Nanoceria drive stem cell hepatic differentiation and microenvironment remodeling for acute liver failure therapy [0.03%]
纳米氧化铈促进干细胞向肝细胞分化及微环境重塑治疗急性肝衰竭
Fenfang Li,Guipan Chen,Tiantian Xue et al.
Fenfang Li et al.
Stem cell-derived hepatocyte therapy holds great potential for treating acute liver failure (ALF) by rapidly restoring liver function and stimulating regeneration. However, significant challenges remain in efficiently driving stem cells tow...
Anti-CLEC7A nanobody in situ engineering promotes amyloid-β oligomers clearance by CAR-microglia to alleviate Alzheimer's disease pathology in mice [0.03%]
抗CLEC7A纳米体原位工程通过CAR小胶质细胞促进淀粉样蛋白寡聚体清除以缓解小鼠阿尔茨海默病病理损害
Chongzheng Yan,Zhichao Kong,Yuxue Pan et al.
Chongzheng Yan et al.
Chimeric antigen receptor microglia (CAR-M)-mediated amyloid-β oligomers (AβO) phagocytosis shows great promise in Alzheimer's disease (AD) treatment, however, the limited AβO degradation of CAR-M compromises their anti-AβO potency. Thi...
Compacted solid implant formulations for long-term buprenorphine delivery [0.03%]
用于长期丁丙诺啡递送的压缩固体植入剂型
Andrew Otte,Kinam Park
Andrew Otte
Opioid use disorder (OUD) remains a major public health challenge in the United States, and medication-assisted treatment with buprenorphine, a μ-opioid receptor partial agonist, is a cornerstone of effective management. Currently marketed...
Carrier-free PANoptosis nanoinducers synergize with immunometabolic reprogramming for enhanced immunotherapy [0.03%]
无载体PANoptosis纳米诱导剂与免疫代谢重编程协同增强免疫治疗
Zilin Ma,Songyan Li,Wen Zhao et al.
Zilin Ma et al.
Immunogenic cell death (ICD)-based immunotherapy holds great promise for cancer treatment, but the therapeutic effectiveness of ICD driven by a single death pathway is often limited due to tumor regulatory mechanisms and the immunosuppressi...
Nucleic acid drug delivery in ophthalmology: Emerging trends and future perspectives [0.03%]
眼科核酸药物递送：新兴趋势与未来展望
Hengye Yang,Jiamin Zuo,Songzhang Lv et al.
Hengye Yang et al.
Nucleic acid therapeutics offer the broadest range of target selection and manipulation, making them an ideal choice for ocular targeted therapy. However, the clinical translation of the vast majority of nucleic acid therapeutics relies on ...
Multiplexed spatial screening of lipid-based nanoparticles for extrahepatic messenger RNA targeting [0.03%]
用于外肝靶向的基于脂质的纳米颗粒的空间筛选多功能化技术
Thomas Enzlein,Jens Schumacher,Alexander Geisel et al.
Thomas Enzlein et al.
Lipid-based and other types of nanoparticles (NPs) enable target- and organ-specific, efficient extrahepatic delivery of synthetic messenger RNA (mRNA) or other cargos in vivo. However, clinical translation of targeting mRNA NP products is ...
Lipid droplet-regulated multipathway-induced type I interferon tempest for ferroptosis-immune synergistic therapy of tumors [0.03%]
由脂滴调节的多通路诱导I型干扰素风暴介导的铁死亡-免疫协同抗肿瘤疗法
Bin Ren,Haolong Ma,Zongheng Li et al.
Bin Ren et al.
The upstream signals of stimulator interferon genes (STING) are diverse, and the key of STING-mediated tumor immunotherapy lies in induction of type I interferon (IFN-I) production. Herein, Tacrine (TCR) and SR717 loaded hollow mesoporous m...
Glucose-hijacked nanobots: Enabling deep tumor penetration via a self-enhanced permeability cascade [0.03%]
葡萄糖劫持的纳米机器人：通过自我增强渗透级联实现深达肿瘤内部渗透
Dongdong Wang,Yuxin Wang,Yajuan Xie et al.
Dongdong Wang et al.
The therapeutic efficacy of nanomedicine is critically hampered by poor tumor penetration. While nanomotors offer a promising approach to enhance delivery, their effectiveness is constrained by the limited and heterogeneous distribution of ...
Immunosuppressive-responsive hydrogel for self-regulated drug release and tumor microenvironment reprogramming [0.03%]
自调节药物释放和肿瘤微环境重编程的免疫抑制响应水凝胶
Yuxin Wang,Qinghe Wang,Xiyue Xu et al.
Yuxin Wang et al.
The tumor immunosuppressive microenvironment (TIME) critically suppresses antitumor immunity and fosters tumor growth and metastasis, leading to treatment resistance and poor prognosis. Inhibition of the upstream immunosuppressive regulator...
Yu-Ting Tang,Ning Ding,Hua-Shan Li et al.
Yu-Ting Tang et al.
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, represents a group of chronic, relapsing intestinal disorders of complex pathogenesis and increasing global incidence. Current therapeutic strategies, incl...