A simple accurate method for concentration-QTc analysis in preclinical animal models [0.03%]
临床前动物模型中简单精确的浓度-QTc分析方法
Kamila J Sadko,Derek J Leishman,Marc B Bailie et al.
Kamila J Sadko et al.
Introduction: In preclinical cardiovascular safety pharmacology studies, statistical analysis of the rate corrected QT interval (QTc) is the focus for predicting QTc interval changes in the clinic. Modeling of a concentra...
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments [0.03%]
characterization of ascending dose canine telemetry model supports its use in e14/s7b qt integrated risk assessments
Alysia A Chaves,Jude W Ferraro,Jing Yu et al.
Alysia A Chaves et al.
Introduction: Nonclinical evaluation of the cardiovascular effects of novel chemical or biological entities (NCE, NBEs) is crucial for supporting first-in-human clinical trials. One important aspect of these evaluations i...
Haruki Kai,Noriaki Haraoka,Yukio Sugimoto
Haruki Kai
Allergic conjunctival disease is an immune-mediated inflammatory disease of the conjunctiva. To develop clinically useful drugs, it is necessary to develop quantitative evaluation methods that reflect the clinical symptoms in experimental a...
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profiling [0.03%]
鼻内给药包载藤壳素的脂质-聚合物纳米囊的脑组织和脑脊液中藤黄素分析方法的研究及动力学分布研究
Sagar Trivedi,Rishabh Agade,Veena Belgamwar
Sagar Trivedi
Thymoquinone (TH) has been one of the major phytochemical used in the treatment of cancers since long time, especially in the management of glioblastoma multiforme (GBM). The formulation of lipo-polymeric nanoshells (LPNs) and their nasal d...
The rat telemetry assay and venous catheter access buttons for use in cardiovascular safety pharmacology assessments - Surgical methods, refinements and colony maintenance [0.03%]
心血管安全药理学评估中使用的 rat telemetry 植入术和静脉输液港的外科手术方法、改进及种群维护
Ed Hale,Diane Storer,Nastarsia Smith et al.
Ed Hale et al.
Introduction: Rat telemetry is the assay of choice to assess the potential effects of novel drug candidates on cardiovascular parameters during early drug discovery. Telemetry device implantation can be combined with veno...
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry [0.03%]
抗精神病药多巴胺2型、组胺1型和毒蕈碱型乙酰胆碱受体占有率同时测定法的建立与评价液相色谱-串联质谱法
Gaku Akashita,Eriko Nakatani,Shimako Tanaka et al.
Gaku Akashita et al.
Receptor occupancy is an indicator of antipsychotic efficacy and safety. It is desirable to simultaneously determine the occupancy of multiple brain receptors as an indicator of the efficacy and central side effects of antipsychotics becaus...
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment [0.03%]
改善体内QTc评估：非临床浓度-QTc建模以进行风险评估
Todd A Wisialowski,Nick Ether,C Michael Foley et al.
Todd A Wisialowski et al.
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6 [0.03%]
一种基于遗传算法的预测代谢型药物相互作用的方法(CYP2C8或CYP2B6)
Veronica Di Paolo,Francesco Maria Ferrari,Davide Veronese et al.
Veronica Di Paolo et al.
Background and objectives: A genetic algorithm (GA) approach was developed to predict drug-drug interactions (DDIs) caused by cytochrome P450 2C8 (CYP2C8) inhibition or cytochrome P450 2B6 (CYP2B6) inhibition or induction...
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions [0.03%]
WHO-Uppsala监测中心系统与Naranjo算法评定药物不良反应因果关系的一致性分析
Sapna A More,Shubham Atal,Pooja S Mishra
Sapna A More
Determining the causality of Adverse Drug Reactions (ADRs) is essential for management and prevention of future occurrences. The WHO-Uppsala Monitoring Centre (UMC) system is recommended under the Pharmacovigilance Program of India whereas ...
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in rats plasma using GC-MS / MS [0.03%]
采用GC-MS/MS法测定AMB-FUBINACA在大鼠血浆中的药动学参数( t1/2 、Vss 、CL )
Elkhatim Hassan Abdelgadir,Sarah Dafer Alshehri,Sachil Kumar
Elkhatim Hassan Abdelgadir
Background: Several novel synthetic cannabinoids, including methyl 2-(1-(4-fluorobenzyl)-1Hindazole-3-carboxamido)-3-methylbutanoate (AMB-FUBINACA), have recently surfaced on the illicit drug market. To determine the phar...