Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy [0.03%]
由于ZDF大鼠进行性肾病和致死性肾病的存在，因此用其模拟膳食脂肪诱发的高凝状态的作用是有限的
Michael K Pugsley,Marjory B Brooks,Cindy E Fishman et al.
Michael K Pugsley et al.
Introduction: Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary fat on the development of Type 2 ...
Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice [0.03%]
通过BALB/c小鼠的主动脉缩窄诱导心力衰竭的实验模型
Shahid Tannu,John Allocco,Melissa Yarde et al.
Shahid Tannu et al.
Introduction: Murine transverse aortic constriction (TAC) is a frequently used model of pressure overload-induced left ventricular (LV) remodeling. However, there is considerable variability in disease progression to over...
Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs [0.03%]
九氢大麻醇：在雌性Lister Hooded 大鼠中进行药物区分滥用潜力测试：过程，困难和成功
S S Rowton,B A Rocha,I E Porter
S S Rowton
Introduction: The assessment of the abuse potential of CNS-active drugs is a regulatory requirement. Drug discrimination is one of the nonclinical tests that contribute to this assessment by providing information on a dru...
Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples [0.03%]
LC-MS/MS同时测定头发中的巴比妥类、苯妥英和托吡酯及在实际样品中的应用
Jihyun Kim,Junghyun Kim,Hyesun Yum et al.
Jihyun Kim et al.
Introduction: Hair analysis is useful for monitoring exposure to drugs such as antiepileptics owing to long-term therapy and a high possibility of abuse of drugs, which could be fatal. An effective and rapid analytical me...
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics [0.03%]
秀丽隐杆线虫可能作为筛选抗阿尔茨海默病药物的模型
Deepraj Paul,Sandhya Chipurupalli,Antony Justin et al.
Deepraj Paul et al.
Alzheimer's disease (AD) is regarded as one of the significant health burdens, as the prevalence is raising worldwide and gradually reaching to epidemic proportions. Consequently, a number of scientific investigations have been initiated to...
Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes [0.03%]
测定绵羊肝微粒体细胞色素P450 1A2, 2C9, 2D6和3A4活性的方法的建立
Grace M McBride,Jia Yin Soo,Tamara Varcoe et al.
Grace M McBride et al.
Introduction: Ex vivo studies of human fetal hepatic drug metabolism are uncommon as it requires access to functional liver tissue and therefore raises practical and ethical concerns. Large animal models provide an altern...
Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples [0.03%]
验证硫酸类固醇水解在代谢研究中的应用。应用于人尿样本
Dayamin Martinez-Brito,Maria Laura Notarianni,Michele Iannone et al.
Dayamin Martinez-Brito et al.
Background: Urinary sulfate fraction of the anabolic androgenic steroids is not analyzed routinely in anti-doping analyses but has demonstrated in the last years an increasing interest among the anti-doping community. Sul...
Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative [0.03%]
非临床物种对抽搐的敏感性：IQ DruSafe 联盟工作组计划
Jamie K DaSilva,Laura Breidenbach,Tracy Deats et al.
Jamie K DaSilva et al.
Clinical development of compounds that carry a convulsion liability is typically limited by safety margins based on the most sensitive nonclinical species. To better understand differences in sensitivity to drug-induced convulsion of common...
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability [0.03%]
利用胶原玻璃膜的一种新型微血管内皮模型及其在预测组胺诱导的微血管高通透性中的优势
Miaki Uzu,Toshiaki Takezawa
Miaki Uzu
Introduction: The evaluation of microvascular permeability is crucial for drug development. Nonetheless, there are few reliable test methods in vitro due to the lack of vascular endothelial models suitable for quantitativ...
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods [0.03%]
使用单细胞RNA测序方法对iCell心肌细胞进行特征分析
Christina Schmid,Christian T Wohnhaas,Tobias Hildebrandt et al.
Christina Schmid et al.
Introduction: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are being evaluated for their use in pharmacological and toxicological testing, particularly for electrophysiological side effects. However,...