Comparison of three analytical methods for superoxide produced by activated immune cells [0.03%]
三种测定活化免疫细胞产生超氧阴离子的分析方法比较研究
Zhixiang Zhu,Ran Guo,Yunqian Li et al.
Zhixiang Zhu et al.
Superoxide plays a key role in normal immune function and inflammatory diseases. In order to evaluate normal immune function or screen inhibitors of superoxide production for treating inflammatory diseases, it is very important to detect su...
Precipitation of test chemicals in reaction solutions used in the amino acid derivative reactivity assay and the direct peptide reactivity assay [0.03%]
氨基酸衍生物反应检测试验和直接肽反应试验中试化物在反应溶液中的沉淀作用
Yusuke Yamamoto,Sayaka Wanibuchi,Ayako Sato et al.
Yusuke Yamamoto et al.
The Amino acid Derivative Reactivity Assay (ADRA) was developed by the authors as an in chemico alternative to animal testing for skin sensitization potential. Although ADRA is based on the same scientific principles as the Direct Peptide R...
A label-free approach to detect cell viability/cytotoxicity based on intracellular xanthine/guanine by electrochemical method [0.03%]
基于电化学方法的针对细胞内黄嘌呤/鸟嘌呤的无标记检测细胞存活率/细胞毒性的新方法
Wenqiang Wang,Jiwen Cui,Yanli Zhao et al.
Wenqiang Wang et al.
Introduction: Cell viability and cytotoxicity is one of the most important toxicology indicators. In this study, an electrochemical method for detecting cell viability and cytotoxicity was discussed with the intracellular...
Relationship of clinical adverse event reports to models of arrhythmia risk [0.03%]
临床不良事件报告与心律失常风险模型之间的关系
Nicholas Ether,Derek Leishman,Marc Bailie et al.
Nicholas Ether et al.
A vital aspect of the drug discovery and development process is the identification and filtering of drugs with high risk of dangerous adverse events. Torsade de Pointes (TdP) is one example of an adverse event that requires thorough in vitr...
Relationship of clinical adverse event reports to models of arrhythmia risk [0.03%]
临床不良事件报告与心律失常风险模型的关系研究
Nicholas Ether,Derek Leishman,Marc Bailie et al.
Nicholas Ether et al.
A vital aspect of the drug discovery and development process is the identification and filtering of drugs with high risk of dangerous adverse events. Torsade de Pointes (TdP) is one example of an adverse event that requires thorough in vitr...
Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates" [0.03%]
脑电图：大鼠、犬和非人灵长类动物药物诱导惊厥的特征性再版论文
Simon Authier,Joseph Arezzo,Mylène Pouliot et al.
Simon Authier et al.
Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (...
Derivation and presentation of formulas for drug concentrations in two-, three- and four-compartment pharmacokinetic models [0.03%]
二、三和四室药动学模型中药物浓度公式的推导与表示
Cyprian Świętaszczyk,Lars Jødal
Cyprian Świętaszczyk
Although compartment models are frequently used in pharmacokinetics, it is difficult to find complete analytical formulas describing the behaviour of drugs in universal simpler compartment models in the accessible literature. The paper pres...
Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms [0.03%]
基于电压敏感光学平台的诱导多能干细胞源性心肌细胞药物反应的电生理表征
Emily R Pfeiffer-Kaushik,Godfrey L Smith,Beibei Cai et al.
Emily R Pfeiffer-Kaushik et al.
Introduction: Voltage-sensitive optical (VSO) sensors offer a minimally invasive method to study the time course of repolarization of the cardiac action potential (AP). This Comprehensive in vitro Proarrhythmia Assay (CiP...
A fast paraquat quantitation method in human serum using probe electrospray ionization-tandem mass spectrometry for emergency settings [0.03%]
一种用于紧急情况下人血清中百草枯快速定量的方法：探针电喷雾离子化-串联质谱法
Kiyotaka Usui,Eriko Minami,Yuji Fujita et al.
Kiyotaka Usui et al.
Introduction: Paraquat (PQ) is one of the most toxic herbicides to humans. However, it is still in use in many countries, including Japan, and many incidents, such as homicides, intentional ingestions, and occupational ac...
Stefanie Bendels,Caterina Bissantz,Bernhard Fasching et al.
Stefanie Bendels et al.
Background: Several factors contribute to the development failure of novel pharmaceuticals, one of the most important being adverse effects in pre-clinical and clinical studies. Early identification of off-target compound...