Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™ [0.03%]
基于Secondary Intelligence的脱靶受体相互作用预测临床结局
Will S Redfern,Chris E Pollard,Mark Holbrook et al.
Will S Redfern et al.
Adverse effects due to off-target activity can be predicted by careful comparison of the relationship between expected plasma concentration and off-target activity of the test compound with that of reference drugs targeting that receptor fo...
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide) [0.03%]
生物碱/盐(尼古丁、烟碱苯甲酸盐、咖啡因和槟榔子碱氢溴酸盐)激发差异的分子影像学研究
Dawei Yan,Xiaomin Liu,Yihan Gao et al.
Dawei Yan et al.
Comparison of the excitability of four different alkaloids/salts, including nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide. Based on positron emission tomography (PET) imaging and 18F-Fallypride, a novel technique for mea...
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration [0.03%]
原位多草本凝胶作为阿尔茨海默病的生物医学管理手段：了解三甲基锡诱导神经退行性病变的改善潜力
Sneha Latha Diddi,Sathiyanarayanan Lohidasan,Arulmozhi S et al.
Sneha Latha Diddi et al.
Alzheimer's disease (AD), classified as neurodegenerative disorder that progresses over a period of time, is characterized by intracellular neurofibrillary tangles and extracellular amyloid plaques. This present research work was designed t...
Evaluation of 4 quantification methods for monitoring 16 antidepressant drugs and their metabolites in human plasma by LC-MS/MS [0.03%]
四种方法评价液相色谱-串联质谱法测定人血浆中16种抗抑郁药物及其代谢产物的方法学考核
Lingjiao Wang,Mengqiang Zhao,Jiao Li et al.
Lingjiao Wang et al.
Background: Therapeutic drug monitoring for antidepressants (ADs) is vital due to the potentially serious consequences and disputes related to medical events. Therefore, we created a quick and convenient analysis way for ...
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel [0.03%]
延迟起效药物在血清无细胞培养条件下致心律失常风险的评估；脱脂诱导probucol对KCNQ1+KCNE1电流作用加快/加强
Kenny M Van Theemsche,Lisse Frans,Dieter V Van de Sande et al.
Kenny M Van Theemsche et al.
In vitro testing procedures for evaluating acute effects of compound on ion channels, utilizing heterologous expression systems (HES), are well-established, while slowly manifesting delayed effects remain challenging to detect. For this, im...
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms [0.03%]
选择性纳米颗粒的比较毒性评估的不同实验模型生物体中
Srishti Parashar,Sheetal Raj,Priyanka Srivastava et al.
Srishti Parashar et al.
Nanoparticles are microscopic particles ranging in size from one to one hundred nanometers. Due to their extensive features, nanoparticles find widespread use in various fields worldwide, including cosmetics, medical diagnosis, pharmaceutic...
Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA initiative [0.03%]
维拉帕米在生理温度下对hERG钾通道的抑制作用以及其对CiPA计划的意义
Ashley A Johnson,Matthew C Trudeau
Ashley A Johnson
The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative reassesses using the inhibition of hERG potassium channels by drugs as the major determinant for the potential to cause drug-induced Torsades de Pointes (TdP) cardiac arrhythm...
Assessment of antiemetic activity of dihydrocoumarin: In vivo and in silico approaches on receptor binding affinity and modulatory effects [0.03%]
评估二氢香豆素的止吐活性：受体结合亲和力及调节作用的体内与体外研究
Md Abu Saim,Md Shimul Bhuia,Tanzila Akter Eity et al.
Md Abu Saim et al.
Dihydrocoumarin (DCN) is a natural compound widely used in the flavor industry and has antioxidant and anti-inflammatory properties. However, its potential antiemetic effects on gastrointestinal disturbances remain untested. This study emph...
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system [0.03%]
克服三维细胞培养模型建立中的障碍：使用临床定位仪系统培养A549非小细胞肺癌类球体的方法
Charity M Mabela,Chrisna Gouws,Wihan Pheiffer
Charity M Mabela
Introduction: Non-small cell lung cancer (NSCLC) accounts for 80-85 % of lung cancer cases globally. And the A549 cell line is widely used in pharmacological and toxicity screening. Due to its popularity as a NSCLC model,...
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients [0.03%]
一种用于侵袭性曲霉病患者体内伏立康唑、泊沙康唑、氟康唑、伊曲康唑和羟基伊曲康唑的同时测定的通用快速LC-MS/MS方法
Wenwen Xia,Shun Chen,Yunlei Yun et al.
Wenwen Xia et al.
Objective: To establish a rapid and universal quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) method for measuring the exposure levels of five triazole antifungal drugs in human plasma, including vo...