Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade [0.03%]
基于hERG和NaV1.5阻滞的中通量电生理筛选中冷冻细胞系的应用价值评估
Brian T Donovan,Tania Bakshi,Sarah E Galbraith et al.
Brian T Donovan et al.
Introduction: The development of drug candidates must take into account that many compounds have off-target activity against voltage-gated ion channels (VGIC) which may prevent their progression to market. Of particular c...
An optimized method to assess in vivo efficacy of antithrombotic drugs using optical coherence tomography and a modified Doppler flow system [0.03%]
一种使用光学相干层析技术以及改良的多普勒流检测系统来优化评估抗凝血药物体内疗效的方法
L Couture,L P Richer,C Cadieux et al.
L Couture et al.
Introduction: Animal models of venous and arterial thrombosis are extremely useful to study the efficacy of antithrombotic agents. Variability in efficacy data is often observed in those preclinical studies. The goal of t...
Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: current recommendations from the Safety Pharmacology Society [0.03%]
药物开发中的安全药理学学会关于心血管非临床评价的最佳实践的当前推荐建议
D J Leishman,T W Beck,N Dybdal et al.
D J Leishman et al.
A cardiovascular safety pharmacology assessment is routinely conducted prior to first administration of a new chemical entity or biopharmaceutical to man. These assessments are used to inform clinicians of potential effects in those initial...
Functional properties and substrate characterization of human CYP26A1, CYP26B1, and CYP26C1 expressed by recombinant baculovirus in insect cells [0.03%]
用人重组杆状病毒假病毒感染昆虫细胞表达的三种人CYP26的功能特性及其作用底物的特征分析
Christian Helvig,Mohammed Taimi,Don Cameron et al.
Christian Helvig et al.
Introduction: The cytochrome P450 CYP26 family of retinoic acid (RA) metabolizing enzymes, comprising CYP26A1, CYP26B1, and CYP26C1 is critical for establishing patterns of RA distribution during embryonic development and...
hERG potency estimates based upon dose solution analysis: What have we learned? [0.03%]
基于剂量溶液分析的心脏毒性评价:HERG钾离子通道的价值何在？
Yusheng Qu,Paul Schnier,Roger Zanon et al.
Yusheng Qu et al.
Introduction: Measurement of drug-induced inhibition of potassium current flow through the hERG channel is used to determine potency at the channel, which is used as an in vitro risk assessment for QTc interval prolongati...
A simple and inexpensive method to fabricate a cannula system for intracranial injections in rats and mice [0.03%]
一种制造可用于大鼠和小鼠脑内输注的导管系统的简单且低成本的方法
Dadasaheb M Kokare,Gajanan P Shelkar,Chandrashekhar D Borkar et al.
Dadasaheb M Kokare et al.
Introduction: Stereotaxic administration of neuroactive agents, either in ventricles, or targeted at specific intracranial sites, is a widely employed strategy for neurological studies in rodents. Surgical implantation of...
S D Keir,D Spina,G Douglas et al.
S D Keir et al.
Background: Animal models of allergy and bronchial hyperresponsiveness (BHR) are useful in researching pulmonary diseases and evaluating drug effects on the airways. Neonatally immunised rabbits exhibit several features o...
Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography [0.03%]
肾上腺素调节的心肺血流量的X线数字减影血管造影测量值
MingDe Lin,Yi Qi,Antonia F Chen et al.
MingDe Lin et al.
Introduction: Cardiopulmonary blood flow is an important indicator of organ function. Limitations in measuring blood flow in live rodents suggest that rapid physiological changes may be overlooked. For instance, relative ...
U Iyer,V J Kadambi
U Iyer
Antibody drug conjugates (ADCs) consist of an antibody attached to a cytotoxic drug by means of a linker. ADCs provide a way to couple the specificity of a monoclonal antibody (mAb) to the cytotoxicity of a small-molecule drug and, therefor...
A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers [0.03%]
一种双抗原桥接免疫反应ELISA法检测聚乙二醇聚合物抗体
Yijuan Liu,Helen Reidler,Jing Pan et al.
Yijuan Liu et al.
Introduction: Polyethylene glycol (PEG) polymers attached to biotherapeutic molecules enhance in vivo delivery and stability of these large molecular weight drugs. However, these polymers may by themselves be immunogenic ...