Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy [0.03%]
用于疼痛性糖尿病神经病研究的实验模型诱导剂选择：alloxan比streptozotocin更好
Paulla Vieira Rodrigues,Bruna Moreira Silva Lemos,Maria Vitoria da Silva et al.
Paulla Vieira Rodrigues et al.
Previous data indicate that the diabetogenic substance streptozotocin might act in nociceptive neurons changing the sensory signal, regardless of hyperglycemia. In the present article the effects of streptozotocin were compared with another...
Adela Krivohlavek,Željka Kuharić,Ana Marija Marjanović Čermak et al.
Adela Krivohlavek et al.
The aim of the study was to develop fast and accurate method for assessment of intracellular level of cadmium (Cd) and thallium (Tl), and to establish accumulation of the metals in the cells. HepG2 cells were treated with Cd or Tl (1.0 or 1...
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients [0.03%]
监督机器学习的急性细胞压力筛选可预测辅料的细胞毒性
Andrew A Bieberich,Bartek Rajwa,Allison Irvine et al.
Andrew A Bieberich et al.
Excipients serve as vehicles, preservatives, solubilizers, and colorants for drugs, food, and cosmetics. They are considered to be inert at biological targets; however, several reports suggest that some could interact with human targets and...
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model [0.03%]
癫痫诱发的尖端扭转型室速：一个由药物诱导的犬类LQT1模型中的现象
Henk van der Linde,Mohamed Kreir,Ard Teisman et al.
Henk van der Linde et al.
Introduction: People with epilepsy are at heightened risk of sudden death compared to the general population. The leading cause of epilepsy-related premature mortality is a sudden unexpected death in epilepsy (SUDEP). The...
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice [0.03%]
新的体内和体外混合活体成像系统（IVIS）成像为测量清醒小鼠的肾小球滤过率提供了一种便捷精确的方法
Seo-Kyoung Hwang,Cheryl Tyszkiewicz,Jeffrey Morin et al.
Seo-Kyoung Hwang et al.
Introduction: In pharmacology and toxicology studies, the glomerular filtration rate (GFR) is the gold standard for the assessment of renal function, and the renal clearance of inulin in blood measured by photometers is k...
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes [0.03%]
人诱导多能干细胞肝细胞系作为肝功能和毒性模型的特征描述用于监管目的
Hisham Qosa,Alexandre J S Ribeiro,Neil R Hartman et al.
Hisham Qosa et al.
It has recently become possible to produce hepatocytes from human induced pluripotent stem cells (iPSC-heps), which may offer some advantages over primary human hepatocytes (Prim-heps) in the regulatory environment. The aim of this research...
Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays [0.03%]
验证使用心脏停搏液保存兔心室肌条分离灌流模型心脏功能的方法
Ziva Arimura,BaoXi Gao,Mei Fang et al.
Ziva Arimura et al.
Introduction: Cardioplegic solutions were first developed to preserve heart function during cardiac surgeries and heart transplants but have application in the nonclinical setting. Due to lack of lab space in the vivarium...
A stable cell line inducibly expressing hERG1a/1b heteromeric channels [0.03%]
一种可诱导表达hERG1a/1b异源二聚体通道的稳定细胞系
Erick B Ríos-Pérez,Fang Liu,Whitney A Stevens-Sostre et al.
Erick B Ríos-Pérez et al.
Heterologously expressed hERG channels represent a mainstay of in vitro drug safety screens intended to mitigate risk of cardiac IKr block and sudden cardiac death. This is true even as more channel types are adopted as part of the Comprehe...
Study design criteria for regulatory-based drug control action: Drug discrimination [0.03%]
基于监管的药物控制行动的研究设计标准：药物鉴别
David V Gauvin,Zachary J Zimmermann
David V Gauvin
This "methods paper" focusses on one specific and limited aspect of drug safety evaluations required for all new drug entities that affect the central nervous system - the drug discrimination (DD) assay. We focus on three critical factors i...
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives [0.03%]
自动化补片钳技术在心脏安全评估中的应用：过去、现在和未来展望
Damian C Bell,Bernard Fermini
Damian C Bell
There is no doubt that automated patch clamp (APC) technology has revolutionized research in biomedical science. High throughput ion channel screening is now an integral part of the development and safety profiling of the majority of new ch...