ECG arrhythmias in non-implanted vs. telemetry-implanted dogs: need for screening before and sufficient recovery time after implantation [0.03%]
植入心电监测仪前后犬的节律异常：植入前筛查及植入后充分恢复时间的必要性
Frank Cools,Sigrid Janssens,Annik Vanlommel et al.
Frank Cools et al.
Introduction: The purpose of this study was: (1) to characterize and assess the incidence of spontaneous arrhythmias in totally naive Beagle dogs (n=51; 10 males+41 females): (2) to study the effects of permanent ECG- and...
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles [0.03%]
采用生物阻抗无创检测心脏指数代替侵入性检测用于比格犬的临床前药物评价
Paul M Heerdt,Christa L Wagner,Marissa DeMais et al.
Paul M Heerdt et al.
Introduction: Non-invasive measurement of cardiac output (CO) using bioreactance signals (NICOM) was recently validated in swine and human adults. The present study was designed to test the hypothesis that NICOM flow meas...
Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds [0.03%]
心室率适应性：一种新颖、快速的细胞基质体外试验方法，用于识别促心律失常和尖端扭转性化合物
Jonathon R Green,Gilbert J Diaz,James T Limberis et al.
Jonathon R Green et al.
Introduction: Delayed cardiac repolarization is an established risk factor for proarrhythmia and Torsades-de-Pointes (TdeP) that is typically measured in vitro during slow, regular stimulation. We have developed an altern...
An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice [0.03%]
自动化评估系统分析辣椒素引起的肠内脏疼痛相关的舔吸行为的镇痛作用
Etsuko Hayashi,Tomohiro Kobayashi,Yasuteru Shiroshita et al.
Etsuko Hayashi et al.
Introduction: The development of automated detection systems for animal behaviors is increasing in value in terms of saving time, objective analysis and reducing the need for well-trained experimenters. SCLABA(®) (Novelt...
Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys [0.03%]
莫西沙星对仪器猴QTc延长的药代动力学-药效学模型研究
Kenny J Watson,William P Gorczyca,John Umland et al.
Kenny J Watson et al.
Introduction: Delayed ventricular repolarisation is manifested electrocardiographically in a prolongation of the QT interval. Such prolongation can lead to potentially fatal Torsades de Pointes. Moxifloxacin is a fluoroqu...
Continuous evaluation of drug withdrawal in the rat using telemetry: effects of morphine and chlordiazepoxide [0.03%]
应用遥测技术连续评价药物停药反应的慢性动物模型——阿片类和苯二氮卓类药物的作用研究
Christelle Froger-Colléaux,Sonia Rompion,Philippe Guillaume et al.
Christelle Froger-Colléaux et al.
Introduction: The procedures used to assess withdrawal must be sensitive and widely applicable, i.e. not specific to any particular drug class. Furthermore, the measurements should not be affected by repeat testing. ...
Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies [0.03%]
在啮齿类动物安全药理研究中评价运动活性方法的比较
James J Lynch rd,Vincent Castagné,Paul C Moser et al.
James J Lynch rd et al.
Introduction: General neurobehavioral assays, like a modified Irwin test or a functional observational battery, are necessary for central nervous system (CNS) safety pharmacology testing near the end of the target validat...
Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors [0.03%]
用于选择性MMP-13抑制剂体内早期筛选的肌骨症(MSS)功能生物标志物
Suzanne G Nodop Mazurek,Jun Li,Gerald H Nabozny et al.
Suzanne G Nodop Mazurek et al.
Introduction: Long-term administration of non-selective matrix metalloproteinase (MMP) inhibitors, such as marimastat, in humans elicits musculoskeletal syndrome (MSS), a syndrome characterized by joint damage including p...
Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey [0.03%]
caracterization and validation of a streptozotocin-induced diabetes model in the vervet monkey vervet猴的链佐星诱导糖尿病模型的特征及验证
Kylie Kavanagh,David M Flynn,Chris Nelson et al.
Kylie Kavanagh et al.
Introduction: Streptozotocin (STZ), preferentially toxic to pancreatic beta cells, is commonly used to model Type 1 diabetes mellitus (DM) in numerous species, including nonhuman primates. ...
L J Shiry,R L Hamlin
L J Shiry
Introduction: The high pressure baroreceptor reflex rapidly buffers changes in systemic arterial pressure in response to postural changes, altered gravitational conditions, diseases, and pharmacological agents. Drug-induc...