Long-acting amylin-related peptides as therapies for obesity and type 2 diabetes [0.03%]
长效胰岛素肽类似物治疗肥胖和2型糖尿病的研究进展
Clifford J Bailey,Peter R Flatt,J Michael Conlon
Clifford J Bailey
The first therapeutically useful amylin receptor (AMYR) agonist, pramlintide was based upon the structure of non-aggregating rat amylin and found limited application as an adjunct to insulin therapy. It acts centrally to induce satiety, pro...
EPI-X4 is a peptide antagonist of CXCR4 with therapeutic prospects for cancer and inflammatory disorders [0.03%]
EPI-X4是一种CXCR4肽拮抗剂，在癌症和炎症疾病方面具有治疗前景
Micah N Sagini,Martin R Berger,Jürgen Muthmann et al.
Micah N Sagini et al.
In a deregulated state, the CXCR4/CXCL12 signaling pathway plays a significant role in the development of cancer and inflammatory disorders. Currently, plerixafor (AMD3100) is the only approved CXCR4 antagonist used to mobilize hematopoieti...
Ghrelin attenuates skeletal-muscle atrophy by regulating muscle protein degradation and lung inflammation in aged male mice with lipopolysaccharide-induced lung injury [0.03%]
胃饥饿素通过调节肌肉蛋白质降解和脂多糖诱导的肺损伤老年小鼠的肺部炎症来减轻骨骼肌萎缩
Moeka Honda,Hironobu Tsubouchi,Rika Inomata et al.
Moeka Honda et al.
Sarcopenia is a progressive and generalized skeletal muscle disorder characterized by reduced muscle mass and strength, leading to adverse outcomes such as frailty and increased mortality. Pneumonia can accelerate the progression of sarcope...
Genetic deletion of neuromedin U and neuromedin S confers transient reno-protection in adenine-induced chronic kidney disease [0.03%]
基因敲除神经肽素U和神经肽素S可对腺嘌呤致慢性肾脏病产生短暂的保护作用
Hiroshi Yoshida,Hitoshi Teranishi,Kenshiro Shikano et al.
Hiroshi Yoshida et al.
Neuromedin U (NMU) and neuromedin S (NMS) are neuropeptides that regulate metabolic, inflammatory, and fibrotic responses through shared receptors. Although dysregulated NMU/NMS signaling has been implicated in metabolic and inflammatory di...
Yoichi Ueta,Tatsushi Onaka
Yoichi Ueta
Human β-defensin-3 as a transcriptional convergence point linking innate immunity, endocrine signals, and tissue repair [0.03%]
人类β-防御素-3作为固有免疫、内分泌信号和组织修复的转录汇聚点
Yolanda M Jacobo-Delgado,Jaime Eduardo Huerta-Elías,Valeria Cabral-Venegas et al.
Yolanda M Jacobo-Delgado et al.
Human β-defensin 3 (hBD-3) is a multifunctional host defense peptide with exceptional antimicrobial, immunomodulatory, and tissue-repair properties. Beyond its potent activity against gram-positive and gram-negative bacteria, fungi, and se...
The Protective Role of Nesfatin-1 Against TNF-α-Induced Ferroptosis in Chondrocytes: Implications for Osteoarthritis Therapy [0.03%]
Nesfatin-1通过抑制TNF-α诱导的软骨细胞铁死亡对骨关节炎发挥保护作用
Yue Wang,Kaili Hu,Fenglin Jiang et al.
Yue Wang et al.
Osteoarthritis (OA) progression is significantly driven by chondrocyte ferroptosis, a form of iron-dependent cell death triggered by oxidative stress and lipid peroxidation. This study investigated the protective effect of Nesfatin-1 agains...
Apelin-36 Attenuates Diabetic Glomerular Endothelial Hyperpermeability via the KLF2/Occludin Pathway [0.03%]
阿皮林通过KLF2/Occludin通路缓解糖尿病肾小球内皮高渗透性
Jinxiao Jiang,Liu Yang,Yuhao Cheng et al.
Jinxiao Jiang et al.
An increase in glomerular endothelial cell (GEC) permeability is an early trigger for diabetic nephropathy (DN). This study investigated the protective role of the Apelin-36/APJ axis under diabetic conditions. In vitro, high glucose (HG) do...
A pioneer at the interface: Annette Beck-Sickinger - The 2026 Victor Mutt Award Awardee [0.03%]
界面领域的先驱者：安妮特·贝克-西金格——2026年度维克托·穆特奖获奖人
Herbert H Herzog,William F Colmers
Herbert H Herzog
The roles of nesfatin-1 in the lateral parabrachial nucleus on feeding and glucose metabolism in type 1 diabetic rats [0.03%]
nesfatin-1在1型糖尿病大鼠延髓外侧旁核对摄食和糖代谢的作用机制研究
Caishun Zhang,Qing Zhang,Liuxin Wang et al.
Caishun Zhang et al.
Nesfatin-1 assumes a crucial role in the regulation of appetite and glucose metabolism. The present study aimed to determine the effect of LPBN nesfatin-1 on food intake and blood glucose in type 1 diabetes (T1DM) rats and underlying mechan...