Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods [0.03%]
超滤法和沉淀法测定人血浆中未结合铂的浓度
Xia Wen,Cathleen Doherty,Lauren E Thompson et al.
Xia Wen et al.
Quantification of the unbound portion of platinum (Pt) in human plasma is important for assessing the pharmacokinetics of the chemotherapeutic drug cisplatin. In this study, we sought to compare the recovery of unbound Pt using Nanosep® fi...
Cyprian Świętaszczyk,Lars Jødal
Cyprian Świętaszczyk
First-order compartment models are common tools for modelling many biological processes, including pharmacokinetics. Given the compartments and the transfer rates, solutions for the time-dependent quantity (or concentration) curves can norm...
Michael K Pugsley,Brett R Winters,Yevgeniya E Koshman et al.
Michael K Pugsley et al.
This editorial prefaces the annual themed issue on safety pharmacology (SP) methods which has been published since 2004 in the Journal of Pharmacological and Toxicological Methods (JPTM). Here we highlight content derived from the 2023 Safe...
Contractility assessment using aligned human iPSC-derived cardiomyocytes [0.03%]
使用定向排列的人类iPSC源心肌细胞进行收缩力评估
Ayano Satsuka,Alexandre J S Ribeiro,Hiroyuki Kawagishi et al.
Ayano Satsuka et al.
Introduction: Cardiac safety assessment, such as lethal arrhythmias and contractility dysfunction, is critical during drug development. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been show...
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development [0.03%]
靶向G蛋白偶联受体和离子通道的化合物对房室诱导多能干细胞心肌细胞收缩作用的腔体特异性反应：心脏药物开发的微生理系统
Bettina Lickiss,Jan Hunker,Jamie Bhagwan et al.
Bettina Lickiss et al.
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) have found utility for conducting in vitro drug screening and disease modelling to gain crucial insights into pharmacology or disease phenotype. However, diseases such...
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions [0.03%]
支持使用三个阳性对照药物的hERG余量分布（多个实验室和多次实验所得）进行整合QTc风险评估
Derek J Leishman,Jessica Brimecombe,William Crumb et al.
Derek J Leishman et al.
Background: Determination of a drug's potency in blocking the hERG channel is an established safety pharmacology study. Best practice guidelines have been published for reliable assessment of hERG potency. In addition, a ...
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities [0.03%]
贝叶斯方法实现多个诱导多能干细胞分化心肌细胞(proarrhythmia敏感性)的客观比较
Tetsuro Wakatsuki,Neil Daily,Sunao Hisada et al.
Tetsuro Wakatsuki et al.
The one-size-fits-all approach has been the mainstream in medicine, and the well-defined standards support the development of safe and effective therapies for many years. Advancing technologies, however, enabled precision medicine to treat ...
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva [0.03%]
苯基硫脲介导的实验性脱色可降低斑马鱼幼体中戊四唑的惊厥反应
Savita Kumari,Damanpreet Singh
Savita Kumari
Zebrafish larvae exposed to chemoconvulsants show behavioral seizures and electrographic abnormalities similar to the other mammalian models, making it a potential tool in epilepsy research. During the embryonic stage, zebrafish remains tra...
Optimization of an in vitro method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells [0.03%]
一种用于评估吸入性药物肺渗透性的体外方法的优化：使用肺泡上皮细胞法
Nitesh Shirsath,Rohit Chaudhari,Avinash More et al.
Nitesh Shirsath et al.
Introduction: Inhalation of drugs for the treatment of pulmonary diseases has been used since a long time. Due to lungs' larger absorptive surface area, delivery of drugs to the lungs is the method of choice for different...
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone [0.03%]
莫西沙星和胺碘酮给药对非临床种属J点至T峰值及T峰值至T波终点间期优化测量的影响
Theresa M Bartko,Stephen M Lutgen,Rebecca A Ross et al.
Theresa M Bartko et al.
Introduction: Cardiovascular safety and the risk of developing the potentially fatal ventricular tachyarrhythmia, Torsades de Pointes (TdP), have long been major concerns of drug development. TdP is associated with a dela...