Smart gel tectonics: 3D-printed starch-chitosan architectures with pH-responsive magnesium delivery for targeted intestinal repletion [0.03%]
智能凝胶构造：用于靶向肠道补充的PH值响应式镁输送三维印刷淀粉-壳聚糖架构
Qiyong Guo,Weihang Cao,Ling Chen
Qiyong Guo
The development of effective oral magnesium supplements is hindered by two major delivery challenges: rapid gastric leakage leading to gastrointestinal side effects, and non-targeted intestinal release resulting in poor absorption and compe...
A versatile self-adjuvanting macro-microporous ZIF-8@Mn MOF platform for efficient antigen capture and presentation to boost antitumor immunity [0.03%]
一种用于高效抗原捕获和呈递以增强抗肿瘤免疫的多功能自佐剂ZIF-8@Mn MOF宏微多孔平台
Qinhua Zuo,Linghong Huang,Yanping Wang et al.
Qinhua Zuo et al.
Personalized in situ tumor vaccines (ISTVs) have emerged as a promising approach to activating potent T cell-mediated anticancer immunity through the induction of immunogenic cell death (ICD) and the subsequent release of tumor-associated a...
Emily L DeWolf,Bernice Webber,Matthew J Webber
Emily L DeWolf
Biologic therapies for diabetes have advanced significantly through molecular engineering strategies that optimize therapeutic stability, pharmacokinetics, and delivery. This review presents an integrated overview of design principles used ...
Intrapericardial delivery of FAP-CAR-T cells via a ROS-responsive hydrogel to treat cardiac fibrosis [0.03%]
通过ROS响应性水凝胶递送FAP-CAR-T细胞进行心包内投药以治疗心脏纤维化
Bihui Cao,Manting Liu,Sainiwaer Anwaier et al.
Bihui Cao et al.
Cardiac fibrosis is a key pathological feature of both acute and chronic heart diseases, characterized by abnormal accumulation of extracellular matrix resulting from fibroblast activation. Although fibroblast activation protein (FAP)-targe...
A hydrogen generator enhances immunogenic transarterial chemoembolization in hepatocellular carcinoma [0.03%]
氢气发生器可增强免疫有动脉化疗栓塞治疗在肝细胞癌中的疗效
Lei Cao,Li Ren,Longlin Yin et al.
Lei Cao et al.
Conventional transarterial chemoembolization (TACE) regimens for hepatocellular carcinoma (HCC) are often compromised in efficacy due to hypoxia and acidosis within the tumor microenvironment (TME), frequently leading to unsatisfactory trea...
Unlocking component-level chemical structural information for AI-driven targeted nanoparticle design [0.03%]
用于AI驱动的靶向纳米粒子设计的组件级化学结构信息解析
Haomin Wu,Yu Cheng,Yuanhui Ji
Haomin Wu
The structural complexity and unpredictable in vivo fate of nanoparticles pose major barriers to rational design of targeted nanoparticles. The rapidly developing artificial intelligence (AI) technology brings new opportunities to establish...
Sonocatalytic multifunctional hydrogel in-situ remodels the infectious microenvironment for eradicating refractory osteomyelitis [0.03%]
声催化多功能水凝胶原位重塑感染微环境以根除难治性骨髓炎
Xinzi He,Yaping Li,Zhihui Xiang et al.
Xinzi He et al.
Osteomyelitis remains a formidable clinical challenge due to biofilm-associated antibiotic resistance, a hypoxic and immunosuppressive microenvironment, and progressive inflammatory bone destruction. To address these multifactorial barriers...
A robust RNAi nanoplatform for precise activation of cGAS-STING pathway and effective immune checkpoint blockade to potentiate cancer immunotherapy [0.03%]
一种有效的RNAi纳米平台精准激活cGAS-STING通路并有效阻断免疫检查点以增强癌症免疫疗法
Lei Xu,Zhuoshan Huang,Wenyue Zhang et al.
Lei Xu et al.
Activation of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-interferon gene stimulator (STING) pathway has demonstrated significant potential in cancer treatment due to its crucial role in bridging the innate and ad...
Dual-payload small-molecule drug conjugates enable bystander anticancer activity with reduced nonspecific release [0.03%]
双有效载荷的小分子药物偶联物可在减少非特异性释放的同时实现对旁观者细胞的抗癌作用
Chuanjie Chen,Yongzhang Pan,Na Zhang et al.
Chuanjie Chen et al.
Small-molecule drug conjugates (SMDCs) have emerged as a promising class of targeted therapeutics, yet their clinical translation has been hindered by suboptimal efficacy and safety, with conventional optimization largely restricted to vari...
A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds [0.03%]
一种精确释放一氧化氮的水凝胶促进纳米颗粒渗透，以全面恢复糖尿病伤口的神经-血管并调节微环境
Lu Enhao,Huang Xueli,Zhang Qi et al.
Lu Enhao et al.
Peripheral neuropathy and microcirculation distribution are key causes of diabetic foot ulcers (DFUs). Based on the vessel dilation and nerve regeneration effect of nitric oxide (NO), a multi-functional nanoparticles-hydrogel therapy system...