The chicken embryo model as a tool for investigating drug-induced acute kidney injury [0.03%]
鸡胚模型作为研究药物引起的急性肾损伤的工具
Murillo D L Bernardi,Krista den Ouden,Melanie Nieuwenhuijzen-Van de Kaa et al.
Murillo D L Bernardi et al.
Nephrotoxicity remains a critical concern in drug development, with limited preclinical models that balance physiological relevance, ethical considerations, and scalability. Here, we evaluate the chicken embryo (CE) as an in vivo platform f...
Yong Wu,Huiqi Zhang,Fengnian Sun et al.
Yong Wu et al.
Oxidative stress is a key driver of heart disease, but existing single-cell models lack the complexity of cardiac tissue. Developing advanced in vitro systems is therefore critical. This study aimed to develop a zebrafish heart oxidative st...
Analytical method validation with development for the detection and quantification of kratom alkaloids using LC - MS/MS [0.03%]
用于检测和定量使用LC-MS / MS的 kratom生物碱的分析方法开发与验证
Md Harunur Rashid,Conor O&#x;Croinin,Tyson S Le et al.
Md Harunur Rashid et al.
Purpose: In this investigation, a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was designed both to develop and to detect kratom alkaloids that are naturally occurring organic compounds...
Effects of alendronate and vitamin D on plasma metabolomic profiles in a rat model of osteoporosis [0.03%]
阿仑膦酸钠和维生素D对骨质疏松症大鼠血浆代谢谱的影响
Amel Hamza,David Wishart,Michael R Doschak
Amel Hamza
Background: Osteoporosis is a progressive bone disease and a significant global health issue, which places a serious economic and health burden on families and societies. Nitrogenated bisphosphonate drugs remain the first...
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends [0.03%]
非临床心血管安全性试验：现状、不足与趋势展望
Peter Hoffmann,Michael K Pugsley
Peter Hoffmann
Cardiovascular adverse drug reactions remain a leading cause of drug attrition. They may emerge during non-clinical or clinical development and often remain undetected until post-marketing, prompting increased regulatory focus. Historically...
Corrigendum to 'PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks' [Journal of pharmacological and toxicological methods 136 (2025) 108393] [0.03%]
“PolyCheck：一种使用异构药物-靶点-ADR网络预测结核病治疗中多药相互作用引起的不良反应的混合模型”的勘误表
Ahmad Tamim Ghafari,Yuslina Zakaria,Mizaton Hazizul Hasan et al.
Ahmad Tamim Ghafari et al.
A novel, flexible, and accessible method for the ex vivo induction and quantification of excitotoxicity [0.03%]
一种新颖、灵活且易于使用的体外诱导和量化兴奋毒性方法
Samantha J Carew,Christiana M Kennedy,Meghan L Greenland et al.
Samantha J Carew et al.
Excitotoxicity is a key driver of neuronal death in diverse brain conditions, yet most toxicity assays rely on in vitro models that remove cells from their complex native environment within the brain parenchyma. Here, we present a novel ex ...
LC-MS/MS-based simultaneous quantification of chlorthalidone and cilnidipine in rat plasma: Pharmacokinetic evaluation, green analytical assessment, and DoE-driven optimization [0.03%]
基于LC-MS/MS的定量分析氯噻酮和尼群地平在大鼠血浆中的药动学评估、绿色分析评估和DoE驱动优化
Sravanthi Gandu,Kumaraswamy Gandla,Lalitha Repudi
Sravanthi Gandu
A highly sensitive and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was systematically developed and optimized using a Quality by Design (QbD) framework for the simultaneous quantification of chlorthalidone ...
Optimization strategy for modeling sick sinus syndrome in rats: Balancing effect and animal care [0.03%]
一种优化的大鼠病态窦房结综合征建模策略：在疗效和动物护理之间求平衡
Liming He,Xinxin Shi,Yucheng Wang et al.
Liming He et al.
Objective: This study aimed to validate the feasibility of establishing a sick sinus syndrome (SSS) rat model by injecting 3 % sodium hydroxide (NaOH) into the jugular vein at a rate of 0.01 mL/s, and to assess reductions...
Corrigendum to "Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As" [J. Pharmacol. Toxicol. Methods 123 (2023) 107270] [0.03%]
关于“非啮齿类动物品种中用于ICH E14/S7B Q&As的非临床在体心血管遥测研究的最佳实践考虑：提供高质量的QTc数据”(J. Pharmacol. Toxicol. Methods 123 (2023) 107270)的勘误表
Eric I Rossman,Todd A Wisialowski,Hugo M Vargas et al.
Eric I Rossman et al.