Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity [0.03%]
起始物种和微粒体诱导方式对卡马西平所致细胞毒性的影响
Abdelbaset A Elzagallaai,Awatif M Abuzgaia,Michael J Rieder
Abdelbaset A Elzagallaai
Standardization and validation of in vitro drug metabolism is essential for pre-clinical drug development as well as for in vitro toxicity assays including the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (iPTA)....
Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study [0.03%]
表皮葡萄球菌诱导无毛小鼠模型痤疮样皮损的比较研究
George Ladopoulos,Christina Barda,Konstantina Tsami et al.
George Ladopoulos et al.
Acne vulgaris, a chronic inflammatory skin disease with a high prevalence worldwide, necessitates reliable preclinical models for both understanding its pathogenesis and evaluating potential anti-acne therapies. This study aims to establish...
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations [0.03%]
在成本上涨和监管变化的背景下最大化非临床安全性研究的见解
Donald Hodges,Michael Stonerook,Dany Salvail et al.
Donald Hodges et al.
The traditional paradigm of non-rodent safety assessment studies, primarily reliant on non-human primates (NHPs) and dogs, is undergoing a transformation. During the 2023 Safety Pharmacology Society Annual Meeting, scientists from leading n...
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis [0.03%]
回顾性分析非啮齿类动物毒理学研究中心电图和血压记录方法的比较
Emma Pawluk,Annie Delaunois,Bastien Gamboa et al.
Emma Pawluk et al.
Our study retrospectively examines 51 non-rodent general toxicology studies conducted over the past 8 years to ascertain the influence of recording methodologies on baseline cardiovascular (CV) parameters and statistical sensitivity. Specif...
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods [0.03%]
超滤法和沉淀法测定人血浆中未结合铂的浓度
Xia Wen,Cathleen Doherty,Lauren E Thompson et al.
Xia Wen et al.
Quantification of the unbound portion of platinum (Pt) in human plasma is important for assessing the pharmacokinetics of the chemotherapeutic drug cisplatin. In this study, we sought to compare the recovery of unbound Pt using Nanosep® fi...
Cyprian Świętaszczyk,Lars Jødal
Cyprian Świętaszczyk
First-order compartment models are common tools for modelling many biological processes, including pharmacokinetics. Given the compartments and the transfer rates, solutions for the time-dependent quantity (or concentration) curves can norm...
Michael K Pugsley,Brett R Winters,Yevgeniya E Koshman et al.
Michael K Pugsley et al.
This editorial prefaces the annual themed issue on safety pharmacology (SP) methods which has been published since 2004 in the Journal of Pharmacological and Toxicological Methods (JPTM). Here we highlight content derived from the 2023 Safe...
Contractility assessment using aligned human iPSC-derived cardiomyocytes [0.03%]
使用定向排列的人类iPSC源心肌细胞进行收缩力评估
Ayano Satsuka,Alexandre J S Ribeiro,Hiroyuki Kawagishi et al.
Ayano Satsuka et al.
Introduction: Cardiac safety assessment, such as lethal arrhythmias and contractility dysfunction, is critical during drug development. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been show...
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development [0.03%]
靶向G蛋白偶联受体和离子通道的化合物对房室诱导多能干细胞心肌细胞收缩作用的腔体特异性反应：心脏药物开发的微生理系统
Bettina Lickiss,Jan Hunker,Jamie Bhagwan et al.
Bettina Lickiss et al.
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) have found utility for conducting in vitro drug screening and disease modelling to gain crucial insights into pharmacology or disease phenotype. However, diseases such...
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions [0.03%]
支持使用三个阳性对照药物的hERG余量分布（多个实验室和多次实验所得）进行整合QTc风险评估
Derek J Leishman,Jessica Brimecombe,William Crumb et al.
Derek J Leishman et al.
Background: Determination of a drug's potency in blocking the hERG channel is an established safety pharmacology study. Best practice guidelines have been published for reliable assessment of hERG potency. In addition, a ...