Dynamic features of cardiac vector as alternative markers of drug-induced spatial dispersion [0.03%]
心电向量动力学作为药物诱导的室性早搏在空间上分散的替代标志物
Pablo Daniel Cruces,Drago Torkar,Pedro David Arini
Pablo Daniel Cruces
Introduction: The abnormal amplification of ventricular repolarization dispersion (VRD) has long been linked to proarrhythmia risk. Recently, the measure of VRD through electrocardiogram intervals has been strongly questi...
Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment [0.03%]
心脏安全性评估中的机械刺激与高通量收缩检测技术的结合应用研究
Matthias Goßmann,Peter Linder,Ulrich Thomas et al.
Matthias Goßmann et al.
Induction: Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models ...
Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platform [0.03%]
基于人诱导多能干细胞源心肌细胞在Biowire TM II平台的工程心脏三维组织正性变力作用评价研究
Yusheng Qu,Nicole Feric,Isabella Pallotta et al.
Yusheng Qu et al.
To develop therapeutics for cardiovascular disease, especially heart failure, translational models for assessing cardiac contractility are necessary for preclinical target validation and lead optimization. The availability of stem cell-deri...
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method [0.03%]
利用深度学习方法量化由hiPSCs衍生的肝细胞和心肌细胞中由药物诱导的结构毒性
Mahnaz Maddah,Mohammad A Mandegar,Keri Dame et al.
Mahnaz Maddah et al.
Cardiac and hepatic toxicity result from induced disruption of the functioning of cardiomyocytes and hepatocytes, respectively, which is tightly related to the organization of their subcellular structures. Cellular structure can be analyzed...
Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes [0.03%]
Actiwatch-Mini在狗的安全性研究中作为药物引起的行为变化的早期指标的使用
Frank Cools,Ivan Kopljar,Tekle Fetene et al.
Frank Cools et al.
Introduction: Clinical observations are routinely used to address drug-induced behavioural changes in dogs. To deal with the limitations of this methodology, we evaluated Actiwatch-Mini® as a tool to monitor continuously...
Characterization of an i.p. D-galactose-induced cataract model in rats [0.03%]
大鼠玻璃体内注射D-半乳糖诱导的白内障模型的特点研究
Lei Zhong,Tao Wang,Ting Wang et al.
Lei Zhong et al.
Cataracts have been identified as a main cause of global visual impairment and blindness; in addition, diabetic and aging cataracts are the most common types. The aim of this project was to develop a suitable animal model and investigate th...
Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes [0.03%]
基于视频的药物诱导作用于收缩运动属性的人类诱导多能干细胞源性心肌细胞评估方法
Yoshiko Okai,Keiko Matsune,Kazunori Yamanaka et al.
Yoshiko Okai et al.
Introduction: Drug-induced inotropic change is a risk factor in drug development; thus, de-risking is desired in the early stages of drug development. Unlike proarrhythmic risk assessment using human induced pluripotent s...
Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects [0.03%]
电压感应光学记录法：一种评估心肌活性的高通量方法
Stéphane Bedut,Ralf Kettenhofen,Jean-Marc D&#x;Angelo
Stéphane Bedut
Introduction: Voltage and calcium-sensing optical recording (VSOR and CSOR, respectively) from human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been validated for in vitro evaluation of cardiotropic effe...
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model [0.03%]
一种选择校准药物以进行实验室特异性验证和校准促心律失常风险预测模型的方法：使用CiPA模型的示例说明
Xiaomei Han,Mohammadreza Samieegohar,Bradley J Ridder et al.
Xiaomei Han et al.
Introduction: In response to the ongoing shift of the regulatory cardiac safety paradigm, a recent White Paper proposed general principles for developing and implementing proarrhythmia risk prediction models. These princi...
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology [0.03%]
INSPIRE：欧洲心血管安全药理学研究和培训网络
Pieter-Jan D Guns,Brian D Guth,Stefan Braam et al.
Pieter-Jan D Guns et al.
Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reacti...