Novel approach for generation of low calcium reagents for investigations of heavy metal effects on calcium signaling [0.03%]
一种研究重金属对钙信号影响的低钙试剂的新制备方法
Katelyn Y Niu,Nathaniel C Noyes,Thomas W Abrams
Katelyn Y Niu
Introduction: Lead exposure can cause learning disabilities, memory loss and severe damage to the nervous system. However, the exact mechanism by which lead causes learning disabilities is not fully understood. The effect...
In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer [0.03%]
基于非放射性示踪剂的大鼠组胺H₃受体拮抗剂在体受体occupancy试验研究
Ramakrishna Nirogi,Vishwottam Kandikere,Gopinadh Bhyrapuneni et al.
Ramakrishna Nirogi et al.
Introduction: Rapid and reliable preclinical receptor occupancy measurement at the target organ in relevant species is critical in accelerating the drug hunting process. The aim of this study was to develop in vivo recept...
Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: importance of the choice of species, type of cardiac tissue and perfusion time [0.03%]
三氧化二砷对分离心脏组织动作电位的直接影响：物种、心肌类型和灌注时间的选择很重要
Hua Rong Lu,Eddy Vlaminckx,Frank Cools et al.
Hua Rong Lu et al.
Introduction: The aim of the present study was to evaluate direct/acute effects of arsenic trioxide on action potentials (APs) in isolated cardiac tissues, and to investigate if the choice of species and tissue and the du...
Improvement in ARDS experimental model installation: low mortality rate and maintenance of hemodynamic stability [0.03%]
ARDS实验模型安装的改进：低死亡率和维持血流动力学稳定性
Luciana Branco Haddad,Roberta Munhoz Manzano,Felipe de Souza Rossi et al.
Luciana Branco Haddad et al.
Introduction: Many experimental models using lung lavage have been developed for the study of acute respiratory distress syndrome (ARDS). The original technique has been modified by many authors, resulting in difficulties...
Validation of a Gyrolab™ assay for quantification of rituximab in human serum [0.03%]
人血清中利妥昔单抗定量的Gyrolab™检测方法验证
Xiaodong F Liu,Xun Wang,Roni J Weaver et al.
Xiaodong F Liu et al.
Introduction: Gyrolab™ technology presents a technology breakthrough for large molecule bioanalysis to support biologic drug development. The advantages of this innovative platform include fully automated nanoscale immun...
Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers [0.03%]
P-糖蛋白药物相互作用的确定：重组P-糖蛋白在脂质体系统和LLC-MDR1极化细胞单层中的评价
Donald L Melchior,Frances J Sharom,Raymond Evers et al.
Donald L Melchior et al.
Introduction: P-Glycoprotein (ABCB1, MDR1) is a multidrug efflux pump that is a member of the ATP-binding cassette (ABC) superfamily. Many drugs in common clinical use are either substrates or inhibitors of this transport...
Evaluation of bioimpedance spectroscopy for the measurement of body fluid compartment volumes in rats [0.03%]
大鼠生物阻抗谱法测量体液容量评估
Lufei Hu,Tom Maslanik,Mykolai Zerebeckyj et al.
Lufei Hu et al.
Introduction: Bioimpedance spectroscopy (BIS) has been used in human and large animal research to assess body fluid compartment volumes (BFC) such as total body water (TBW), extracellular fluid volume (ECFV), and intracel...
Robert L Hamlin,Carlos del Rio
Robert L Hamlin
dP/dt(max) is the maximal rate of rise of (usually) left ventricular pressure (LVP), but it is determined by myocardial contractility and the loading conditions on the ventricle, thus it is an imperfect and sometimes incorrect predictor of ...
Coupled intracerebral microdialysis and electrophysiology for the assessment of dopamine neuron function in vivo [0.03%]
体内多巴胺神经元功能的脑内微透析和电生理联合检测方法
Francesca Panin,Adeline Cathala,Pier Vincenzo Piazza et al.
Francesca Panin et al.
Introduction: The central dopaminergic system is involved in the pathophysiology of several neuropsychiatric disorders. Intracerebral microdialysis and electrophysiology provide two powerful techniques to investigate dopa...