Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction [0.03%]
基于动脉血压数据对心脏收缩力变化的对称投影吸引子重构检测法
Esther Bonet-Luz,Manasi Nandi,Mark I Christie et al.
Esther Bonet-Luz et al.
The potential for unintended drug induced changes in cardiac contractility is a major concern in medicines development. Whilst direct left ventricular pressure (LVP) measurement is the gold standard for measuring cardiac contractility in vi...
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits [0.03%]
帕克利替尼定量的LC-MS-MS方法的发展与验证；兔子中的动力学应用研究
Phani Kumar Sunkara,Sreedhara Chaganty,K Ramakrishna
Phani Kumar Sunkara
Background: Accurate and selective LC/ESI-MSMS method development and validation for the quantitation of pacritinib is the primary goal of this study to perform kinetic studies in the healthy rabbit. ...
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited [0.03%]
5-羟色胺2B受体激动剂相关心脏瓣膜病的临床前防治方法再探讨
Bérengère M Dumotier,Laszlo Urban
Bérengère M Dumotier
Cardiac valvulopathy (Cardiac Valve Disease; CVD) associated with off-target activation of the 5-hydroxytryptamine (5-HT) 2B receptor has been well recognized, but is still poorly predicted during drug development. The regulatory guidance p...
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium [0.03%]
评估校正后的JT峰(JTpc)和T波峰间期(TpTec)在非人灵长类动物中作为致心律失常生物标志物的效果：HESI联盟的结果
Emmanuel Boulay,Simon Authier,Theresa Bartko et al.
Emmanuel Boulay et al.
Introduction: Corrected QT interval (QTc)is an established biomarker for drug-induced Torsade de Pointe (TdP), but with concerns for a false positive signal. Clinically, JTpc and TpTec have emerged as ECG sub-intervals to...
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay [0.03%]
一种新型人重组肝细胞生长因子E3112在大鼠和猴体内的非临床药代动力学研究（使用简易ELISA试剂盒）
Muneo Aoyama,Yuji Mano
Muneo Aoyama
E3112 is a recombinant human hepatocyte growth factor which is under development for the treatment of acute liver failure. Pharmacokinetics (PK) evaluation in experimental animals is important and thus a simple assay for the determination o...
Ultra-fast UPLC-MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis [0.03%]
一种超快速UPLC-MS/MS法测定人类肝微粒体中X-376的方法：通过计算机软件和体外实验评估其代谢稳定性
Mohamed W Attwa,Ali S Abdelhameed,Adnan A Kadi
Mohamed W Attwa
X-376 is a novel anaplastic lymphoma kinase (ALK) inhibitor that is capable of penetrating the blood brain barrier. This makes it suitable for use in patients with ALK-positive non-small cell lung cancer (NSCLC) who have metastases in the c...
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity [0.03%]
起始物种和微粒体诱导方式对卡马西平所致细胞毒性的影响
Abdelbaset A Elzagallaai,Awatif M Abuzgaia,Michael J Rieder
Abdelbaset A Elzagallaai
Standardization and validation of in vitro drug metabolism is essential for pre-clinical drug development as well as for in vitro toxicity assays including the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (iPTA)....
Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study [0.03%]
表皮葡萄球菌诱导无毛小鼠模型痤疮样皮损的比较研究
George Ladopoulos,Christina Barda,Konstantina Tsami et al.
George Ladopoulos et al.
Acne vulgaris, a chronic inflammatory skin disease with a high prevalence worldwide, necessitates reliable preclinical models for both understanding its pathogenesis and evaluating potential anti-acne therapies. This study aims to establish...
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations [0.03%]
在成本上涨和监管变化的背景下最大化非临床安全性研究的见解
Donald Hodges,Michael Stonerook,Dany Salvail et al.
Donald Hodges et al.
The traditional paradigm of non-rodent safety assessment studies, primarily reliant on non-human primates (NHPs) and dogs, is undergoing a transformation. During the 2023 Safety Pharmacology Society Annual Meeting, scientists from leading n...
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis [0.03%]
回顾性分析非啮齿类动物毒理学研究中心电图和血压记录方法的比较
Emma Pawluk,Annie Delaunois,Bastien Gamboa et al.
Emma Pawluk et al.
Our study retrospectively examines 51 non-rodent general toxicology studies conducted over the past 8 years to ascertain the influence of recording methodologies on baseline cardiovascular (CV) parameters and statistical sensitivity. Specif...