Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia [0.03%]
基于血浆小细胞外囊泡的转录组分析鉴定出潜在的帕金森病痴呆诊断生物标志物
Anto P Rajkumar,Abdul Hye,Sue Fen Tan et al.
Anto P Rajkumar et al.
Introduction: Blood-based biomarkers that can aid diagnosis of Parkinson's Disease (PD) dementia (PDD), and predict PDD onset in people with PD are urgently needed. Plasma small extracellular vesicles (SEV) reflect molecu...
Zachary Schneider,Hui Liu,Mohammad Dehestani et al.
Zachary Schneider et al.
Rare damaging variants in the SLC25A46 gene were recently reported to be associated with optic atrophy and parkinsonism in compound heterozygous state. Here, we comprehensively investigated the role of SLC25A46 variation in idiopathic Parki...
Sleep disordered breathing in Parkinson's disease: Assessing the relevance of REM behavior sleep disorder and hypoxic burden [0.03%]
帕金森病睡眠呼吸障碍的研究：评估快速动眼期睡眠行为障碍和低氧负荷的相关性
Paulo Bugalho,Vítor Mendes Ferreira
Paulo Bugalho
Introduction: The effects of sleep disordered breathing (SDB) in Parkinson's Disease (PD) are poorly understood. Data is uncertain regarding correlation with REM sleep behavior disorder (RBD) and the effects on non-motor ...
Cardiac autonomic dysfunction in patients with multiple system atrophy and spinocerebellar ataxia: A comparative study and distinctive machine learning model [0.03%]
多系统萎缩和脊髓小脑性共济失调患者的心血管自主神经功能障碍：一项比较研究及机器学习模型的建立
Praewchompoo Sathirapanya,Natlada Limotai,Narupat Suanprasert et al.
Praewchompoo Sathirapanya et al.
Background: Differentiating multiple system atrophy-cerebellar subtype (MSA-C) from spinocerebellar ataxia (SCA) is often difficult due to overlapping cerebellar and autonomic manifestations. Heart rate variability (HRV) ...
Beifang Yuan,Jiayu Han,Yan Li et al.
Beifang Yuan et al.
Atypical parkinsonism with dystonia and bulbar dysfunction with a ATP1A3 gene disease-causing variant [0.03%]
携带ATP1A3基因致病突变的以肌张力障碍和球部功能障碍为主的非典型帕金森综合征病例报告
Rita Nunes Rato,André Fernandes,Daniela Ferro et al.
Rita Nunes Rato et al.
Longitudinal brain morphometry in Parkinson's disease clinical subtypes: Distinct signatures forecast behavioral change within subtypes [0.03%]
帕金森病临床亚型的纵向脑形态学特征：不同标志预示着亚型内的行为变化
Abdulmunaim M Eid,Sarah Grossen,Aaron Tanenbaum et al.
Abdulmunaim M Eid et al.
Background: Parkinson's disease (PD) is clinically heterogenous. We previously identified a multi-domain classification of distinct PD subtypes in participants without dementia, yielding Motor Only, Psychiatric & Motor, a...
Expanding the genotypic and phenotypic spectrum of DYT-TSPOAP1: First report from India [0.03%]
DTY-TSPOAP1的基因型和表型谱系扩展：来自印度的首例报道
Vikram V Holla,Debjyoti Dhar,Riyanka Kumari et al.
Vikram V Holla et al.
Pathogenic variants in TSPOAP1, encoding RIMBP1, cause ultra-rare autosomal recessive dystonia (DYT-TSPOAP1/DYT-22), with only two reports worldwide. Clinical features include upper-segment-predominant dystonia, intellectual disability, eye...
Reducing caregiver burden in advanced Parkinson's disease through targeted training: A longitudinal study with dose-response modeling [0.03%]
针对培训通过靶向训练减少帕金森病晚期照护者的负担：具有剂量反应建模的纵向研究
Yunli Ge,Qiya Tong,Xiaolin Song et al.
Yunli Ge et al.
Background: Family caregivers of people with advanced Parkinson's disease (PD) experience substantial psychological, physical, and economic strain. The optimal intensity ("dose") of structured caregiver training to lessen...