l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies [0.03%]
L-瓜氨酸：作为重复给药毒性试验中大鼠和狗小肠安全性的生物标志物的临床前研究
Sven Jäckel,Frederic Christian Pipp,Barbara Emde et al.
Sven Jäckel et al.
Introduction: Gastrointestinal (GI) toxicity is still an issue within drug development, especially for novel oncology drugs. The identification of GI mucosal damage at an early stage with high sensitivity and specificity ...
Justin Choi,Cameron E West,Youkyung S Roh et al.
Justin Choi et al.
Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, ...
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification [0.03%]
药物和化学致癌性检测中两年啮齿类动物致癌试验的性能、效用及配置以识别致癌危害
Jose D Suarez-Torres,Camilo A Orozco,Carlos E Ciangherotti
Jose D Suarez-Torres
For several intended uses of chemicals, the 2-year rodent bioassay (RCB) has been the benchmark method to screen the carcinogenicity to humans of substances, according to the hazard identification sphere. Despite the ongoing controversy aro...
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes [0.03%]
改良的2-NBDG测定在培养的肌管中测量葡萄糖摄取率
Manju Bala,Prachi Gupta,Sanjeev Gupta et al.
Manju Bala et al.
Under type-2 diabetes, insulin resistance develops in skeletal muscles as a key defect and to study the disorder, its manifestation, and possible solution, measurement of glucose uptake is a fundamental necessity. Of various approaches (i.e...
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies [0.03%]
体内QTc核心检测：评价QTc变异、检出敏感性以及对清醒犬和非人灵长类动物遥测研究改进的意义
Joel Baublits,Hugo M Vargas,Michael J Engwall
Joel Baublits
The ICH S7B guideline describes the requirement to conduct an in vitro IKr (hERG) and in vivo QTc assay for human risk assessment of new drug products, but the guidance is devoid of recommendations on study execution or quality. In the abse...
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins [0.03%]
犬类遥测研究中自动血液采样的应用：增强心血管风险和安全范围评估能力
Yevgeniya E Koshman,Amanda S Wilsey,Brandan M Bird et al.
Yevgeniya E Koshman et al.
Introduction: A successful integration of automated blood sampling (ABS) into the telemetry instrumented canine cardiovascular model is presented in this study. This combined model provides an efficient means to quickly g...
Cell-based actin polymerization assay to analyze chemokine inhibitors [0.03%]
基于细胞的.actin.聚合化测定用于分析趋化因子抑制剂
Victoria I Engemann,Ina Rink,Michelle F Kilb et al.
Victoria I Engemann et al.
Chemokines play an important role in various diseases as signaling molecules for immune cells. Therefore, the inhibition of the chemokine-receptor interaction and the characterization of potential inhibitors are important steps in the devel...
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin [0.03%]
一种新的博来霉素诱导的小鼠肺纤维化模型：血小板在慢性肺纤维化发病机制中的作用
R Carrington,S Jordan,Y J Wong et al.
R Carrington et al.
Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and destruction of lung tissue that is ultimately fatal. There is a need to develop improved treatments for IPF. One problem with identifying novel treatments of IPF is t...
Core battery safety pharmacology testing - An assessment of its utility in early drug development [0.03%]
核心电池安全药理学检测在早期药物研发中的应用价值评估
Paul Baldrick
Paul Baldrick
Requirements for safety pharmacology testing have been in place since the issue of initial regulatory guidance over 20 years ago. An evaluation of such testing, supporting first clinical entry of 105 small molecule drug candidates over the ...
Christina Karamani,Ivi Theodosia Antoniadou,Aikaterini Dimou et al.
Christina Karamani et al.
Introduction: Psoriasis, is a common, chronic, autoimmune, inflammatory, relapsing disease, which would benefit from reliable and human-relevant animal models to test drugs pre-clinically and to understand their mechanism...