Development of spectroscopic methods using charge transfer complex for the quantitative estimation of proguanil hydrochloride: Insights from greenness evaluation, BSA binding, molecular docking, antimicrobial studies and Insilico toxicity assessment [0.03%]
基于电荷转移复合物的光谱法测定氢氯喹羟片的定量方法研究：来自绿色度评价，BSA结合，分子对接，抗菌研究和Insilico毒性评估的见解
Abdullah Mannan,Adila Khalil,Mohammad Kashif et al.
Abdullah Mannan et al.
Analytical methods utilizing the donor-acceptor phenomenon for proguanil (PRGL), an antimalarial medication, that are straightforward, quick, and possess a wide linear dynamic range for drug quantification and its toxicity assessment have n...
Advancing safety pharmacology: Emerging technologies, innovative methods, and future directions [0.03%]
迈向安全药理学的未来：新兴技术、创新方法及发展方向
Michael K Pugsley,Brett R Winters,Lutfiya Miller et al.
Michael K Pugsley et al.
This editorial introduces the annual themed issue of the Journal of Pharmacological and Toxicological Methods (JPTM) dedicated to methodologies in safety pharmacology. The issue draws on content presented at the 2025 Safety Pharmacology Soc...
Detecting drug-induced EEG alterations with machine learning: A methodological proof-of-concept study in rats treated with MK-801 [0.03%]
基于机器学习的药物诱导EEG改变检测方法的确证研究——以氯胺酮为例
Matthieu Basset,Paul-Emeric Saunier,Geoffrey Viardot et al.
Matthieu Basset et al.
Introduction: Although deep learning methods for electroencephalogram (EEG) analysis are rapidly advancing, architectures developed for human multichannel recordings may not be suited to animal EEG, where recordings typic...
Predicting thorough QT safety profile using hERG IC10 versus IC50 [0.03%]
预测心脏毒性作用的QT综合症的安全轮廓采用hERG IC10代替IC50
Andrew G Edwards,William J Crumb Jr
Andrew G Edwards
The human ether-à-go-go-related gene (hERG) K+ channel is the principal off-target mediator of drug-induced QT prolongation, and hERG IC50 remains the only required in vitro cardiac safety assay. However, clinically relevant QT prolongatio...
In silico study: ADMET-driven pharmacokinetic profiling of antiviral compounds for pre-clinical screening framework of intranasal drug development [0.03%]
基于ADMET的抗病毒药物药代动力学筛选模型的计算机辅助研究
Jeerakit Kerdsiri,Tasana Pitaksuteepong,Neal M Davies et al.
Jeerakit Kerdsiri et al.
The ongoing emergence of respiratory viral pathogens, including novel variants and established threats such as influenza, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Respiratory Syncytial Virus (RSV), continues to chal...
Redefining cardiovascular safety: A dual-pathway, mechanistic in silico screen for the detection of trafficking-mediated and "hidden" cardiotoxicity [0.03%]
重新定义心血管安全性：一种双重途径的、基于机制的“体内”筛查方法，用于检测转运介导型和“隐藏型”心脏毒性
Mustafa Al Yagoub
Mustafa Al Yagoub
Background: The Comprehensive in vitro Proarrhythmia Assay (CiPA) shifted cardiovascular safety assessment from binary hERG testing toward mechanistic multichannel integration. A key blind spot remains: many workflows tre...
From surplus to scientific value: Repurposing vascular tissues for organ bath standardization to de-risk vasoactive liabilities [0.03%]
从剩余组织到科学价值：重新利用血管组织进行器官浴标准化以降低血管活性风险
Laura Coonen,Cristina Altrocchi,Jeroen Tolboom et al.
Laura Coonen et al.
Introduction: The vascular organ bath assay is a well-established classical pharmacology model to characterize vasoactive properties of compounds, offering a platform to elucidate mechanisms of action, optimize dosing, an...
Advances in microfluidic endothelium-on-chip for assessing endothelial function [0.03%]
芯片上微流体内皮在评估内皮功能方面的进展
Belay Tesfamariam,Natalie J Miller
Belay Tesfamariam
Vascular interventions can damage the endothelial glycocalyx and disrupt endothelial junction proteins, potentially leading to thrombosis, increased vascular permeability and the transmigration of leukocytes and lipoproteins. Drug-coated en...
Analytical performance of poly(L-cysteine) modified pencil graphite electrode for Dapsone detection [0.03%]
聚L-半胱氨酸修饰的铅笔石墨电极测定达卢凡尔磺胺的分析性能研究
Santosh B Konnur,Jayant I Gowda,Sharanappa T Nandibewoor
Santosh B Konnur
The electrochemical analysis of Dapsone (DP) was carried out using a poly-L-cysteine (poly-L-Cys) modified pencil graphite electrode (poly-L-Cys/PGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The method was optimi...
Corrigendum to "Nonclinical cardiovascular safety assessment of thioridazine: Impact of heart rate, body temperature, and choice of species" [Journal of Pharmacological and Toxicological Methods, Volume 115 (2022), 107167] [0.03%]
关于“非临床抗心律失常药物的卡巴丁酮的心血管安全性评估：心率、体温和物种选择的影响”[《药理学与毒理学方法杂志》，2022年，第115卷，107167] 的勘误通知
Andrea Greiter-Wilke,Sonia Roberts,Katja Heinig et al.
Andrea Greiter-Wilke et al.