Association between cognitive adverse effects of anticholinergic medication and development of dementia in Parkinson's disease [0.03%]
抗胆碱能药物的认知不良反应与帕金森病患者痴呆发展的关系
Su Hyeon Ha,Seoyeon Kim,Seungmin Lee et al.
Su Hyeon Ha et al.
Introduction: Approximately one-third of patients with Parkinson's disease (PD) develop dementia, and anticholinergic use has been implicated as a risk factor, particularly with prolonged exposure. This study examined whe...
Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of G2019S LRRK2-Associated Parkinson's disease [0.03%]
保护作用还是致病作用？G2019S-LRRK2相关帕金森病的蛋白激酶活性及其神经发育起源
Emilia M Gatto,Alberto J Espay,Melisa Espindola et al.
Emilia M Gatto et al.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common monogenic cause of Parkinson's disease (PD), with the p.Gly2019Ser (G2019S) variant being particularly prevalent. The LRRK2 gene encodes a large, multi-domain pr...
Impact of best practice advisory on reducing contraindicated medications in hospitalized patients with Parkinson's disease [0.03%]
最佳实践建议对住院帕金森病患者减少禁忌药物的影响
Zhimin Xu,Andy Jiang,Nishitha Bujala et al.
Zhimin Xu et al.
Background: Patients with Parkinson's disease (PD) face heightened risks during hospitalization, including prolonged hospital stay and discharge to higher levels of care. Possible contributing factors include non-adherenc...
High fear-of-falling in Parkinson's disease: Distinct clinical phenotypes with motor and non-motor dominance [0.03%]
帕金森病高跌倒恐惧症：以运动和非运动症状为主的临床亚型
Halil Onder,Dilek Iscan,Helin Tunc et al.
Halil Onder et al.
Background: Fear-of-falling (FOF) in Parkinson's disease (PD) reflects both motor and non-motor determinants and is associated with reduced quality of life (QoL). However, its dominant clinical drivers in highly concerned...
Phenotypic spectrum, etiology and outcomes of infection-related movement disorders: An observational cohort study [0.03%]
感染相关运动障碍的表型范围、病因及结局：一项观察性队列研究
Divyani Garg,Archita Makharia,Ayush Agarwal et al.
Divyani Garg et al.
Background: Infection-related movement disorders (IRMD) constitute nearly one-fifth of secondary movement disorders, with higher prevalence in endemic regions. Timely recognition is critical, as many are treatable or prev...
Phenotypic heterogeneity in P102L Gerstmann-Sträussler-Scheinker disease: A case of spastic paraparesis with ataxia [0.03%]
P102L致病型Gerstmann-Sträussler-Scheinker病的临床异质性：痉挛性截瘫伴共济失调一例报告
Karla Salinas-Barboza,Juan Manuel Altamirano
Karla Salinas-Barboza
Effects of Transcranial Pulse Stimulation (TPS) as a potential "add-on" intervention in patients with Parkinson's disease [0.03%]
经颅脉冲刺激(TPS)作为可能的帕金森病“附加”干预手段的效果研究
Paolo Manganotti,Marco Liccari,Tiziana Maria Isabella Lombardo et al.
Paolo Manganotti et al.
Two homozygous KIF1C variants in a Turkish family presenting with cerebellar dysfunction and spastic paraparesis with MRI findings [0.03%]
两个纯合KIF1C变异导致的土耳其一家系小脑功能障碍和痉挛性截瘫的MRI研究
Gullu Tarhan,Sahinde Fazilet Hiz,Busra Elif Inanir et al.
Gullu Tarhan et al.
Lubna Jafri,Jessica Tate,Mary Ann Thenganatt et al.
Lubna Jafri et al.
Introduction: Clinical success of deep brain stimulation (DBS) depends on accurate electrode placement and stimulation within the brain targets. This study aims to explore the optimal stimulation site in the globus pallid...
Retinal structural changes in Parkinson's disease: differences in pRNFL thickness between GBA1-associated and idiopathic cases [0.03%]
GBA1突变和原发性帕金森病患者视网膜结构改变的差异
Giacomo Portaro,Michelangelo Giacomelli,Sara Grisanti et al.
Giacomo Portaro et al.
Introduction: In recent years, retinal structural changes have attracted considerable attention as a potential biomarker of neurodegeneration in Parkinson's disease (PD). Several studies have reported a reduced Retinal Ne...