Characterising the time-course of microvascular vasodilator responses in humans using Laser Doppler Fluximetry and iontophoresis [0.03%]
利用激光多普勒流血计和电渗法描述人体微血管 vasodilator 反应的时间过程
Markos Klonizakis,Krishna Lingam,Gillian Manning et al.
Markos Klonizakis et al.
Introduction: Laser Doppler Fluximetry (LDF) and iontophoresis of vasodilators have been combined to assess microvascular flow and vasodilator reactivity in humans for many years and their use established. However, tradit...
Welfare of the minipig with special reference to use in regulatory toxicology studies [0.03%]
小型猪福利的特殊参考：用于法规毒理学研究中
Lars Ellegaard,Andrew Cunningham,Sandra Edwards et al.
Lars Ellegaard et al.
This paper reviews the animal welfare challenges associated with the use of minipigs in toxicology testing, and compares these to published knowledge on the other widely used non-rodent species (dogs and non-human primates). Welfare challen...
Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice [0.03%]
评估安全药理学研究中一种便捷的评价啮齿类动物视力的方法：碘化钠对白毛和黑毛大鼠和小鼠视锐度及视网膜形态的影响
William S Redfern,Sharon Storey,Karen Tse et al.
William S Redfern et al.
Introduction: We have evaluated the ability of a semi-automated, optomotor reflex method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice. ...
Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products [0.03%]
小型猪在药物、化学品和其他产品开发中的监管适用性
Jan Willem van der Laan,John Brightwell,Peter McAnulty et al.
Jan Willem van der Laan et al.
As part of the RETHINK European FP6 Project an overview of the acceptability and usefulness of minipigs has been carried out in the regulatory arenas of human and veterinary pharmaceuticals, food additives, cosmetics, biocides and agrochemi...
EEG in the FEAB model: measurement of electroencephalographical burst suppression and seizure liability in safety pharmacology [0.03%]
FEAB模型中的EEG检测：安全药理学中的脑电图爆发抑制和癫痫发作易感性测量
H J van der Linde,B Van Deuren,Y Somers et al.
H J van der Linde et al.
Introduction: The purpose of this study was to explore the integration of electroencephalographical (EEG) measurements into the fentanyl/etomidate-anaesthetised Beagle (FEAB) model in order to detect burst suppression and...
Non-clinical models: validation, study design and statistical consideration in safety pharmacology [0.03%]
非临床模型：安全药理学中的验证、实验设计和统计考虑因素
M K Pugsley,R Towart,S Authier et al.
M K Pugsley et al.
The current issue of the Journal of Pharmacological and Toxicological Methods (JPTM) focuses exclusively on safety pharmacology methods. This is the 7th year the Journal has published on this topic. Methods and models that specifically rela...
Evaluation of respiratory function in freely moving Beagle dogs using implanted impedance technology [0.03%]
植入式阻抗技术在自由活动的比格犬上评价呼吸功能
Kenneth Kearney,Monica Metea,Teresa Gleason et al.
Kenneth Kearney et al.
Introduction: The Safety Pharmacology ICH S7A guidelines mandate the preclinical evaluation of drug effects on respiratory function. Chronic measurements of potential drug effects are commonly performed in rodents due to ...
Arrhythmogenic liability screening in cardiovascular safety pharmacology: commonality between non-clinical safety pharmacology and clinical thorough QT (TQT) studies [0.03%]
心律失常易患性在心血管安全药理学中的筛查：非临床安全药理学与临床全面QT间期研究的共通性
Simon Authier,Michael K Pugsley,Eric Troncy et al.
Simon Authier et al.
Multiple ECG analysis strategies are used in safety pharmacology in a framework focused on accurate ECG complex interval quantification and arrhythmia detection. Automated arrhythmia detection is commonly used in the clinic and adapted tool...
An integrated cardiovascular and neurobehavioural functional assessment in the conscious telemetered cynomolgus monkey [0.03%]
清醒状态下食蟹猴遥测的一体化心脑功能评价模型研究进展
Elena Moscardo,Gordon McPhie,Nicola Fasdelli et al.
Elena Moscardo et al.
Introduction: Unwanted effects of drugs on neurobehavioural and cardiovascular functions are normally assessed in separate studies and using different animals. The purpose of this study was to validate, in the monkey, a m...
Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp [0.03%]
评估PatchXpress自动化膜片钳技术检测心肌Na+电流的使用依赖性抑制作用
Jacob R Penniman,David C Kim,Joseph J Salata et al.
Jacob R Penniman et al.
Introduction: The cardiac Na+ current (I(Na)) underlies the rapid depolarization of the cardiac myocyte, and block of the current slows cardiac conduction and increases the risk of ventricular arrhythmia. A feature of Na+...