Developmental embedding of parvalbumin-positive interneurons drives local and crosshemispheric prefrontal gamma synchrony [0.03%]
发育嵌入的钙结合蛋白阳性中间神经元驱动前额叶局部和半球间伽马同步化
Anton Offermanns,Jastyn A Pöpplau,Ileana L Hanganu-Opatz
Anton Offermanns
Gamma oscillations are critical for cortical cognitive processing. The ability to generate gamma oscillations evolves with age and requires cellular adjustments of the underlying neural networks. In the prefrontal cortex, gamma oscillations...
Altered somatostatin receptor 3 expression and functional dysregulation in tuberous sclerosis complex [0.03%]
结节性硬化症小鼠纹状体中生长抑素受体3的表达和功能失调发生改变
Mirte Scheper,Alessandro Gaeta,Gabriele Ruffolo et al.
Mirte Scheper et al.
Somatostatin (SST), a neuropeptide primarily synthesized by GABAergic interneurons, modulates neuronal excitability and synaptic transmission through its interaction with somatostatin receptors (SSTRs). Dysregulation of SST signaling has be...
Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing [0.03%]
不同神经退行性疾病的皮层神经生理学与健康老化之间的差异性分析研究
Michael Trubshaw,Oliver Kohl,Chetan Gohil et al.
Michael Trubshaw et al.
Neurodegenerative diseases involve disruption of healthy brain network communication occurring before the emergence of symptoms. Magnetoencephalography (MEG) is sensitive to the magnetic fields generated by cortical neuronal activity, and t...
Respiratory coordination of excitability states across the human wake-sleep cycle [0.03%]
人觉醒-睡眠周期中呼吸协调兴奋性状态的变化
Andrea Sánchez Corzo,Esteban Bullón Tarrasó,Martina Saltafossi et al.
Andrea Sánchez Corzo et al.
While the respiratory rhythm is increasingly recognized as a key modulator of oscillatory brain activity across the wake-sleep cycle in humans, very little is known about its influence on aperiodic brain activity during sleep. This broadban...
Glycine and glycine transport control dendritic excitability and spiking [0.03%]
甘氨酸和甘氨酸转运控制树突兴奋性和尖峰发放
Kirsten Bohmbach,Vincent Bauer,Christian Henneberger
Kirsten Bohmbach
Neuronal dendrites integrate excitatory input. They can perform local computations such as coincidence detection by amplifying synchronized local input and dendritic spiking. Extracellular glycine could be a powerful modulator of such proce...
The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases [0.03%]
溶酶体与蛋白质稳态压力在儿科神经疾病和成人神经系统退行性疾病之间的关联
Courtney Lane-Donovan,Mercedes Paredes,Aimee W Kao
Courtney Lane-Donovan
In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygous, result in adult-onset neurodegenerative disease. A shared feature linking these genes? ...
The neurobiology of major depressive disorder: Updates and perspectives from proteomics [0.03%]
抑郁症的神经生物学：来自蛋白质组学的更新和观点
Vittoria Spero,Sabrina D&#x;Amelio,Sonia Eligini et al.
Vittoria Spero et al.
Major depressive disorder (MDD) is a widespread and disabling condition whose etiology and pathophysiology are not fully understood. Furthermore, pharmacological treatment of MDD poses challenging aspects, including delayed therapeutic effe...
Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats [0.03%]
催产素受体配体对慢性社会挫败应激大鼠焦虑状行为、社交回避及眶额皮层内催产素受体表达变化的影响
Lucas Canto-de-Souza,Daniela Baptista-de-Souza,Cristiane Busnardo et al.
Lucas Canto-de-Souza et al.
We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chroni...
Inhibiting the JAK-STAT3 pathway in nucleus accumbens astrocytes alleviates cocaine-induced motor hyperactivity [0.03%]
抑制伏隔核星形胶质细胞中的JAK-STAT3途径可缓解可卡因引起的运动过度活跃症状
Isabelle Arnoux,Anna Capano,Rachida Yakoubi et al.
Isabelle Arnoux et al.
Cocaine use disorder is a significant global health issue, and despite its widespread impact, effective treatments are lacking. While research has largely focused on the underlying neuronal mechanisms, the role of astrocytes, key regulators...
D1-type dopamine receptors are critical for GABAergic synaptic plasticity in CA1 mouse hippocampal SST interneurons and pyramidal cells [0.03%]
D1型多巴胺受体对CA1鼠海马SST中间神经元和锥体细胞GABA能突触可塑性至关重要
Patrycja Brzdąk,Katarzyna Lebida,Patrycja Droździel et al.
Patrycja Brzdąk et al.
Dopamine modulates brain functions such as memory and learning, and studies into underlying mechanisms have been largely focused on glutamatergic synapses and their plasticity. Much less is known about the dopaminergic modulation of inhibit...