A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats [0.03%]
心血管遥测研究与Wistar Han大鼠定量开放式运动场行为学研究生成的活动数据比较
Cheryl Tyszkiewicz,Vincent Bernardo,Siddhartha Bhatt et al.
Cheryl Tyszkiewicz et al.
Compound-mediated locomotion changes, conducted via open field infrared photobeam breaks, are an important common component of neurological assessments conducted in safety pharmacology studies. In addition to open field locomotor activity a...
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine in human urine and serum samples by gas chromatography mass spectrometry [0.03%]
结合四极杆同位素稀释质谱、同时衍生化及喷雾辅助微液滴形成-液相微萃取的毛细管气相色谱法测定人尿和血样中的甲基苯丙胺
Sude Oflu,Sezin Erarpat,Buse Tuğba Zaman et al.
Sude Oflu et al.
In this study, an analytical method with high accuracy and precision was developed for the determination of methamphetamine in human urine and serum samples by gas chromatography-mass spectrometry (GC-MS). A simultaneous derivatization and ...
Analysis of secondary pharmacology assays received by the US Food and Drug Administration [0.03%]
美国食品和药物管理局接收的二线药物作用分析
Christina Scott,Andrew Dodson,Muriel Saulnier et al.
Christina Scott et al.
Secondary pharmacology studies are a time-efficient and cost-effective method for determining the safety profile of a potential new drug before it enters human trials. The results of these multi-target screens are commonly submitted with In...
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment [0.03%]
2022年的安全药理学：心血管安全性评价向前迈出了一小步，但监管药物安全性评估向前迈进了一大步
Michael K Pugsley,Yevgeniya E Koshman,Tessa de Korte et al.
Michael K Pugsley et al.
The 2021 Annual Safety Pharmacology (SP) Society (SPS) meeting was held virtually October 4-8, 2021 due to the continuing COVID-19 global pandemic. This themed issue of J Pharmacol Toxicol Methods comprises articles arising from the meeting...
Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus) [0.03%]
新西兰白兔(Oryctolagus cuniculus)单笼和双笼饲养的学习程序效应的测定方法
Rosemary V Santos,Siddhartha Bhatt,Stephen Foote et al.
Rosemary V Santos et al.
Social housing of laboratory rabbits is encouraged and thought to improve animal welfare due to the social nature of this species. However, there is limited published information comparing the physiologic and cardiovascular (CV) effects of ...
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs [0.03%]
实验性IV型过敏性结膜炎的动物模型及机制研究进展
Hidemi Mochizuki,Susumu Suyama,So-Young Youm et al.
Hidemi Mochizuki et al.
Histamine is strongly associated with the onset of allergic conjunctivitis. The most recent cloned histamine H4 receptor antagonist is highly expected as a new therapeutic drug candidate. As a model for a therapeutic drug targeting the hist...
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss [0.03%]
根据ICHE14/S7BQ&As最佳实践获得的五种阳性对照药物的hERG阻滞活性：记录温度和药物损失的影响
Claudia Alvarez Baron,Nicolas Thiebaud,Ming Ren et al.
Claudia Alvarez Baron et al.
According to the ICH S7B guideline, drug candidates are screened for hERG block prior to first-in-human testing to predict the likelihood of delayed repolarization associated with a rare, but life-threatening, ventricular tachyarrhythmia. T...
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain [0.03%]
用于大鼠脑同一部位电刺激和药物递送的双极电极 cannula 组件的内部制造方法
Amit G Choudhary,Sanjay N Awathale,Nishikant K Subhedar et al.
Amit G Choudhary et al.
Strategies drawn at understanding the functional attributes of specific neural circuits often necessitate electrical stimulation and pharmacological manipulation at the same anatomical site. We describe a simple, inexpensive and reliable me...
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system [0.03%]
利用DECRO系统在群居大鼠中进行非侵入式夹克遥测联合评估呼吸系统、心电图和活动状况
Raafat Fares,Timothé Flénet,Jonathan Vial et al.
Raafat Fares et al.
Respiratory and cardiovascular systems are among the vital organ systems that should be studied in safety pharmacology core battery test. Non-invasive jacketed external telemetry technology that enables concomitant monitoring of both system...
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system [0.03%]
一种新的利用ELP-Intein系统净化血管紧张素转换酶催化位点N域的方法
Carolina Machado Dos Santos,Suelen de Barros Sampaio,Fagner Santana et al.
Carolina Machado Dos Santos et al.
Angiotensin-converting enzyme I (ACE) is a key part of the renin-angiotensin system. Its main function is to regulate blood pressure and the balance of salts in the body. Somatic ACE has two domains, N-C-, each of which has a catalytic site...