Gut microbiota perturbation and systemic inflammation are associated with salcaprozate sodium (SNAC)-enabled oral semaglutide delivery [0.03%]
肠道微生物紊乱和全身性炎症与索卡普罗扎钠（SNAC）促进的口服司美格鲁肽吸收有关
Amin Ariaee,Karim Noueihad,Alex Hunter et al.
Amin Ariaee et al.
Semaglutide (SEM) is a glucagon-like peptide-1 (GLP-1) receptor agonist formulated for oral delivery with the absorption enhancer salcaprozate sodium (SNAC). Although oral SEM achieves 0.4-1% bioavailability through gastric epithelial uptak...
Engineered cargo-free nanoparticle decoys for phagocytic modulation of macrophages [0.03%]
用于巨噬细胞吞噬调节的工程化无载药纳米颗粒诱饵
Peyton M Panovich,Aditi Ganesan,Arianna I Markey et al.
Peyton M Panovich et al.
Polymeric nanoparticles (NPs) are a versatile delivery platform for non-viral genetic therapies. However, a key shortcoming of polymeric NPs (and other non-viral delivery vehicles) is the often-high accumulation of NPs within the liver and ...
Injectable acid-labile thermosensitive magnetic hydrogel with responsive drug release for bridging liver transplantation in hepatocellular carcinoma [0.03%]
一种可注射的酸不稳定的热敏磁性水凝胶，具有响应性的药物释放功能，可用于肝癌肝移植手术中的血管重建
Huai Yang,Jing-Long Hu,Yunjun Xu et al.
Huai Yang et al.
Percutaneous locoregional drug injection based on hydrogel therapy under image guidance is performed to limit the progression of hepatocellular carcinoma (HCC) and extend the waiting time for liver transplantation patients. However, achievi...
Single intravitreal injection of lipid nanoparticles delivering circular mRNA of nicotinamide phosphoribosyltransferase protects against dry AMD [0.03%]
单剂量玻璃体内注射递送烟酸磷酸核糖转移酶圆环mRNA的脂质纳米颗粒可防治干燥型年龄相关性黄斑变性
Hui-Lin Li,Yu Xu,Jian-Shan Mo et al.
Hui-Lin Li et al.
Age-related nicotinamide adenine dinucleotide (NAD+) deficiency is implicated in numerous pathologies, including dry age-related macular degeneration (AMD). Current NAD+-boosting strategies, reliant on precursors like nicotinamide mononucle...
A comprehensive review on the storage stability of extracellular vesicles for clinical translation: Current status, challenges, and prospects [0.03%]
外泌体储存稳定性的全面综述：现状、挑战和前景
Hai Huang,Wenjie Xu,Xinyan Hao et al.
Hai Huang et al.
Extracellular vesicles (EVs) are now seen as powerful tools for next-generation diagnostics, targeted drug delivery, and cell-free therapies. Their clinical application, however, is constrained by storage challenges-the preservation process...
Lipid nanoparticles containing zwitterionic lipids versatilely enhance the efficiency of mRNA delivery [0.03%]
含两性离子脂质的脂质纳米颗粒可增强信使RNA递送的效率
Yuichi Suzuki,Yuma Yamada,Hideyoshi Harashima et al.
Yuichi Suzuki et al.
Ionizable lipids enable lipid nanoparticles (LNPs) to deliver nucleic acids, including mRNA, to target cells. However, the efficiency of the endosomal escape of conventional LNPs remains limited to a small percentage. Lipid components that ...
Corrigendum to 'A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells' [Journal of Controlled Release 149(2) (2011) 196-205] [0.03%]
“LDL-衣壳的载多柔比星脂质体逆转肿瘤耐药性的研究”一文中关于人癌细胞的研究的勘误说明
Joanna Kopecka,Ivana Campia,Paolo Olivero et al.
Joanna Kopecka et al.
Injectable hydrogel induces tumor cell extracellular calcification and bone regeneration to disrupt the osteolytic vicious cycle in bone metastasis [0.03%]
可注射水凝胶诱导肿瘤细胞外钙化和骨再生以打断骨转移中的溶骨恶性循环
Minzhao Lin,Shaohui Deng,Simin Liang et al.
Minzhao Lin et al.
Bone metastasis is a significant challenge in the treatment of advanced breast cancer, with current treatments mainly providing symptom relief without addressing the osteolytic cycle driven by tumor cells and osteoclasts, which leads to con...
Engineering red blood cells for antigen-specific immune tolerance and personalized therapy of autoimmune diseases [0.03%]
工程化红细胞用于自身免疫病的抗原特异性免疫耐受和个性化治疗
Yeshuang Yuan,Mengfan Yu,Xingxing Zhu et al.
Yeshuang Yuan et al.
Current therapies for autoimmune diseases largely rely on broad-spectrum immunosuppressants and biologics, which indiscriminately deplete T or B cells. These approaches are largely constrained by systemic immunosuppression and off-target to...
Wound healing under the regulation of mechanically active biomaterials: From mechanism exploration to scar prevention [0.03%]
机械响应性生物材料促进伤口修复和抗瘢痕增生的研究进展
Huiqi Zhang,Dong Luo,Guojun Cai et al.
Huiqi Zhang et al.
Severe cutaneous injury predictably culminates in scar formation, typified by the loss of skin appendages and a consequent impairment of both structural integrity and physiological function. A growing body of evidence now indicates that mec...