undesirable side effects, among o...
Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide [0.03%]
BMAP-27的作用机制及结构分析一种由 катhekisin衍生的抗菌肽
Sungtae Yang,Chul Won Lee,Hak Jun Kim et al.
Sungtae Yang et al.
BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains...
The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats [0.03%]
胆汁分流术后大鼠肠内内分泌细胞的前激素表达谱式
Chen Zhang,Kristoffer Rigbolt,Søren Ljungberg Petersen et al.
Chen Zhang et al.
Objective: Roux-en-Y gastric bypass (RYGB) leads to rapid remission of type 2 diabetes (T2D) and sustained body weight loss, but the underlying molecular mechanisms are still not fully understood. To further elucidate the...
Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus [0.03%]
超氧阴离子介导血管紧张素(1-7)类似物alamandine的对血压和视前区核交感神经活动的影响作用
Juexiao Gong,Yihui Shen,Peng Li et al.
Juexiao Gong et al.
Microinjection of alamandine into the hypothalamic paraventricular nucleus (PVN) increased blood pressure and enhanced sympathetic activity. The aim of this study was to determine if superoxide anions modulate alamandine's effects in the PV...
Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5 [0.03%]
阿皮林-13对阿尔茨海默病大鼠模型的抗焦虑影响：涉及糖皮质激素受体和FKBP5的作用
Samaneh Aminyavari,Maryam Zahmatkesh,Fariba Khodagholi et al.
Samaneh Aminyavari et al.
Apelin-13 is known to be one of the predominant neuropeptides with marked protective role in circuits involved in mood disturbances. The most putative hypothesis in pathophysiology of Alzheimer's disease (AD) is Amyloid beta (Aβ) aggregati...
Plasma orexin-A-like immunoreactivity levels and renal function in patients in a geriatric ward [0.03%]
老年病房患者血浆纤皮素A样免疫反应性及肾功能水平分布及其相互关系
Hirotaka Nakashima,Hiroyuki Umegaki,Madoka Yanagawa et al.
Hirotaka Nakashima et al.
Orexin-A is a neuropeptide mainly produced by hypothalamic neurons with functions in the central nervous system such as regulation of the sleep-wake cycle. Recent studies suggest that orexin-A also plays major roles in peripheral tissues. A...
Effects of islet neogenesis associated protein depend on vascular endothelial growth factor gene expression modulated by hypoxia-inducible factor 1-alpha [0.03%]
缺氧诱导因子1-α调节的血管内皮生长因子基因表达决定胰岛新生相关蛋白的作用
C L Román,B Maiztegui,M V Mencucci et al.
C L Román et al.
Background: Pharmacology has provided efficient tools to improve insulin effect/secretion but the decrease in β-cell mass remains elusive. INGAP-PP could provide a therapeutic alternative to meet that challenge. ...