Lipopolysaccharide-induced abdominal nociception model in adult zebrafish (Danio rerio) [0.03%]
腹脂多糖诱导的成年斑马鱼（丹尼罗氏斑马鱼）腹腔疼痛模型
Maria Rayane C de Oliveira,Sacha Aubrey A R Santos,Gabriela A do Nascimento et al.
Maria Rayane C de Oliveira et al.
In this study, a behavioral model of LPS-induced abdominal nociception was developed in adult zebrafish (Danio rerio), aZF. Initially, the toxicity of different LPS concentrations was assessed. The abdominal nociceptive response to the lowe...
Fast urine metabolomics for the assessment of Zopiclone effects on insomnia [0.03%]
快速尿代谢组学评估佐匹克隆对失眠的影响
Jun Li,Yang Zhao,Guifang Liu et al.
Jun Li et al.
Insomnia is a common symptom of many diseases and is closely associated with neurodegenerative diseases. Zopiclone is one of several clinical hypnotics for treating insomnia. However, some patients are sensitive to this drug treatment, wher...
Taking a deep breath: Evidence-based approaches to respiratory safety assessment [0.03%]
深吸一口气：基于证据的呼吸道安全评估方法
J J Kremer,M Bridgland-Taylor,M Clark et al.
J J Kremer et al.
Modernization of the necessity and conduct of nonclinical respiratory assays should be undertaken to enhance their translational impact for clinical outcomes, optimize animal and development costs, and ultimately strengthen regulatory relev...
Michael K Pugsley,Simon Authier,Brett R Winters et al.
Michael K Pugsley et al.
The second salary survey of safety pharmacology professionals was conducted in late 2023. This electronic survey was distributed to all members of the Safety Pharmacology Society (SPS). Survey questions assessed demographic variables, profe...
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods [0.03%]
大鼠泌尿系结石致石物质的有创与无创对比研究
S Sakthikarthikeyan,S Ramesh,P Senthilkumar et al.
S Sakthikarthikeyan et al.
Urolithiasis has been globally reported in humans and animals due to multiple factors. Research on the management and treatment of urolithiasis would benefit if suitable lithogenic agents replicate various degrees of severity as seen in hum...
The statistical and pharmacological sensitivity of nonclinical QTc analysis comparing jacketed telemetry and multilead snapshot recording in the same dogs [0.03%]
夹克式遥测与多导联快照记录在同一犬上的非临床QTc分析的统计和药理敏感性研究
Matthew M Abernathy,Derek D Best,Derek J Leishman
Matthew M Abernathy
Quantitative QTc assessment in toxicology studies can use one of two techniques, either continuous telemetry recording in ambulatory animals or short snapshots of electrocardiograms recorded using multilead electrodes in restrained animals....
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate, and paracetamol [0.03%]
化学计量学辅助分光光度法同时测定盐酸苯乙明、马来酸氯苯那敏和对乙酰氨基酚
Muhammad W Sabr,Diyar S Ali,Slim Smaoui et al.
Muhammad W Sabr et al.
This study presents an eco-friendly, combined UV spectrophotometric method based on derivative ratio and second derivative for the simultaneous determination and quantification of phenylephrine HCl (PHE), chlorpheniramine maleate (CPM), and...
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys [0.03%]
心血管遥测设备的外科器械对 cynomolgus猴的一般毒理学数据解释影响最小
Xiefan Fang,Jui-Tung Ray Liu,Stephen D Tichenor
Xiefan Fang
Increasing numbers of general toxicology studies with integrated implanted cardiovascular (CV) telemetry are being conducted due to the constrained supply of nonhuman primates and demands for higher method sensitivities as per ICH S7B Q&A. ...
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat [0.03%]
贝叶斯预测方法在研究性别和高脂饮食对大鼠罗哌卡因药代动力学影响中的应用
Shamima Parvin,Hamdah M Al Nebaihi,John R Ussher et al.
Shamima Parvin et al.
Bayesian forecasting is commonly applied as part of therapeutic drug monitoring to obtain individual estimates of pharmacokinetic parameters in patients. Here its utility was explored in a preclinical study involving ropivacaine, in which s...
Intra-laboratory validation of yeast-based reporter gene assays for human thyroid hormone receptors [0.03%]
基于酵母的报道基因检测在人甲状腺激素受体研究中的室内验证
Masahiro Ogawa,Junya Kitamoto,Mayuko Nakashima et al.
Masahiro Ogawa et al.
Thyroid hormones (THs) function by activating TH receptors (THRα and THRβ) on the target cells. Several chemicals adversely affect human health and ecosystems by disrupting TH signaling. Multiple assays for thyroid disruption have been re...