Prophylactic sequential drug administration potentiates cancer radiotherapy by inhibiting cholesterol deposition and cellular senescence [0.03%]
预防性序贯给药通过抑制胆固醇沉积和细胞衰老增强癌症放疗效果
Shanshan Lang,Xulu Yang,Xin Zhao et al.
Shanshan Lang et al.
Radiotherapy serves as a mainstream cancer therapy modality, while the adaptive resistance induced by ionizing radiation (IR) hampers the therapeutic efficacy. Among various factors underlying radioresistance, lysosomal cholesterol depositi...
Low-dose radiation generated ROS-activatable doxorubicin prodrug loaded liposome nanoparticles for triple-negative breast cancer treatment [0.03%]
一种低剂量辐射生成的ROS激活型多药耐药纳米脂质体药物前体用于三阴性乳腺癌治疗
Hwanju Lim,Yujeong Moon,Sangheon Han et al.
Hwanju Lim et al.
Triple-negative breast cancer (TNBC) treatment is frequently limited by both intrinsic resistance and normal tissue toxicity in radiation therapy (RT) and chemotherapy. Herein, we report reactive oxygen species (ROS)-activatable DOX prodrug...
Self-assembling freeze-dried vaccine for short HLA-A2-restricted melanoma peptide epitopes [0.03%]
短黑色素瘤HLA-A2限制性肽表位的自组装冻干疫苗
Yuan Luo,Yiting Song,Breandan Quinn et al.
Yuan Luo et al.
Peptide-based cancer vaccines are a promising immunotherapy modality. In this study, a facile lyophilization method was developed to formulate tumor-associated peptide antigens into multiplex vaccines. Lipids, antigens, and adjuvants are di...
Losartan primes pancreatic tumors for effective exosome-biomimetic chemo-immunotherapy [0.03%]
洛萨坦为有效外泌体仿生化疗免疫治疗胰腺肿瘤做准备
Xun Hu,Zihua Wang,Yuting Zhu et al.
Xun Hu et al.
Pancreatic ductal adenocarcinoma (PDAC) is protected by a dense fibrotic stroma that restricts drug delivery and enforces immune exclusion. We describe a clinically actionable, two-stage strategy in which losartan preconditioning transientl...
Liposomal particokinetics and intratumoral microdistribution: A quantitative reassessment of the enhanced permeability and retention effect [0.03%]
脂质体颗粒动力学和瘤内微分布：对增强渗透滞留效应的定量再评估
Yifan Cai,Zichen Zhang,Yi Lu et al.
Yifan Cai et al.
The enhanced permeability and retention (EPR) effect, a cornerstone of cancer nanomedicine, has been predominantly interpreted at the macroscopic level, offering limited insight into the microscopic dynamics governing nanocarrier delivery. ...
Endothelium-inspired coating for hemodialysis needle: Heparin-modulated sustained NO release for synergistic anti-thrombotic and anti-infective effects [0.03%]
受血管内皮启发的透析针涂层：肝素调节的持续一氧化氮释放实现协同抗凝和抗菌效果
Haobo Sun,Hua Qiu,Xiaotong Zhao et al.
Haobo Sun et al.
Thrombosis and infection remain the principal barriers to durable vascular access in hemodialysis, while clinical needles themselves are key drivers of these complications. Inspired by the vascular endothelium, surface modification leveragi...
Ultrasound-guided and activated nanodrugs for highly selective tumor therapy [0.03%]
一种基于超声波引导和激活的纳米药物用于肿瘤的精准治疗
Chuwen Luo,Ya Liu,Weidong Zhao et al.
Chuwen Luo et al.
The selective eradication of cancer cells remains a primary objective in tumor therapy. To this end, tumor-targeted therapy has emerged as a key strategy to enhance drug efficacy and reduce systemic toxicity. Herein, we developed an in situ...
Inducing ferroptosis and reversing immune evasion for the suppression of melanoma lung metastasis via neferine-loaded controlled-release system [0.03%]
荷脑复止咳片抑制肺癌转移的免疫逃避诱导铁死亡逆转作用及机制研究
Dongli Han,Yaqun Li,Zening Liu et al.
Dongli Han et al.
Although melanoma is sensitive to ferroptosis, the upregulation of programmed cell death ligand 1 (PD-L1) induced by ferroptosis contributes to immune evasion. This study demonstrates that Neferine (Nef) effectively inhibits PD-L1 expressio...
Mechanistic understanding of drug release in dissolution apparatuses - In-depth review [0.03%]
药物释放机制的原理理解-综述性文章
Alok Ranjan,Martin Noye Zugah,Raj Kumar Verma et al.
Alok Ranjan et al.
Dissolution apparatuses are indispensable tools in the pharmaceutical industry for evaluating drug release from dosage forms under standardized conditions. They support formulation development, quality control, and regulatory compliance. De...
Self-sacrificing templated-derived chitosan microcapsules for targeted drug delivery in thrombolytic therapy [0.03%]
一种用于溶栓治疗的自牺牲型模板壳聚糖微胶囊及其靶向药物输送方法
Yanling Liang,Weikun Li,Xin Tan et al.
Yanling Liang et al.
Thromboembolic diseases are a major global health threat. Yet current thrombolytic therapies remain limited by systemic off-target effects, short drug half-life, and poor thrombus penetrability. Herein, we report a self-sacrificing template...