Target organ identification of jellyfish envenomation using systemic and integrative analyses in anesthetized dogs [0.03%]
利用全身和综合分析麻醉狗箱形水母刺伤的目标器官识别
Changkeun Kang,Young Ki Kim,Hyunkyoung Lee et al.
Changkeun Kang et al.
Proper treatment of jellyfish envenomed patients can be successfully achieved only from an understanding of the overall functional changes and alterations in physiological parameters under its envenomation. The majority of previous investig...
In vivo laboratory practicals in research-led teaching: an example using glucose tolerance tests in lean and obese mice [0.03%]
基于研究的教学中的活体实验课——以小鼠葡萄糖耐量测试为例
Aileen J F King,James E Bowe,Juliet A Sprake et al.
Aileen J F King et al.
The use of animal models is an essential part of medical research and drug development. The essential skills required to be able to do such research includes experimental design, statistical analysis and the actual handling and treating of ...
Roberta d&#x;Emmanuele di Villa Bianca,Emma Mitidieri,Vincenzo Mirone et al.
Roberta d&#x;Emmanuele di Villa Bianca et al.
Introduction: Nitric oxide (NO) acts a pleiotropic biomodulator in several systems, including the cardiovascular, nervous and immune systems. The intracellular levels of cyclic guanylate monophosphate (cGMP) can be increa...
Automated blood sampling to identify pharmacodynamics biomarkers of corticotrophin releasing factor receptor 1 antagonism [0.03%]
自动化采血以识别皮质醇释放因子受体1拮抗剂的药动学生物标志物
S D Katugampola,R Fish,C Wood et al.
S D Katugampola et al.
Introduction: The aim of this study was to use an automated blood sampling technique to measure soluble hormones following an ovine corticotrophin releasing factor (oCRF) challenge using pharmacological doses that signifi...
Prolonged incubation and stacked film exposure improve sensitivity in western blotting [0.03%]
延长孵育时间和叠层膜曝光可提高 Western 印迹的灵敏度
Haitao Luo,Gary O Rankin,Shannon Straley et al.
Haitao Luo et al.
Introduction: Western blotting is a basic technique for protein detection. For proteins of less abundance or antibodies of poorer quality, an increased sensitivity is often desired. Although it is commonly known that high...
Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society [0.03%]
安全药理学的过去和未来：为了纪念安全药理学会成立十周年而对过去的十年进行回顾并展望近期、中期及远期前景
Alan S Bass,Hugo M Vargas,Jean-Pierre Valentin et al.
Alan S Bass et al.
In recognition of the tenth anniversary of the Safety Pharmacology Society (SPS), this review summarizes the significant events of the past 10years that have led to the birth, growth and evolution the SPS and presents a roadmap to the immed...
In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography [0.03%]
双平面数字减影血管造影在大鼠冠状动脉体内成像中的应用研究
Cristian T Badea,Laurence W Hedlund,Yi Qi et al.
Cristian T Badea et al.
Introduction: X-ray based digital subtraction angiography (DSA) is a common clinical imaging method for vascular morphology and function. Coronary artery characterization is one of its most important applications. We show...
Evaluation of a novel ECG lead placement method in telemetered freely moving cynomolgus monkeys: assessment of an intravascular biopotential lead [0.03%]
一种新型心电图导联放置方法在遥测条件下自由活动猕猴中评价：血管内生物电位电极评估
S Authier,L B Moon,M Stonerook et al.
S Authier et al.
Introduction: ECG is considered as a critical biomarker of cardiac safety pharmacology. ECG signal quality is essential for accurate interval quantification and automated arrhythmia detection. ...
M K Pugsley,R Towart,S Authier et al.
M K Pugsley et al.
This issue of the Journal of Pharmacological and Toxicological Methods (JPTM) is themed. It is the eighth in a series, arising from the Annual Safety Pharmacology Society (SPS) meeting. The SPS is now in its 10th year as an independent bran...
Evaluation of an algorithm for highly automated measurements of QT interval [0.03%]
一种自动测量QT间期算法的评价研究
Marina Brockway,Robert Hamlin
Marina Brockway
Introduction: Noise, artifact, and labile morphology of ECGs collected from freely moving animals in safety pharmacology studies render accurate measurements of QT interval challenging. Consequently, a high percentage of ...