A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity [0.03%]
A/J小鼠比C57BL/6小鼠更容易发生乙酰氨基酚致肝毒性
Lorena Bavia
Lorena Bavia
Acetaminophen (APAP) is commonly used to treat fever and pain. However, when in overdose is the predominant cause of hepatotoxicity. Despite advances in understanding the mechanisms of APAP-induced hepatotoxicity, the management of acute li...
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents [0.03%]
鼓励在非啮齿动物心血管遥测记录期间采用社交住房的策略
Helen Prior,Mark Holbrook
Helen Prior
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is working with industry to promote social housing during cardiovascular telemetry recordings within non-rodent safety pharmacology and toxicol...
An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts [0.03%]
一种用于检测反应性氧物种介导的半胱氨酸氧化的免疫印迹方法可用来鉴定红茶提取物的新颖硫保护功效
Philip C Burcham,Julie Le,Louis Ma
Philip C Burcham
Introduction: While cysteine thiol groups help to maintain the redox status of many proteins, they can be very susceptible to damaging oxidants. Despite broad interest in their antioxidant properties, whether tea polyphen...
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs [0.03%]
戈廷根迷你猪基因组集成系统转基因(GENISYST)技术用于疾病发病机制研究
Joachim Maxeiner,Rahul Sharma,Carolin Amrhein et al.
Joachim Maxeiner et al.
Göttingen Minipigs show several anatomical, physiological, and pathogenetical similarities to humans and serve an important role in translational studies for example as large animal models of disease. In recent years, the number of transge...
Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC-MS analysis [0.03%]
一种用于从人体生物流体中提取和预浓缩氯喹磷酸盐并在气相色谱-质谱分析前的简单快速分析方法的研究开发
Süleyman Bodur,Sezin Erarpat,Ömer Tahir Günkara et al.
Süleyman Bodur et al.
A vortex assisted spraying based fine droplet formation liquid phase microextraction (VA-SFDF-LPME) method was developed to determine chloroquine phosphate at trace levels in human serum, urine and saliva samples by gas chromatography-mass ...
Ruth Stow,John Kendrick,Neil Ibbotson et al.
Ruth Stow et al.
Understanding the absorption, distribution, metabolism and excretion (ADME) of candidate drugs in preclinical species is an integral part of the safety and efficacy evaluation in drug development. For this purpose, the housing of single ani...
Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies [0.03%]
花生酱作为剂量输送替代方法预防应激对小鼠致畸试验的影响研究
Melanie R Warren,Andreea Radulescu,Peter Dornbos et al.
Melanie R Warren et al.
Introduction: Animal-based studies are essential for assessing toxicity to environmental pollutants, especially when the potential targets are specific developmental time points, teratogenic, or multi-organ systems that c...
LC-MS/MS method for rapid and accurate detection of caffeine in a suspected overdose case [0.03%]
疑似咖啡因中毒案的快速准确检测液相色谱-串联质谱方法
Kiyotaka Usui,Yuji Fujita,Yoshito Kamijo et al.
Kiyotaka Usui et al.
Excessive intake of caffeine, otherwise known to be a safe and mild central nervous system stimulant, causes nausea, vomiting, convulsions, tachycardia, and eventually fatal arrhythmias and death. Caffeine intoxication, a global problem, ha...
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS [0.03%]
液相色谱-串联质谱法同时测定全血中磷脂乙醇16:0/18:1以及八类药物共33种化合物
Benedicte Jørgenrud,Eline Skadberg,Julio de Carvalho Ponce et al.
Benedicte Jørgenrud et al.
Introduction: Most bioanalytical LC-MS/MS methods are developed for determination of single drugs or classes of drugs, but a multi-compound LC-MS/MS method that can replace several methods could reduce both analysis time ...
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model [0.03%]
用于评估猪模型中重组人透明质酸酶PH20介导的皮下给药弥散的断层扫描法
Robert J Connor,Darin M Taverna,Karla Thrall et al.
Robert J Connor et al.
Introduction: Subcutaneous (SC) formulations of therapeutics with recombinant human hyaluronidase PH20 (rHuPH20) are currently approved across various disease indications. The rHuPH20-mediated enzymatic degradation of SC ...