Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs [0.03%]
优化麻醉 Guinea Pig 急性给药对心脏收缩力指标及血液动力学影响的研究条件
Laura Mooney,Louise Marks,Karen L Philp et al.
Laura Mooney et al.
Introduction: Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the ...
Is the current product safety assessment paradigm protective for epigenetic mechanisms? [0.03%]
现行的产品安全评估范例能够保护表观遗传机制吗？
Rebecca A Alyea,Nigel P Moore,Matthew J LeBaron et al.
Rebecca A Alyea et al.
Introduction: The emerging field of epigenetics has revealed a new layer of gene regulation that is only now being fully explored. Concomitant with the increase in our understanding of epigenetic regulation are questions ...
Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin [0.03%]
一种新型无溶剂凝胶基质提取物普马革-泽兰锦葵素，用于改善プラムビン的治疗效果的方法
Chellampillai Bothiraja,Atmaram P Pawar,Ganesh Y Dama et al.
Chellampillai Bothiraja et al.
Introduction: Various shortcomings of the available methods of extraction of plumbagin from Plumbago zeylanica using non-edible organic solvents coupled with the poor aqueous solubility and low bioavailability called for ...
In vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detection [0.03%]
高效液相色谱-光电二极管阵列检测法联合液相萃取技术用于评价大鼠肝微粒体细胞色素P450酶3A4体外活性
Tarek Baati,Patricia Horcajada,Ruxandra Gref et al.
Tarek Baati et al.
Introduction: CYP3A4 is one of the most important of all drug-metabolizing enzymes. Although several direct or indirect quantification methods have been proposed for the determination of the CYP3A4 activity, the sample pr...
M K Pugsley,M J Curtis
M K Pugsley
Almost uniquely in pharmacology, drug safety assessment is driven by the need for elaboration and validation of methods for detecting drug actions. This is the 9th consecutive year that the Journal of Pharmacological and Toxicological Metho...
Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period [0.03%]
恒河猴6个月遥测心律失常的全面分析
Ray W Chui,Katayoun Derakhchan,Hugo M Vargas
Ray W Chui
Introduction: Cardiac arrhythmia findings can be a challenge to interpret and difficult to attribute to background incidence or test article treatment. Thus, there is a growing need to better understand arrhythmia inciden...
Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain [0.03%]
非放射性甲基列卡康尼丁配体在活体脑内α7神经型烟碱乙酰胆碱受体定位及分布研究
Ramakrishna Nirogi,Vishwottam Kandikere,Gopinadh Bhyrapuneni et al.
Ramakrishna Nirogi et al.
Introduction: Reduction of cerebral cortical and hippocampal α7 neuronal nicotinic acetylcholine receptor (nAChR) density was observed in the Alzheimer's disease (AD) and other neurodegenerative diseases. Mapping the sub...
Safety immunopharmacology: evaluation of the adverse potential of pharmaceuticals on the immune system [0.03%]
药物对免疫系统的不良影响的免疫药理学评价
Jacques Descotes
Jacques Descotes
The ICH S6R1 and S8 guidelines define a general framework for the immunotoxicity evaluation of biotechnology-derived pharmaceuticals and human pharmaceuticals, respectively. As severe and unpredicted adverse events dramatically showed in th...
Comparison of manual and automated filaments for evaluation of neuropathic pain behavior in rats [0.03%]
手动和自动化定量大鼠神经病理性疼痛行为的比较研究
Ramakrishna Nirogi,Venkatesh Goura,Dhanalakshmi Shanmuganathan et al.
Ramakrishna Nirogi et al.
Introduction: The most commonly used Von Frey filaments are productive in evaluating behavioral responses of neuropathic pain in preclinical and clinical research. To reduce the potential experimenter bias, automated inst...
Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass spectrometry [0.03%]
微透析联合超高压液相色谱-串联质谱法同时检测脑外渗入液中海洛因及其代谢产物
A Gottas,E L Oiestad,F Boix et al.
A Gottas et al.
Introduction: The pharmacokinetic profile and systemic bioavailability of a substance is often described by blood or total tissue concentrations. For centrally acting drugs, like opioids, the free fraction of active compo...