Beyond the magic bullet: Programming delivery systems to overcome the antibody specificity paradox [0.03%]
超越魔法子弹：对抗体特异性悖论进行投送系统编程以克服抗体特异性悖论
Yaowei Ma,Yangyihua Zhou,Can Xu et al.
Yaowei Ma et al.
The era of antibody therapeutics, while transformative, has reached a therapeutic plateau. We posit this stagnation stems from a central, unresolved conflict: the Paradox of Specificity, where the exquisite molecular-level targeting of anti...
Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform [0.03%]
一种靶向朗格汉斯细胞的模块化甘露糖基核酸疫苗平台
Simon Christian Vinther,Antonia Resag,Karina Thao Thu Le et al.
Simon Christian Vinther et al.
The skin is a diverse reservoir of immune cells with strong potential for immunotherapeutic delivery. Langerhans cells in the epidermis are antigen-presenting cells, accessible for vaccination using carbohydrate-conjugated therapeutics targ...
Engineering Escherichia coli Nissle 1917 to scavenge lactate enhances anti-tumor immunity [0.03%]
工程改造大肠杆菌Nissle 1917以清除乳酸可增强抗肿瘤免疫反应
Xinrui Li,Yangui Wang,Huilin Xie et al.
Xinrui Li et al.
Bacterial therapy represents a promising approach for cancer treatment, with the probiotic Escherichia coli Nissle 1917 (EcN) being a particularly attractive candidate due to its inherent tumor-targeting capability and established safety pr...
Physiologically controlled release from an in situ forming liposomal depot [0.03%]
生理控制的原位形成脂质体储库中的药物释放
Remo Eugster,Simone Aleandri,Julia Blandine Bassila et al.
Remo Eugster et al.
Poor treatment adherence, often referred to as the "silent epidemic," is a growing global issue that significantly contributes to preventable illness, premature death, and rising healthcare costs. Among compliance-enhancing strategies, cont...
Bone-targeting β-cyclodextrin phosphate has anti-resorptive activity and thereby prevents osteoporosis [0.03%]
靶向骨骼的β-环糊精磷酸具有抗吸收作用并因此可以预防骨质疏松症
Yoshihiro Yoshikawa,Atsushi Tamura,Taishi Higashi et al.
Yoshihiro Yoshikawa et al.
Osteoporosis is a common bone disease that weakens and fragilizes the bones. A wide variety of osteoporosis medicines are available; however, the long-term use of such medicines is not recommended because of major adverse effects. Therefore...
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system attenuates cartilage degeneration in osteoarthritis [0.03%]
靶向表达CXCL16的巨噬细胞仿生纳米载体系统在骨关节炎软骨降解中的治疗作用
Qingjun Yang,Yidi Xu,Yang Zhan et al.
Qingjun Yang et al.
Osteoarthritis (OA) is a whole-joint disorder characterized by progressive cartilage degradation and chronic synovial inflammation, in which macrophages play a central role. Using single-cell RNA sequencing of human and mouse synovial tissu...
A multidomain peptide-liposome composite for controlled release of a cyclic dinucleotide in oral cancer [0.03%]
一种用于口腔癌症中环状二核苷酸控制释放的多域肽-脂质体复合物
Joseph W R Swain,Andrea H Molina,Gemalene M Sunga et al.
Joseph W R Swain et al.
While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combin...
Co-delivery of a STING agonist and indoleamine 2,3-dioxygenase 1 blockade activates type I dendritic cells in cancer [0.03%]
STING激动剂与IDO抑制剂联用可活化I型树突状细胞以治疗癌症
Yanming Xia,Lixin Hu,Yuhan Hu et al.
Yanming Xia et al.
The stimulator of interferon genes (STING) has emerged as a promising target for cancer immunotherapy. However, STING agonists alone have demonstrated limited clinical success. Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated as a k...
Protein corona-guided delivery of dextran-PLGA NPs for enhanced dendritic cell uptake, maturation and improved cancer immunotherapy [0.03%]
蛋白冠引导的葡聚糖-PLGA纳米颗粒递送增强树突状细胞摄取、成熟及改善癌症免疫治疗
An Thi Thanh Vu,Prabhat Shrestha,Thu-Huyen Le Thi et al.
An Thi Thanh Vu et al.
The formation of a protein corona (PC) significantly influences the behavior of nanoparticles (NPs) in biological fluids; however, its impact on immune modulation and therapeutic efficacy has not been completely understood. The dextran coat...
Hybrid hydrogels for biomedical applications: Addressing challenges in drug delivery through advanced crosslinking and nanocarrier integration [0.03%]
用于生物医学应用的混合水凝胶：通过先进的交联和纳米载体整合解决药物输送中的挑战
Muhammad Zahid Anwar,Himanshu Kathuria,Jen Xi Er et al.
Muhammad Zahid Anwar et al.
Recent years have witnessed significant advancements in the engineering potential and biomedical applications of hydrogels, driven by improvements in drug discovery, chemical engineering, and biological sciences. These developments have bro...