A "three-in-one" thermosensitive gel system that enhances mucus and biofilm penetration for the treatment of vulvovaginal candidiasis [0.03%]
一种“三合一”的热敏凝胶系统，可增强黏液和生物膜穿透力以治疗外阴阴道念珠菌病
Yameng Wang,Zhiyuan Wang,Qibin Li et al.
Yameng Wang et al.
The special physiological barriers of women, such as vaginal mucus and self-cleaning behavior, pose great challenges for the treatment of vulvovaginal candidiasis (VVC), and the drug resistance caused by fungal biofilms limits the applicati...
Intracellular redistribution of cell-penetrating peptide p28: A mechanism for enhanced anti-cancer activity [0.03%]
细胞穿透性肽p28的胞内重新分布：提高抗癌活性的机制
Duy Binh Tran,Konstantin Christov,Sunam Mander et al.
Duy Binh Tran et al.
Cell-penetrating peptides (CPPs) have been studied as they provide an efficient strategy for the intracellular delivery of bioactive molecules in various biomedical applications such as cancer diagnosis and therapy. We have developed an ani...
Acetyl-lysine human serum albumin nanoparticles are taken up by CD44 receptors on cancer stem cells and this leads to tumor eradication, without recurrence [0.03%]
乙酰赖氨酸人血清白蛋白纳米颗粒被癌症干细胞上的CD44受体吸收，这导致肿瘤消除且不复发
Guojun Xiong,Andreas G Schätzlein,Ijeoma F Uchegbu
Guojun Xiong
CD44 receptors in cancer stem cells (CSCs) are a key biomarker associated with cancer recurrence, progression, and metastasis. Acetylation is a post-translational modification used to regulate protein function at the end of protein synthesi...
Poly-lysine-modified recombinant protein nanocages for effective delivery of small activating RNA [0.03%]
多聚赖氨酸修饰的重组蛋白纳米笼用于有效递送小激活RNA联合实验
Lixing Xu,Shanshan Li,Shen Wan et al.
Lixing Xu et al.
Small molecule activating RNA (saRNA) holds significant promise as a therapeutic platform for various diseases. However, the development of efficient nanocarriers that can overcome existing delivery challenges and ensure effective cellular ...
Delivery of a novel neuroprotective compound to the retina in rat and rabbit animal models [0.03%]
新型眼用神经营养化合物在大动物模型眼部的递送研究
Meredith Garrett,Stacy Curry,Sherri Feris et al.
Meredith Garrett et al.
Posterior segment-related diseases are among the leading causes of irreversible blindness and loss of vision globally. These diseases are extremely difficult to treat due to the drug delivery barriers posed by the eye, among other challenge...
Vasiliki Kolliopoulos,Antonios G Mikos
Vasiliki Kolliopoulos
Tissue engineering and regenerative medicine approaches seek to enhance biomaterial mimicry with the goal of driving cell recruitment, proliferation, and differentiation. Decellularized extracellular matrix (dECM) biomaterials have emerged ...
Corrigendum to 'Innovative injectable, self-healing, exosome cross-linked biomimetic hydrogel for cartilage regeneration' [Journal of Controlled Release, Volume 381 (2025), 113608] [0.03%]
《对“创新性可注射、自愈、外泌体交联的生物仿生水凝胶用于软骨再生”一文的勘误[控制释放杂志，第381卷（2025），113608]》
Chenlin Tu,Xiang Gao,Hong Zheng et al.
Chenlin Tu et al.
Biological effects of rapid short pulses of focused ultrasound for drug delivery to the brain [0.03%]
用于药物向脑内传递的快速短声脉冲的聚焦超声波的生物效应
Sophie V Morse,Sarah Rimer,Grainne Geoghegan et al.
Sophie V Morse et al.
Focused ultrasound in combination with intravenously injected microbubbles offers a non-invasive and localised method to deliver drugs across the blood-brain barrier, enabling targeted treatment of brain disorders. Recently, we have shown t...
Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer [0.03%]
与透明质酸酶连接的檞皮素脂质体：一种阻止胰腺癌的有效药物输送系统
Ge Sun,Ying Wu,Jiekai Li et al.
Ge Sun et al.
Pancreatic cancer characterized with intense hydraulic tissue in tumor extracellular matrix (ECM) resists most of chemotherapeutic drugs. Increased levels of hyaluronic acid (HA) represent the primary component of the hydraulic tissue, rend...
HER2-targeted star polymer conjugates for improved tumor distribution and efficacy [0.03%]
用于改善肿瘤分布和疗效的HER2靶向型星形聚合物连接体
Silvia Sonzini,Richard M England,Alexander N Kapustin et al.
Silvia Sonzini et al.
Actively targeted nanoparticle systems have the potential to improve delivery to tumors over untargeted systems however the design rules to achieve this have not been fully elucidated. A HER2-targeted polymer drug delivery system composed o...