A systematic approach to develop and characterize a compositionally equivalent buprenorphine in situ forming implant (Sublocade®) [0.03%]
一种用于开发和表征新型缓释丁丙诺啡植入剂（商品名：Sublocade?）的系统方法
Surendra Poudel,Rudra Pangeni,Ziyu Huo et al.
Surendra Poudel et al.
Sublocade® is a PLGA-based in situ forming implant designed for the sustained delivery of buprenorphine, a partial mu-opioid receptor agonist, with a monthly dosing regimen for the treatment of moderate to severe opioid use disorder (OUD)....
Oscillation-generating micromixing (FDmiX) - a new method for manufacturing of mRNA-lipid nanoparticles with scalable high-throughput production [0.03%]
一种用于制造mRNA-脂质纳米颗粒的新型振荡微混合法(FDmiX)及可放大的高通量生产方法
Fitore Mejzini,Frank Erdmann,Julian Kunert et al.
Fitore Mejzini et al.
Microfluidic mixing is a widely used technology for producing lipid nanoparticles (LNPs) that encapsulate messenger RNA (mRNA). One major challenge in advancing LNP-based RNA therapeutics consists of developing formulations that can be manu...
Mechanical stiffness of membrane-anchored backpacks modulates innate immune function in dendritic cells and macrophages [0.03%]
膜锚定背包的机械刚度可调节树突状细胞和巨噬细胞固有免疫功能
He Liu,Zhan Liu,Xuying Hu et al.
He Liu et al.
Phagocytosis-resistant cellular backpacks hold transformative potential for engineering innate immune cells via mechanotransduction. However, the design principles linking the stiffness of the backpacks to innate immune cell function remain...
Intravitreal delivery of LATS1 mRNA by lipid nanoparticles as an effective strategy for uveal melanoma therapy [0.03%]
脂质纳米颗粒递送LATS1信使核糖核酸作为治疗脉络膜黑色素瘤的有效策略
Siyu Dong,Zhaoqi Pan,Miyao Zhu et al.
Siyu Dong et al.
Uveal melanoma (UM) is a rare and highly aggressive intraocular malignancy, in which the key oncogenic driver Yes-associated protein (YAP) is persistently activated due to loss of upstream Hippo kinases, including Large Tumor Suppressor Kin...
An engineered micropatch for oral delivery of heterophyllin B in type 2 diabetes treatment [0.03%]
一种用于2型糖尿病治疗的异叶素B口服微贴片疗法
Yi Chen,Yuanxing Huang,Cheneryu Huang et al.
Yi Chen et al.
Type 2 diabetes mellitus (T2DM) poses a significant global health challenge, highlighting the urgent need for effective therapeutics. Heterophyllin B (HB), a cyclic peptide derived from Pseudostellaria Radix, has been proposed as a promisin...
Genetically engineered Salmonella, SGN1, as a tumor microenvironment-targeting modality capable of methionine reduction for oral squamous cell carcinoma [0.03%]
基因工程沙门氏菌SGN1作为针对肿瘤微环境的药物，可通过降低甲硫氨酸用于治疗口腔鳞状细胞癌
Ping Mao,Xiangqian Wang,Yuerong Peng et al.
Ping Mao et al.
Metabolic reprogramming is a hallmark of cancer, and targeting amino acid metabolism has emerged as a potential promising therapeutic strategy. Herein, we identified through bioinformatic analysis a pronounced methionine metabolic abnormali...
Mapping cellular heterogeneity and dynamic interactions in pancreatic cancer [0.03%]
绘制胰腺癌的细胞异质性和动态相互作用地图
Tatekalva Sandhya,Seema Kumari,Adem Meghapriya et al.
Tatekalva Sandhya et al.
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with a high mortality rate. Intra-tumoral heterogeneity (ITH) increases the severity of PDAC and makes treatment difficult. Insights are provided on ITH to understand the diversit...
Xin Wang Mo,Dong Kwang Min,Jaeyun Kim
Xin Wang Mo
Sepsis is a life-threatening systemic inflammatory response syndrome caused by uncontrolled immune reactions to infection. During its onset, immune cells produce reactive oxygen species (ROS) as critical signaling mediators to activate immu...
A functional lyoprotectant platform enables storage-stable, mucus-penetrating siRNA delivery to the lung [0.03%]
一种功能型冻干保护剂平台实现稳定储存的、能够穿透粘液的siRNA肺部递送
Wenliang Sun,Liangkun Xie,Xiaotong Jiang et al.
Wenliang Sun et al.
Respiratory diseases remain a major global health concern, where pathological mucus accumulation and chronic inflammation severely compromise lung function. RNA therapeutics have emerged as a transformative modality to address underlying mo...
Biodegradable polymersomes encapsulating copper peroxide and gemcitabine for targeted chemoimmunotherapy [0.03%]
负载铜过氧化氢和吉西他滨的可生物降解聚合物囊泡用于靶向化免疫疗
Man Lung Lee,Weiwei Jiang,Jack Chun Hin Chen et al.
Man Lung Lee et al.
Herein, we engineered biodegradable, ROS-responsive polymersomes (HA-PGC) encapsulating gemcitabine (GEM) and copper peroxide nanoparticles (CuO₂), functionalized with hyaluronic acid (HA) to target CD44-overexpressing TNBC cells. Upon rea...