Roy Forster
Roy Forster
During the development of a new vaccine, the purpose of nonclinical studies is to provide safety information to support the clinical development and licensure of the product. In this article the study designs currently accepted for the nonc...
Quickly finding a needle in a haystack: a new automated cardiac arrhythmia detection software for preclinical studies [0.03%]
快速找到针：一种新的用于临床前研究的心律失常自动检测软件
Florence Koeppel,David Labarre,Philippe Zitoun
Florence Koeppel
Introduction: The occurrence of drug-induced arrhythmias in safety pharmacology or toxicology studies is a primary safety concern. The risk assessment requires an accurate knowledge of background arrhythmia incidence and ...
Evaluation of a method to correct the contractility index LVdP/dt(max) for changes in heart rate [0.03%]
评估校正心率变化的收缩力指数LVdp/dtmax的方法的效果
Michael Markert,Thomas Trautmann,Marcus Groß et al.
Michael Markert et al.
Introduction: In order to differentiate heart rate (HR)-induced changes from drug-induced positive or negative inotropic effects, HR-dependent effects need to be taken into account. Left ventricular (LV)dP/dt(max), the ma...
Rat thalamic α₄β₂ neuronal nicotinic acetylcholine receptor occupancy assay using LC-MS/MS [0.03%]
大鼠丘脑α₄β₂型烟碱乙酰胆碱受体 occupacy检测的LC-MS/MS分析方法
Ramakrishna Nirogi,Vishwottam Kandikere,Gopinadh Bhyrapuneni et al.
Ramakrishna Nirogi et al.
Introduction: In vivo brain receptor occupancy has been the key assay in driving preclinical drug discovery program and there is a need to hasten this screening step. Radiolabeled methods, which are time consuming and exp...
Comparison of non-invasive and implanted telemetric measurement of blood pressure and electrocardiogram in conscious beagle dogs [0.03%]
比较清醒比格犬无创与植入式遥测法血压及心电图测量结果
Gemma Ward,Phil Milliken,Bela Patel et al.
Gemma Ward et al.
Introduction: The objective of this study was to evaluate the ability of a non-invasive telemetry monitoring system to detect and quantify changes in blood pressure and electrocardiogram (ECG) parameters in response to ve...
Muscle on a chip: in vitro contractility assays for smooth and striated muscle [0.03%]
肌肉芯片：平滑肌和横纹肌体外收缩检测方法
Anna Grosberg,Alexander P Nesmith,Josue A Goss et al.
Anna Grosberg et al.
Introduction: To evaluate the viability of a muscle tissue, it is essential to measure the tissue's contractile performance as well as to control its structure. Accurate contractility data can aid in development of more e...
Jennifer L Ingram-Ross,Aidan K Curran,Mutsumi Miyamoto et al.
Jennifer L Ingram-Ross et al.
Introduction: This study was designed to provide a comprehensive nonclinical respiratory safety pharmacology assessment using respiratory inductance plethysmography (RIP) concomitant with a standard cardiovascular (CV) sa...
Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig [0.03%]
麻醉 Guinea Pig 中药物诱发的尖端扭转性室速需要负电机械分离模型
P-J Guns,D M Johnson,E Weltens et al.
P-J Guns et al.
Introduction: Assessment of the propensity of novel drugs to cause proarrhythmia is essential in the drug development process. It is increasingly recognized, however, that QT prolongation alone is an imperfect surrogate m...
How do the top 12 pharmaceutical companies operate safety pharmacology? [0.03%]
排名前十二的药企是如何运作安全药理学的？
Lorna Ewart,David J Gallacher,Gary Gintant et al.
Lorna Ewart et al.
Introduction: How does safety pharmacology operate in large pharmaceutical companies today? By understanding our current position, can we prepare safety pharmacology to successfully navigate the complex process of drug di...
Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis [0.03%]
外源性谷胱甘肽在采用自由基溶血法测定抗氧化能力时必不可少
Nitya Jani,James Ziogas,James A Angus et al.
Nitya Jani et al.
Introduction: Radical-induced haemolysis has been employed by many investigators to determine the antioxidant capacity of novel compounds. However the free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride ...