An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds [0.03%]
基于五种参比化合物的体内犬研究的药代动力学-心血管生理模型集成方法
Mikael Wallman,Jens Markus Borghardt,Eric Martel et al.
Mikael Wallman et al.
Cardiovascular (CV) effects represent a major safety issue during drug development. Typically, this risk is mitigated by preclinical in vivo CV studies, based on which measured CV readouts are analyzed independently. Here, we apply a regres...
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry [0.03%]
一种用于检测人血清和尿液中左旋甲状腺素及其类似物的液相色谱-三重四级杆质谱测定方法的优化
Dayamin Martínez Brito,Patrizia Leogrande,Xavier de la Torre et al.
Dayamin Martínez Brito et al.
Thyroid hormones and their derivatives are structurally related to the non-essential amino acid tyrosine (4-hydroxyphenylalanine). However, there are physicochemical differences that make it difficult to apply an analytical method for their...
Do behavioral test scores represent repeatable phenotypes of female mice? [0.03%]
行为检测得分可以代表小鼠的可重复表型吗？
Nadav Menashe,Youstina Salama,Michelle L Steinauer et al.
Nadav Menashe et al.
The marble bury test is a commonly applied behavioral test often used to screen pharmaceuticals for treatment of compulsivity or anxiety disorders and to better understand the underlying neurobiology of these conditions using rodent models....
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia [0.03%]
telemetry血压发射器在小 Gottingen 猪中的植入：24小时全身血压和心率监测的验证及麻醉的影响
Michelle Fischer Carlsen,Berit Østergaard Christoffersen,Rikke Lindgaard et al.
Michelle Fischer Carlsen et al.
Introduction: Porcine animal models are used in biomedical research due to anatomical and physiological similarities with human patients. The study aimed to validate telemetric systemic blood pressure (BP) and heart rate ...
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species [0.03%]
非临床抗心律失常药物的非临床心血管安全性评估：自主神经张力、体温和实验动物选择的影响
Andrea Greiter-Wilke,Sonia Roberts,Katja Heinig et al.
Andrea Greiter-Wilke et al.
Pending updates to ICH S7B/E14 guidelines will enable the substitution of human TQT studies with support from concomitant negative hERG and non-rodent CV studies. This retrospective analysis compared the effects of thioridazine (THD) (5-20 ...
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models [0.03%]
基于创伤性脑损伤的体外小鼠神经元及脑内皮细胞模型研究
Luise J Meyer,Felicia P Lotze,Matthias L Riess
Luise J Meyer
Traumatic brain injury can lead to fatal outcomes such as disability and death. Every year, it affects many patients all over the world. Not only the primary ischemic event, but also the subsequent reperfusion can cause severe brain injury....
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells [0.03%]
高内涵分析和动力学影像细胞计数识别HIV抗逆转录病毒药物对人类iPSC-神经元和原代神经前体细胞的毒性及表观遗传影响
Alyson S Smith,Soneela Ankam,Chen Farhy et al.
Alyson S Smith et al.
Introduction: Despite viral suppression due to combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders (HAND) continue to affect half of people with HIV, suggesting that certain antiretrovirals ...
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin [0.03%]
一种从实验小鼠中获取母乳的非侵入性方法——催产素合成类似物卡贝托奥汀的应用研究
Pavel Klein,Ivana Kleinova,Vaclav Rucka et al.
Pavel Klein et al.
Introduction: The mouse is an important laboratory animal in pharmacological and toxicological research. However, there is a limited ability to analyse the penetration of tested substances in mouse breastmilk, which is te...
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy [0.03%]
优化的小鼠气管内给药方法的建立及验证研究
Charlotte E Pelgrim,Ingrid van Ark,Thea Leusink-Muis et al.
Charlotte E Pelgrim et al.
Animal models are still vital in the field of respiratory disease research. To improve the accuracy and consistency of the dose of specific compounds administered specifically in the respiratory tract, it is important to optimize and to com...
Jeremy D Ollerenshaw,Malene Schrøder,Sten Velschow
Jeremy D Ollerenshaw
Diagnostic serial venous blood sampling has the potential to introduce stress-related artifactual elements into the analytical results. We have evaluated the use of a wearable automated serial blood sampling device in a canine model that ob...