Analytical performance of poly(L-cysteine) modified pencil graphite electrode for Dapsone detection [0.03%]
聚L-半胱氨酸修饰的铅笔石墨电极测定达卢凡尔磺胺的分析性能研究
Santosh B Konnur,Jayant I Gowda,Sharanappa T Nandibewoor
Santosh B Konnur
The electrochemical analysis of Dapsone (DP) was carried out using a poly-L-cysteine (poly-L-Cys) modified pencil graphite electrode (poly-L-Cys/PGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The method was optimi...
Corrigendum to "Nonclinical cardiovascular safety assessment of thioridazine: Impact of heart rate, body temperature, and choice of species" [Journal of Pharmacological and Toxicological Methods, Volume 115 (2022), 107167] [0.03%]
关于“非临床抗心律失常药物的卡巴丁酮的心血管安全性评估：心率、体温和物种选择的影响”[《药理学与毒理学方法杂志》，2022年，第115卷，107167] 的勘误通知
Andrea Greiter-Wilke,Sonia Roberts,Katja Heinig et al.
Andrea Greiter-Wilke et al.
Rapid and sensitive quantification of pemetrexed in human plasma by LC-MS/MS using a stable isotope-Labeled internal standard for therapeutic drug monitoring [0.03%]
一种用于治疗药物监测的稳定的同位素标记的内标及LC-MS/MS快速灵敏测定人血浆中培美曲塞的方法
Haoran Yang,Huimin Yu,Tang Tang et al.
Haoran Yang et al.
Objective: To develop and validate a reliable LC-MS/MS method for quantifying pemetrexed in human plasma to investigate exposure-toxicity relationships. M...
The INSPIRE doctoral network in safety pharmacology - Looking back and ahead [0.03%]
安全药理学INSPIRE博士网络——回顾与展望
Pieter-Jan Guns,Brigitta Rita Szabó,Martina Cherubin et al.
Pieter-Jan Guns et al.
The INSPIRE project, funded by the European Marie Skłodowska-Curie Action (MSCA) program, was a doctoral network designed to train early-stage researchers (ESRs) and stimulate exploratory research in cardiovascular safety pharmacology (SP)...
NADES-assisted sustainable extraction of total protein content from Achyranthes bidentata seeds and their biochemical characterization [0.03%]
NADES辅助的Bidens biternata种子总蛋白含量可持续提取及生物化学特性分析
Premraj Kailas Salunkhe
Premraj Kailas Salunkhe
This study evaluates Natural Deep Eutectic Solvents (NADES) as sustainable alternatives for the extraction of proteins and phytochemicals from Achyranthes bidentata seeds. Six lactic acid-based NADES formulations were compared against water...
Non-invasive, home cage digital monitoring for improved safety pharmacology assessments in drug development: ICH S7A update considerations [0.03%]
无需捕获的小动物非侵入式全笼数字化监测技术在药物研发中的安全药理学评估应用：关于ICH S7A更新的考量
Brian R Berridge,Chang-Ning Liu,Ajeesh K Cherian et al.
Brian R Berridge et al.
Non-invasive digital sensors are rapidly evolving in their capabilities and applications in both humans and animals. The dynamic and continuous biological insights they provide are likely to re-define our understanding of human and animal h...
Machine learning modeling of acute inhalation toxicity using an RFA-RFR framework, supported by explainable AI and SALI-based activity cliff analysis [0.03%]
基于RFA-RFR框架的急性吸入毒性机器学习模型及其可解释AI和SALI基活性悬崖分析支持
Vijay H Masand,M M Rathore,Jayant R Bansod et al.
Vijay H Masand et al.
The present study develops machine learning models to predict the acute inhalation toxicity (pLC₅₀) of a diverse set of 552 molecules. Following dataset curation from the Integrated Chemical Environment (ICE) database, 3D molecular struct...
A robust FRET-based biochemical assay for the discovery of chikungunya virus nsP2 protease inhibitors [0.03%]
一种用于发现基孔肯雅病毒nsP2蛋白酶抑制剂的鲁棒型FRET生化测定法
Jiankai Ye,Chunlei Xu,Jiahao Zhou et al.
Jiankai Ye et al.
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is a significant global health concern, yet no approved antiviral drugs exist. The nsP2 protease, which processes viral polyproteins into functional units for virus replication, repres...
The emerging use of artificial intelligence in safety pharmacology & toxicology [0.03%]
人工智能在安全药理学和毒理学中的应用不容忽视
Lutfiya Miller,Ian Treleaven,Abdel-Ilah El Amrani et al.
Lutfiya Miller et al.
Safety pharmacology is concerned with the identification and characterization of adverse effects of drug candidates on vital organ systems. The emergence of artificial intelligence (AI) and machine learning (ML) has prompted growing interes...
Detection capabilities of a single dried blood spot for recombinant erythropoietin micro-dose testing in sport [0.03%]
单次干血点检测在体育中用于重组促红细胞生成素微量剂量检测的能力
L Requena-Tutusaus,I Anselmo,S Coll et al.
L Requena-Tutusaus et al.
Objectives: Dried blood spot (DBS) micro-sampling is gaining prominence in anti-doping testing, particularly for the detection of erythropoietin-receptor agonists (ERAs) such as recombinant erythropoietin (rEPO). However,...