Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate, and paracetamol [0.03%]
化学计量学辅助分光光度法同时测定盐酸苯乙明、马来酸氯苯那敏和对乙酰氨基酚
Muhammad W Sabr,Diyar S Ali,Slim Smaoui et al.
Muhammad W Sabr et al.
This study presents an eco-friendly, combined UV spectrophotometric method based on derivative ratio and second derivative for the simultaneous determination and quantification of phenylephrine HCl (PHE), chlorpheniramine maleate (CPM), and...
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys [0.03%]
心血管遥测设备的外科器械对 cynomolgus猴的一般毒理学数据解释影响最小
Xiefan Fang,Jui-Tung Ray Liu,Stephen D Tichenor
Xiefan Fang
Increasing numbers of general toxicology studies with integrated implanted cardiovascular (CV) telemetry are being conducted due to the constrained supply of nonhuman primates and demands for higher method sensitivities as per ICH S7B Q&A. ...
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat [0.03%]
贝叶斯预测方法在研究性别和高脂饮食对大鼠罗哌卡因药代动力学影响中的应用
Shamima Parvin,Hamdah M Al Nebaihi,John R Ussher et al.
Shamima Parvin et al.
Bayesian forecasting is commonly applied as part of therapeutic drug monitoring to obtain individual estimates of pharmacokinetic parameters in patients. Here its utility was explored in a preclinical study involving ropivacaine, in which s...
Intra-laboratory validation of yeast-based reporter gene assays for human thyroid hormone receptors [0.03%]
基于酵母的报道基因检测在人甲状腺激素受体研究中的室内验证
Masahiro Ogawa,Junya Kitamoto,Mayuko Nakashima et al.
Masahiro Ogawa et al.
Thyroid hormones (THs) function by activating TH receptors (THRα and THRβ) on the target cells. Several chemicals adversely affect human health and ecosystems by disrupting TH signaling. Multiple assays for thyroid disruption have been re...
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods [0.03%]
利用生物信息学方法识别与异氟醚麻醉和神经认知障碍相关的基因表达变化
Yang Liu,Ying Zhang,Jialu Yu et al.
Yang Liu et al.
Background: Isoflurane, a commonly used anesthetic, has been linked to neurocognitive dysfunction (NCD). However, the precise relationship between isoflurane anesthesia and NCD remains unclear. ...
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease [0.03%]
一种测定人类血浆中乌帕替尼的敏感型LC-MS/MS法及其在炎症性肠病患者中的应用开发与验证研究
M S Jingjing Wu,M D Lang Lin,M S Jia-Jia Yan et al.
M S Jingjing Wu et al.
Background: Upadacitinib is a selective Janus kinase (JAK) 1 inhibitor approved by the Food and Drug Administration for the treatment of moderate-to-severe inflammatory bowel disease (IBD). We aimed to establish and valid...
Drug combination assays using Caenorhabditis elegans as a model system [0.03%]
利用秀丽隐杆线虫作为模型体系进行药物组合筛选效应的研究
Guillermina Hernando,Cecilia Bouzat
Guillermina Hernando
The C. elegans drug combination assay evaluates the effects of drug combinations in the nematode Caenorhabditis elegans, serving as a valuable tool to assess the efficacy of pharmaceutical agents and natural compounds. Using C. elegans as a...
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study [0.03%]
用于定量检测新型抗体药物偶联物猴血清的分析方法验证及在非临床研究中的应用
Yingying Hou,Jie Miao,Yajun Sun et al.
Yingying Hou et al.
Background: Antibody-drug conjugates (ADCs) are an emerging class of targeted therapeutics and are receiving growing attention in the pharmaceutical field. Here we aimed to validate two ligand binding assays for the quant...
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach [0.03%]
基于表位工程的白喉毒素免疫毒素免疫原性折中的计算机模拟方法研究
Behrouz Golichenari,Mohammad Heiat,Ehsan Rezaei et al.
Behrouz Golichenari et al.
Immunotoxins are genetically engineered recombinant proteins consisting of a targeting moiety, such as an antibody, and a cytotoxic toxin moiety of microbial origin. Pseudomonas exotoxin A and diphtheria toxin (DT) have been abundantly used...
Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose-response in nonhuman primates [0.03%]
利用非人灵长类动物多非利特剂量-效应关系展示非临床QTc分析的统计学和药理学敏感性
Derek J Leishman,David L Holdsworth,Derek D Best et al.
Derek J Leishman et al.
Nonclinical QTc studies can augment clinical QTc assessments in regulatory submissions provided they are of sufficient quality and sensitivity. Both the statistical performance and species translation play a role in determining the sensitiv...