A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability [0.03%]
基于人群的体外心脏毒性的分级方法：估计毒性作用强度与变异性之间的权衡
Alexander D Blanchette,Sarah D Burnett,Ivan Rusyn et al.
Alexander D Blanchette et al.
Population-wide in vitro studies for characterization of cardiotoxicity hazard, risk, and population variability show that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a powerful and high-throughput testing plat...
Use of subcutaneous transponders to monitor body temperature in laboratory rats [0.03%]
实验室大鼠皮下植入传感器监测体温的使用及其评价
Alejandro M Pato,Delfina M Romero,Carla S Sosa Holt et al.
Alejandro M Pato et al.
Implantable radiofrequency transponders may be adequate for the characterization of hazardous chemicals targeting body temperature control in experimental animals when colonic probes and automated monitoring systems based on intraperitoneal...
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model [0.03%]
高脂饮食喂养和低剂量链脲佐菌素诱导的Wistar大鼠糖尿病模型的生化特征分析
Akurange Sujeevi D Wickramasinghe,Anoja P Attanayake,Pabasara Kalansuriya
Akurange Sujeevi D Wickramasinghe
The development of a stable disease model with an adequate biochemical profile is crucial for the preclinical investigation of new antidiabetic agents. This study aimed at optimization and characterization of high fat diet (HFD) fed strepto...
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis [0.03%]
一种快速分光光度法识别人类红细胞生成抑制剂的方法
Denise P Ilboudo,Sarah D&#x;Alessandro,Silvia Parapini et al.
Denise P Ilboudo et al.
Erythropoiesis is a complex physiological process by which erythroid progenitors proliferate and differentiate into nonnucleated red blood cells. Several methods can be used to monitor in vitro the differentiation of erythroid precursors, a...
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs [0.03%]
豚鼠组胺诱导过敏性结膜炎模型的优化
Hidemi Mochizuki,Susumu Suyama,Joo Young Cha et al.
Hidemi Mochizuki et al.
Allergic conjunctivitis is one of the most common immune diseases in the field of ophthalmology. The number of patients suffering from allergic conjunctivitis has been increasing, and there is still a strong need for development of therapeu...
Fluorescent opioid receptor ligands as tools to study opioid receptor function [0.03%]
荧光阿片受体配体作为研究阿片受体功能的工具
Despina Giakomidi,Mark F Bird,Remo Guerrini et al.
Despina Giakomidi et al.
Opioid receptors are divided into the three classical types: MOP(μ:mu), DOP(δ:delta) and KOP(κ:kappa) that are naloxone-sensitive and an additional naloxone-insensitive nociceptin/orphanin FQ(N/OFQ) peptide receptor(NOP). Studies to dete...
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties [0.03%]
RPMI 2650细胞层与羊鼻腔上皮组织在鼻腔给药和免疫细胞化学性质上的比较研究
Werner Gerber,Hanna Svitina,Dewald Steyn et al.
Werner Gerber et al.
Nasal drug administration has been identified as a potential alternative to oral drug administration, especially for systemic delivery of large molecular weight compounds. Major advantages of nasal drug delivery include high vascularity and...
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC-MS [0.03%]
硫酸羟氯喹的一步衍生化及分散液液微萃取并用GC-MS进行灵敏准确测定
Süleyman Bodur,Sezin Erarpat,Ömer Tahir Günkara et al.
Süleyman Bodur et al.
In the present study, a novel analytical method for the determination of hydroxychloroquine sulfate in human serum and urine samples was established. One step derivatization and dispersive liquid-liquid microextraction (DLLME) was developed...
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands [0.03%]
脑源性神经营养因子用于高通量评估选择性的Sigma-1受体配体
Dhwanil A Dalwadi,Stephanie Kim,John Schetz et al.
Dhwanil A Dalwadi et al.
The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treatin...
Alexander A Andreev-Andrievskiy,Evgeniya A Lagereva,Nadezda V Pankova et al.
Alexander A Andreev-Andrievskiy et al.
Metabolic chambers are routinely used for urine collection in rodents. In mice, due to small urination volume, evaporation in the metabolic chambers (≈50%) distorts diuresis and urinalysis parameters. We have developed a new technique of b...