Polymyxin B-antioxidant nanoassemblies mitigate nephrotoxicity and attenuate sepsis-induced acute lung injury [0.03%]
抗氧化纳米聚合物可减轻肾毒性并缓解脓毒症诱导的急性肺损伤
Haolin Zhang,Jiang Yu,Rui Zhang et al.
Haolin Zhang et al.
Sepsis is a life-threatening syndrome in which dysregulated host responses drive organ dysfunction; acute lung injury (ALI) is both the most prevalent and the most fatal manifestation. Here we synthesize an ester-linked α-tocopherol-gallic...
Extracellular vesicles from IL-18-overexpressing and/or TGF-β1-deprived tumor cells as an immunogenic antigen source for next-generation DC vaccines [0.03%]
过表达IL-18和/或剥夺TGF-β1的肿瘤细胞来源的胞外囊泡作为下一代树突状细胞疫苗的免疫原性抗原源
Joanna Rossowska,Daria Nawrocka,Bożena Szermer-Olearnik et al.
Joanna Rossowska et al.
Dendritic cell (DC)-based antitumor immunotherapies have demonstrated significant therapeutic potential. Nonetheless, their broader clinical application is limited for several reasons, including the lack of comprehensive sources of tumor an...
Ricardo David Flores-Cruz,Lena Ruiz Azuara,Hélder A Santos
Ricardo David Flores-Cruz
The zebrafish (Danio rerio) has evolved into a strategic, high-throughput platform, bridging the critical gap between in vitro assays and costly mammalian studies in nanomedicine development. This is underscored by its prolific adoption, wi...
Bioorthogonal Cu-MOF nanocatalyst enables GSH-triggered in situ drug synthesis for xCT-driven ferroptosis in colorectal cancer [0.03%]
生物正交Cu-MOF纳米催化剂通过GSH触发的原位药物合成诱导xCT介导的铁死亡用于结直肠癌治疗
Sahil Chahal,Amal Babu,Arathy Vasukutty et al.
Sahil Chahal et al.
Despite advances in colorectal cancer (CRC) therapy, treatment outcomes remain limited by a refractory tumor microenvironment (TME) that restores redox balance and suppresses ferroptotic damage. To address this challenge, we developed HMOI,...
Ling Zou,Xiang You,Jingjing Ma et al.
Ling Zou et al.
Anti-cancer drugs frequently encounter challenges such as inadequate tumor accumulation and limited therapeutic efficacy, leading to recurrence and adverse effects. Advances in drug delivery systems have been instrumental in addressing thes...
An osteoimmunomodulatory microneedle patch targeting ER-mitochondria calcium crosstalk for periodontal tissue regeneration [0.03%]
一种靶向内质网-线粒体钙交叉 talk的骨免疫调节微针贴片用于牙周组织再生
Jinda Li,Qingyue Xiao,Wenjia Cai et al.
Jinda Li et al.
Functional reconstruction of periodontal tissue defects remains a clinical challenge, primarily owing to sustained proinflammatory responses. Endoplasmic reticulum stress (ERS) and mitochondrial dysfunction have been identified as pivotal r...
PtCu-bimetallic modified MOF nanozyme composites for alleviating acute liver injury via reactive oxygen species elimination and inflammation regulation [0.03%]
基于PtCu双金属修饰的MOF纳米酶复合材料通过消除活性氧和调节炎症缓解急性肝损伤
Yu-Ying Cai,Lin-Jiao Yang,Meng-Meng Pan et al.
Yu-Ying Cai et al.
Excessive reactive oxygen species (ROS) accumulation and dysregulated inflammation drive acetaminophen (APAP)-induced acute liver injury (ALI), yet the therapeutic effect of the commonly used clinical drug N-acetylcysteine (NAC) still has c...
Nanoassembly-mediated immunometabolic reprogramming of CD4+ T cells suppresses β-cell autoimmunity in type 1 diabetes [0.03%]
基于纳米组件介导的CD4⁺T细胞免疫代谢重编抑制1型糖尿病β细胞自身免疫反应
Xixi Nan,Shuotong Zhang,Xinyue Chu et al.
Xixi Nan et al.
The pathogenesis of type 1 diabetes mellitus (T1DM), known as autoimmune diabetes, is thought to be mediated by T cell-driven destruction of β cells, with the hyperactivation of CD4+ T cells playing a central role by triggering increased T...
Dual-targeted nano-inhibitors of pyroptosis for synergistic therapy of traumatic brain injury [0.03%]
协同治疗创伤性脑损伤的靶向纳米抑制剂对抗pyroptosis
Zhao Wang,Zhangqiang Ma,Haijuan Fu et al.
Zhao Wang et al.
Secondary neuroinflammation is a major driver of progressive damage after traumatic brain injury (TBI), yet pharmacological interventions are limited by poor drug accumulation in the injured brain. Here, we report tiered-targeting liposomal...
Probiotics with Emodin-nanobackpack restore goblet cell-dependent mucus layer integrity via colonic patches to ameliorate ulcerative colitis [0.03%]
携带番泻叶苷的益生菌通过结肠补丁恢复杯状细胞依赖性粘液层完整性以改善溃疡性结肠炎
Linxin Dai,Qian Wang,Lingling He et al.
Linxin Dai et al.
While mucosal layer restoration is one of the key therapeutic goals for ulcerative colitis (UC), the current clinical treatments, including probiotics and therapeutic agents, fail to achieve it. As mucosal integrity often depends on goblet ...