Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation [0.03%]
铁氧化纳米颗粒对巨噬细胞极化、肿瘤生长和肿瘤微环境调节的影响
Karolin Roemhild,Yanchen Li,Roman A Barmin et al.
Karolin Roemhild et al.
Macrophages are key regulators of the tumor microenvironment (TME) and attractive targets for nanomedicine therapies. Because intracellular iron can promote pro-inflammatory macrophage polarization, superparamagnetic iron oxide nanoparticle...
Structure-corona-function engineering of micelles enables rapid hepatic bioactivation of clopidogrel for emergency antiplatelet therapy [0.03%]
结构-冠状-功能工程微粒能使氯吡格雷快速肝脏活化以应急抗血小板治疗
Qinying Chen,Dali Chen,Zhihao Liu et al.
Qinying Chen et al.
Rapid platelet inhibition is essential for effective management during emergency percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). However, the oral dosage form of clopidogrel (CLP) commonly used in cl...
Corrigendum to "Programming lipopeptide nanotherapeutics for tandem treatment of postsurgical infection and melanoma recurrence" [Journal of Controlled Release 362 (2023) 565-576] [0.03%]
关于“编程脂肽纳米治疗剂以联合治疗术后感染和黑色素瘤复发”一文的勘误[J. 控释药物系统，2023，卷362，565-576页]
Ding-Yi Zhang,Rui-Ge Cao,Yin-Jia Cheng et al.
Ding-Yi Zhang et al.
Brian Youden,Andrew Carrier,Naizhen Yu et al.
Brian Youden et al.
Reactive oxygen and nitrogen species are essential to several biological functions, from maintaining cellular homeostasis to driving disease progression and aging. As such, the precise modulation of cellular redox states has emerged as a pr...
Microbial medicines: Unlocking the therapeutic potential of the microbiome in cancer treatment [0.03%]
微生物药物：解锁微生物组在癌症治疗中的潜力
Abram Canowitz,Nitin S Kamble,Nathan Muck et al.
Abram Canowitz et al.
Microorganisms have had an established relationship with the maintenance of human health, and recent advancements in genetic engineering and synthetic biology have allowed the development of engineered microbes as targeted disease treatment...
Nilesh Malavia,Diane J Burgess
Nilesh Malavia
Long acting injectable (LAI) suspensions represent a promising drug delivery platform, offering a number of advantages such as sustained therapeutic effects, improved patient adherence, and reduced dosing frequency for the management of chr...
Utilizing biorecognition to prime tumors for enhanced nanomedicine delivery of alpha therapies [0.03%]
利用生物识别技术激活肿瘤以增强纳米药物递送α疗法的效果
Nicholas L Fletcher,Weijing Chu,Pie Huda et al.
Nicholas L Fletcher et al.
Targeted Radionuclide Therapy (TRT) enables selective delivery of radionuclides for cancer treatment. Alpha particle emitters such as 212Pb are emerging as potential gamechangers, representing highly potent payloads for precision therapy an...
Slug-mucus-inspired single-cell coating enhances the treatment of inflammatory bowel disease by improving probiotic colonization efficiency [0.03%]
受鼻涕虫黏液启发的单细胞涂层通过提高益生菌定植效率来增强炎症性肠病的治疗
Jinfan Yang,Jiachen Wang,Ning Shang et al.
Jinfan Yang et al.
Probiotics alleviate symptoms of inflammatory bowel disease (IBD), metabolic disorders, and cardiovascular disorders by modulating the gut microbiota. However, oral probiotics face significant survival challenges due to the protective envir...
Albofungin vesicle nanobombs trigger lysosomal disruption for self-enhanced pyroptosis and cGAS-STING pathway activation in glioblastoma immunotherapy [0.03%]
白青霉素素囊泡纳米炸弹触发溶酶体破裂，增强星形胶质瘤免疫治疗中的细胞焦亡和cGAS-STING途径激活效应
Chen Chen,Shuai Tan,Xiaojing Zhu et al.
Chen Chen et al.
Glioblastoma (GBM) remains one of the most intractable malignancies owing to the dual challenges of the blood brain barrier (BBB) and profound immunosuppression. Here, we present a nanobomb (OMV-ApoE@ALF) that integrates heterologous produc...
Augmenting cuproptosis and anti-metastatic immunity in breast cancer by copper-based nanoplatform for synergistic immunotherapy via lactate metabolic reprogramming and hypoxia alleviation [0.03%]
基于铜的纳米平台通过乳酸代谢重编程和缓解缺氧来增强乳腺癌中杯ropyosis和抗转移免疫以实现协同免疫治疗
Hao Wang,Keru Ma,Zhenhao Li et al.
Hao Wang et al.
Breast cancer remains a leading cause of cancer-related mortality in women, with the clinical efficacy of immune-checkpoint inhibitors limited by low tumor immunogenicity. Intracellular copper accumulation can induce cuproptosis, an immunog...