Summbla Anjum,Maria J Sosa,Andrea Serino et al.
Summbla Anjum et al.
Our brains support at least two major spatial representations: an egocentric, short-horizon representation of peripersonal space (PPS), and an allocentric, longer-horizon cognitive map system. Here, we speculate on their relationship from a...
Félix Leroy,Pablo Gimenez,Quirin Krabichler et al.
Félix Leroy et al.
Neuropeptides are evolutionarily ancient signaling molecules that predate neurons and the central nervous system, yet they now function as powerful regulators of physiology and complex behavior. This review proposes that their success deriv...
Beyond the brake: The subthalamic nucleus predominantly facilitates action in non-human primates [0.03%]
Atsushi Yoshida,Richard J Krauzlis,Okihide Hikosaka
Atsushi Yoshida
The subthalamic nucleus (STN) is a core component of the basal ganglia circuitry, traditionally viewed as a "brake" that suppresses motor output via the indirect and hyperdirect pathways. While this model explains certain aspects of motor c...
Pattern separation memory requires Cerebellin 4 - Neogenin 1 signaling at dentate gyrus synapses [0.03%]
模式分离记忆需要小脑蛋白4-新生蛋白1在齿状回突触信号转导
Kif Liakath-Ali,Dong Il Choi,Xiao Han et al.
Kif Liakath-Ali et al.
The ability to avoid confusion between similar episodic memories enables organismal survival and fitness. This evolutionarily conserved differentiation process of memories as distinct representations is known as pattern separation. A centra...
Marco Micali,Nicola Toschi,Allegra Conti
Marco Micali
Demyelinating diseases, such as multiple sclerosis, result from the progressive loss of myelin sheaths in the central and peripheral nervous systems, leading to impaired neural conduction and disability. Current disease-modifying therapies ...
Maresin1 mitigates morphine analgesic tolerance via the Lgr6 pathway [0.03%]
maresin1通过Lgr6途径缓解吗啡镇痛耐受性
Xinyi Tian,Jishi Ye,Chenxi Shen et al.
Xinyi Tian et al.
Repeated morphine administration leads to analgesic tolerance, reducing its pain-relief effectiveness and increasing overdose risks. However, the changes in endogenous levels of specialized pro-resolving mediators and their relationship wit...
Glial dynamics in brain aging: Cellular heterogeneity and regional vulnerability [0.03%]
脑衰老中的胶质动力学：细胞异质性和区域脆弱性
Kyoungho Suk
Kyoungho Suk
Brain aging involves progressive structural, functional, and molecular changes that impair cognition and increase vulnerability to neurodegenerative diseases. While neurons have traditionally received primary research focus, recent advances...
Epm2bP71A and Epm2bD148N knock-in mouse models of Lafora disease exhibit distinct and pronounced neurological alterations [0.03%]
Epm2bP71A和Epm2bD148N敲入小鼠模型中的Lafor病表现出不同而显著的神经学变化
Nerea Iglesias-Cabeza,Luis Zafra-Puerta,Carolyn A Worby et al.
Nerea Iglesias-Cabeza et al.
Lafora disease is a rare, autosomal recessive neurodegenerative disorder characterized by the progressive accumulation of abnormal, insoluble, and hyperphosphorylated forms of glycogen, known as Lafora bodies, in the brain and other tissues...
Microglial P2Y12 signaling phase-shifts glymphatic circadian rhythms and alters sleep architecture in mice [0.03%]
小胶质细胞P2Y12信号使淋巴脑脊液循环节律相位偏移并改变小鼠睡眠结构
Lihan Su,Miaomiao Tian,Ya Hao et al.
Lihan Su et al.
Microglia regulate neural circuits and vascular-glial interfaces, yet whether microglial purinergic signaling coordinates glymphatic function and brain state remains unclear. We tested the role of the microglial Gi-coupled receptor P2Y12 us...
HTRA1 and brain disorders: A balancing act across neurodegeneration and repair [0.03%]
HTRA1与大脑疾病：神经退行性疾病与修复之间的平衡作用
Simone Hjæresen,Emilie Trommer Gramkow,Mengliang Zhang et al.
Simone Hjæresen et al.
High temperature requirement protein A1 (HTRA1) is a trypsin-like serine protease increasingly recognized as a central regulator of brain homeostasis. HTRA1 is broadly expressed in the brain, where it regulates proteostasis, extracellular m...