Victoria Vinader,Yousef Al-Saraireh,Helen L Wiggins et al.
Victoria Vinader et al.
Introduction: Chemokines are important players in directing the migration of cancer cells as part of the metastatic process. The aim of this study is to develop an easy-to-perform, reliable, and inexpensive assay for rapi...
Idiopathic pulmonary arterial hypertension: an avian model for plexogenic arteriopathy and serotonergic vasoconstriction [0.03%]
特发性肺动脉高压： Plexogenic 动脉病和血清素血管收缩的禽类模型
Robert F Wideman Jr,Krishna R Hamal
Robert F Wideman Jr
Idiopathic pulmonary arterial hypertension (IPAH) is a disease of unknown cause that is characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance attributable to vasoconstriction and vascular remodeling of smal...
Quantitative immunofluorescent blotting of the multidrug resistance-associated protein 2 (MRP2) [0.03%]
多药耐药相关蛋白2(MRP2)的定量免疫荧光印迹法
Phillip M Gerk
Phillip M Gerk
Introduction: Quantitation of the expression levels of proteins involved in drug transport and disposition is needed to overcome limitations of film-based detection of chemiluminescent immunoblots. ...
A step towards characterisation of electrophysiological profile of torsadogenic drugs [0.03%]
向描述促扭转型药物电生理特征的一步
Pascal Champeroux,Aude Ouillé,Eric Martel et al.
Pascal Champeroux et al.
Introduction: In a previous study, two electrophysiological patterns for torsadogenic drugs were characterised in the model of isolated canine Purkinje fibres from their respective effects on action potential. This study ...
Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical [0.03%]
利多卡因和丙吡胺致心脏钠离子通道抑制及心室传导阻滞的非临床模型向临床转化研究的翻译
B M Heath,Y Cui,S Worton et al.
B M Heath et al.
Introduction: Nonclinical in vivo models used for cardiovascular safety testing have not previously been studied for their sensitivity for detection of conduction slowing resulting from cardiac sodium channel block. The g...
Generation of a panel of monoclonal antibodies against atypical chemokine receptor CCX-CKR by DNA immunization [0.03%]
利用DNA免疫法得到针对非典型趋化因子受体CCX-CKR的单克隆抗体文库
Shogo Takatsuka,Aya Sekiguchi,Masayuki Tokunaga et al.
Shogo Takatsuka et al.
Introduction: Chemokines are regulated by a family of 'atypical' chemokine receptors, D6, DARC and CCX-CKR, each of which efficiently internalizes its cognate chemokine ligands. Development of monoclonal antibodies (MAbs)...
Development of a murine model of lymph node metastases suitable for immunotoxicity studies [0.03%]
适用于免疫毒理学研究的淋巴结转移小鼠模型的建立
Devon D Egenolf,Patricia Rafferty,Kerry Brosnan et al.
Devon D Egenolf et al.
Introduction: Immunosuppressive drugs are associated with an increased risk of infections and in some cases neoplasia, particularly non-melanoma skin cancers. This paper describes the development of a model to test the ef...
Application of miniaturized immunoassays to discovery pharmacokinetic bioanalysis [0.03%]
微型免疫测定在发现药代动力学生物分析中的应用
Jeanette Roman,Julia Qiu,Geethanjali Dornadula et al.
Jeanette Roman et al.
Introduction: Pharmacokinetic properties of biotherapeutics are an important aspect of preclinical drug development. The lead identification and optimization space is characterized by aggressive timelines, large sample nu...
Rapid detection of ABC transporter interaction: potential utility in pharmacology [0.03%]
ABC转运蛋白相互作用的快速检测：在药理学中的潜在应用价值
Robert W Robey,Bo Lin,Jean Qiu et al.
Robert W Robey et al.
Introduction: The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) are known to transport a wid...
Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2 [0.03%]
人肝细胞培养物中化合物介导的CYP3A4、CYP2B6和CYP1A2诱导对细胞色素P450活性的同步评估
Susan P Rhodes,Jennifer N Otten,Gary P Hingorani et al.
Susan P Rhodes et al.
Introduction: The human nuclear receptors pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR) are known to regulate gene expression of the cytochrome P450 (CYP) enzymes, ...