Sampling port for real-time analysis of bioaerosol in whole body exposure system for animal aerosol model development [0.03%]
用于动物气溶胶模型发展的全身暴露系统中生物气溶胶实时分析取样口的研究
Divey Saini,Gregory W Hopkins,Ching-Ju Chen et al.
Divey Saini et al.
Introduction: Multiple factors influence the viability of aerosolized bacteria. The delivery of aerosols is affected by chamber conditions (humidity, temperature, and pressure) and bioaerosol characteristics (particle num...
Robert L Hamlin
Robert L Hamlin
A pharmacokinetic-pharmacodynamic model for cardiovascular safety assessment of R1551 [0.03%]
一种R1551药物的心血管安全性评价的药代-药效模型
Angèle Fleury,Thierry Lavé,Fredrik Jonsson et al.
Angèle Fleury et al.
Introduction: Pharmacokinetic-pharmacodynamic relationships are crucial in understanding a drug's arrhythmogenic potential. Models assist to quantitatively relate parent and metabolite concentrations to adverse electrocar...
Glutamate and aspartate measurements in individual planaria by rapid capillary electrophoresis [0.03%]
通过快速毛细管电泳测定单个_planaria_中的谷氨酸和天冬氨酸含量
Chandni A Vyas,Scott M Rawls,Robert B Raffa et al.
Chandni A Vyas et al.
Introduction: Planaria present a unique model organism for studying primitive central nervous systems. The major mammalian excitatory neurotransmitters, glutamate and aspartate, have previously been measured in planaria v...
The RETHINK project: impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity testing [0.03%]
RETHINK项目：作为监管毒理学测试替代方法的Mini猪毒性试验的影响
Michael J Curtis
Michael J Curtis
The RETHINK project--minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment [0.03%]
RETHINK项目：小型猪作为新药和化学品毒性检测模型的影响评估
Roy Forster,Gerd Bode,Lars Ellegaard et al.
Roy Forster et al.
The objective of the RETHINK project was to evaluate the potential impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity testing that can contribute to the replacement, refinement and reduction of anima...
Roy Forster,Philippe Ancian,Merete Fredholm et al.
Roy Forster et al.
The potential of the minipig as a platform for future developments in genomics, high density biology, transgenic technology, in vitro toxicology and related emerging technologies was reviewed. Commercial interests in the pig as an agricultu...
Gerd Bode,Peter Clausing,Frederic Gervais et al.
Gerd Bode et al.
In this article we review the value and utility of the minipig as an animal model in regulatory toxicity testing. Our review is based on detailed consideration of the comparative biology of the minipig, and of the practical features of toxi...
The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations [0.03%]
关于在新药和化学品毒性试验中重新思考使用迷你猪的项目：结论与建议
Roy Forster,Gerd Bode,Lars Ellegaard et al.
Roy Forster et al.
The objective of the RETHINK project was to evaluate the potential impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity testing that can contribute to the replacement, refinement and reduction of anima...
Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits [0.03%]
validations of 123I-MIBG作为兔血小板标记物的非侵入性成像标志物的验证
Hom N S Saihkay,Karen J Rickards,Clive P Page et al.
Hom N S Saihkay et al.
Introduction: Recent in vitro studies in our laboratory have demonstrated that platelets are necessary for leukocyte recruitment and airway remodelling in models of allergic airway inflammation, and also migrate to lung t...