Structural determination, distribution, and physiological actions of ghrelin in the guinea pig [0.03%]
结构决定、分布及胡须猪胃促生长素的生理作用
Yuji Okuhara,Hiroyuki Kaiya,Hiroki Teraoka et al.
Yuji Okuhara et al.
We identified guinea pig ghrelin (gp-ghrelin), and examined its distribution and physiological actions in the guinea-pig. Gp-ghrelin is a 28-amino acid peptide (GASFR SPEHH SAQQR KESRK LPAKI QPR); seven amino acids are different from that o...
A new tridecapeptide with an octaarginine vector has analgesic therapeutic potential and prevents morphine-induced tolerance [0.03%]
一种新的三肽通过八精氨酸载体发挥作用具有治疗潜力可预防吗啡耐受性
Vladimir A Kashkin,Elena V Shekunova,Michail I Titov et al.
Vladimir A Kashkin et al.
A growing body of evidence suggests that peptides may possess analgesic effects without tolerance development. The synthetic tetrapeptide Tyr-d-Arg-Phe-Gly-NH2 was modified with the inclusion of a (d-Arg)8 vector to prevent the action of en...
Invasive fungi-derived defensins kill drug-resistant bacterial pathogens [0.03%]
抗药性细菌病原体的杀灭剂：侵入性真菌源的防御素
Jiajia Wu,Shijie Liu,Hao Wang
Jiajia Wu
Fungi-derived defensins are a class of antimicrobial peptides with therapeutic potential due to their high antibacterial efficacy and low toxicity. Based on the genomic strategy, we have identified 68 fungal defensin-like peptides (fDLPs) i...
Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor [0.03%]
斑马鱼GIP在哺乳动物系统中的胰岛素分泌和降低血糖作用的评估：GLP-1受体参与的证据
Galyna V Graham,J Michael Conlon,Yasser H Abdel-Wahab et al.
Galyna V Graham et al.
The insulinotropic properties of zebrafish GIP (zfGIP) were assessed in vitro using clonal pancreatic β-cell lines and isolated mouse islets and acute effects on glucose tolerance and insulin release in vivo were evaluated in mice. The pep...
Expression and functional characterization of tachykinin-related peptides in the blood-feeding bug, Rhodnius prolixus [0.03%]
若尼氏长喙虫Rhodnius prolixus中速激肽相关肽的表达及其功能表征
A N S Haddad,M S Defferrari,S Hana et al.
A N S Haddad et al.
Tachykinins (tachykinin-related peptides, TRPs) are multifunctional neuropeptides that have widespread distribution in the central nervous system (CNS) and in the gastrointestinal tract of many insects, and most have been shown to stimulate...
Grazia Maugeri,Antonio Longo,Agata Grazia D&#x;Amico et al.
Grazia Maugeri et al.
Cornea's posterior surface includes endothelium maintaining stromal hydration and clarity. Due to their limited proliferative capability, the loss of endothelial cells can outcome in permanent opacity. In the last years, different studies h...
Osteoanabolic activity of whey-derived anti-oxidative (MHIRL and YVEEL) and angiotensin-converting enzyme inhibitory (YLLF, ALPMHIR, IPA and WLAHK) bioactive peptides [0.03%]
从乳清中分离出的具有抗氧化作用(MHIRL和YVEEL)和血管紧张素转换酶抑制作用(YLLF，ALPMHIR，IPA和WLAHK)生物活性肽的成骨细胞增殖作用
Masum Pandey,Rajeev Kapila,Suman Kapila
Masum Pandey
Exploring bone rebuilding anabolic agents has been gaining much attention due to their potential therapeutic effects in treating several bone disorders including osteoporosis. Whey protein has been reported to affect bone health osteoanabol...
Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance [0.03%]
胃泌素通过调节活化素A- follistatin失衡抑制心肌梗死心力衰竭大鼠心脏纤维化
Chunyan Yang,Jinsha Liu,Kai Liu et al.
Chunyan Yang et al.
Ghrelin, a growth hormone-releasing peptide, potentially improves cardiac function, but the mechanisms remain unclear. In the study, the rat heart failure (HF) model was established by ligating the left anterior descending coronary artery (...
The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris [0.03%]
CEN1HC-Br的抗痤疮丙酸杆菌作用及其对寻常型痤疮治疗和抗炎作用研究
Rui Han,Hans-Matti Blencke,Hao Cheng et al.
Rui Han et al.
Propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. An antimicrobial peptide named CEN1HC-Br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum ant...
Sub-cellular organization of the melanin-concentrating hormone neurons in the hypothalamus [0.03%]
黑素浓集激素在下丘脑内的亚细胞分布结构
Veronika Jancsik,Roland Bene,Péter Sótonyi et al.
Veronika Jancsik et al.
Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH ...