Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods [0.03%]
利用生物信息学方法识别与异氟醚麻醉和神经认知障碍相关的基因表达变化
Yang Liu,Ying Zhang,Jialu Yu et al.
Yang Liu et al.
Background: Isoflurane, a commonly used anesthetic, has been linked to neurocognitive dysfunction (NCD). However, the precise relationship between isoflurane anesthesia and NCD remains unclear. ...
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease [0.03%]
一种测定人类血浆中乌帕替尼的敏感型LC-MS/MS法及其在炎症性肠病患者中的应用开发与验证研究
M S Jingjing Wu,M D Lang Lin,M S Jia-Jia Yan et al.
M S Jingjing Wu et al.
Background: Upadacitinib is a selective Janus kinase (JAK) 1 inhibitor approved by the Food and Drug Administration for the treatment of moderate-to-severe inflammatory bowel disease (IBD). We aimed to establish and valid...
Drug combination assays using Caenorhabditis elegans as a model system [0.03%]
利用秀丽隐杆线虫作为模型体系进行药物组合筛选效应的研究
Guillermina Hernando,Cecilia Bouzat
Guillermina Hernando
The C. elegans drug combination assay evaluates the effects of drug combinations in the nematode Caenorhabditis elegans, serving as a valuable tool to assess the efficacy of pharmaceutical agents and natural compounds. Using C. elegans as a...
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study [0.03%]
用于定量检测新型抗体药物偶联物猴血清的分析方法验证及在非临床研究中的应用
Yingying Hou,Jie Miao,Yajun Sun et al.
Yingying Hou et al.
Background: Antibody-drug conjugates (ADCs) are an emerging class of targeted therapeutics and are receiving growing attention in the pharmaceutical field. Here we aimed to validate two ligand binding assays for the quant...
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach [0.03%]
基于表位工程的白喉毒素免疫毒素免疫原性折中的计算机模拟方法研究
Behrouz Golichenari,Mohammad Heiat,Ehsan Rezaei et al.
Behrouz Golichenari et al.
Immunotoxins are genetically engineered recombinant proteins consisting of a targeting moiety, such as an antibody, and a cytotoxic toxin moiety of microbial origin. Pseudomonas exotoxin A and diphtheria toxin (DT) have been abundantly used...
Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose-response in nonhuman primates [0.03%]
利用非人灵长类动物多非利特剂量-效应关系展示非临床QTc分析的统计学和药理学敏感性
Derek J Leishman,David L Holdsworth,Derek D Best et al.
Derek J Leishman et al.
Nonclinical QTc studies can augment clinical QTc assessments in regulatory submissions provided they are of sufficient quality and sensitivity. Both the statistical performance and species translation play a role in determining the sensitiv...
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™ [0.03%]
基于Secondary Intelligence的脱靶受体相互作用预测临床结局
Will S Redfern,Chris E Pollard,Mark Holbrook et al.
Will S Redfern et al.
Adverse effects due to off-target activity can be predicted by careful comparison of the relationship between expected plasma concentration and off-target activity of the test compound with that of reference drugs targeting that receptor fo...
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide) [0.03%]
生物碱/盐(尼古丁、烟碱苯甲酸盐、咖啡因和槟榔子碱氢溴酸盐)激发差异的分子影像学研究
Dawei Yan,Xiaomin Liu,Yihan Gao et al.
Dawei Yan et al.
Comparison of the excitability of four different alkaloids/salts, including nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide. Based on positron emission tomography (PET) imaging and 18F-Fallypride, a novel technique for mea...
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration [0.03%]
原位多草本凝胶作为阿尔茨海默病的生物医学管理手段：了解三甲基锡诱导神经退行性病变的改善潜力
Sneha Latha Diddi,Sathiyanarayanan Lohidasan,Arulmozhi S et al.
Sneha Latha Diddi et al.
Alzheimer's disease (AD), classified as neurodegenerative disorder that progresses over a period of time, is characterized by intracellular neurofibrillary tangles and extracellular amyloid plaques. This present research work was designed t...
Evaluation of 4 quantification methods for monitoring 16 antidepressant drugs and their metabolites in human plasma by LC-MS/MS [0.03%]
四种方法评价液相色谱-串联质谱法测定人血浆中16种抗抑郁药物及其代谢产物的方法学考核
Lingjiao Wang,Mengqiang Zhao,Jiao Li et al.
Lingjiao Wang et al.
Background: Therapeutic drug monitoring for antidepressants (ADs) is vital due to the potentially serious consequences and disputes related to medical events. Therefore, we created a quick and convenient analysis way for ...