Trends in safety pharmacology: posters presented at the annual meetings of the Safety Pharmacology Society 2001-2010 [0.03%]
安全药理学趋势：安全药理学会2001至2010年年会上的墙报论文
William S Redfern,Jean-Pierre Valentin
William S Redfern
Introduction: The inaugural meeting of the Safety Pharmacology Society (SPS) was in 2001, soon after ICH S7A had been adopted. The 10th anniversary is an appropriate milestone at which to analyse trends in the science and...
Heart rate correction models to detect QT interval prolongation in novel pharmaceutical development [0.03%]
新药研发中用于检测qt间期延长的心率校正模型
Michael Markert,Ruijun Shen,Thomas Trautmann et al.
Michael Markert et al.
Introduction: The QT interval of the electrocardiogram (ECG) reflects the duration of ventricular depolarization and repolarization. A drug-induced prolongation of ventricular repolarization, and thereby QT prolongation, ...
Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts [0.03%]
保持心律——隔离哥廷根小猪心脏的促心律失常调查研究
Morten Laursen,Morten Grunnet,Søren-Peter Olesen et al.
Morten Laursen et al.
Introduction: Cardiac arrhythmia is a potentially lethal condition. A better prediction and mechanistic understanding of human cardiac arrhythmia is dependent on the development of good animal models. Minipigs are increas...
Using pharmacokinetic modeling to determine the effect of drug and food on gastrointestinal transit in dogs [0.03%]
应用药代动力学模型确定药物和食物对犬胃肠道转运的影响
Linnea Sjödin,Sandra Visser,Ahmad Al-Saffar
Linnea Sjödin
Introduction: The gastrointestinal (GI) tract is one of the target organs of adverse drug effects in different phases of drug development. This study aimed to investigate the feasibility of population pharmacokinetic mode...
Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization [0.03%]
戈特инг根迷你猪的心血管和呼吸系统安全药理学：药理特征描述
S Authier,J Gervais,S Fournier et al.
S Authier et al.
Introduction: Similarities between pigs and humans support the relevance of Göttingen minipigs for regulatory safety pharmacology. The minipig is the species of choice for cardiovascular safety pharmacology when pivotal ...
J Pedro Veiga,Patricia A Cooper,Klaus Pors et al.
J Pedro Veiga et al.
Introduction: The preclinical development and clinical progression of potential anticancer agents are highly time and resource-intensive. Traditionally, promising compounds in vitro undergo further screening in xenograft ...
Characterisation of rodent dobutamine echocardiography for preclinical safety pharmacology assessment [0.03%]
用于临床前安全药理学评估的啮齿类动物多巴胺超声心动图的表征研究
Marcello Tontodonati,Nicola Fasdelli,Paolo Repeto et al.
Marcello Tontodonati et al.
Introduction: Dobutamine stress echocardiography (DSE) is performed to detect subtle ischemic regions in the myocardium in patients suffering from stenosed coronary artery disease. While in a clinical and veterinary conte...
Use of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research [0.03%]
基质辅助激光解析电离飞行时间质谱技术及其在临床肿瘤研究中的应用进展
Hannah Bateson,Saira Saleem,Paul M Loadman et al.
Hannah Bateson et al.
Cancer significantly affects millions of people worldwide. It is possible to use proteomic techniques to aid in detection, monitoring of treatment and progression, as well as gaining an increased understanding of cancer. Matrix-assisted las...
Natural Products Genomics: A novel approach for the discovery of anti-cancer therapeutics [0.03%]
天然产物基因组学——一种抗癌药物发现的新方法
N R Monks,B Li,S Gunjan et al.
N R Monks et al.
Plants continue to retain some advantages over combinatorial chemistry as sources of novel compounds, for example, they can generate metabolites with a complexity beyond synthetic chemistry. However, this comes with its own problems in prod...
Combination of ELISA and dried blood spot technique for the quantification of large molecules using exenatide as a model [0.03%]
联合使用酶联免疫吸附法和干血点技术对大分子进行定量分析——以艾塞那肽为模型化合物
Yong-Qing Lin,Risha Khetarpal,Yilu Zhang et al.
Yong-Qing Lin et al.
Introduction: To explore the feasibility of coupling dried blood spot (DBS) technique with ELISA for the quantification of large molecules, exenatide was used as a model. A method for the quantification of exenatide in hu...