Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons [0.03%]
从Ixodes ricinus分离和进行神经元电生理记录
Khalid Boussaine,Maria Taha,Cáinà Nìng et al.
Khalid Boussaine et al.
The central nervous system of hard ticks (Ixodidae) consists of a concentrated merged nerve mass known as the synganglion. Although knowledge of tick neurobiology has dramatically improved over the last two decades, this is the first time t...
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates [0.03%]
荧光法和乳酸脱氢酶测定法检测恶性疟原虫田间标本的抗疟活性比较研究
Joseph Hawadak,Shewta Chaudhry,Veena Pande et al.
Joseph Hawadak et al.
Several assay methods are in use for monitoring the drug sensitivity of malaria parasites and screening new antimalarial drugs. Plasmodium lactate dehydrogenase (pLDH) and SYBR Green I in vitro assays were used to evaluate the drug efficacy...
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys [0.03%]
基于计算机的半自动分析长程心电图中恒河猴室性心律失常性能和可行性的三种不同方法
Jörg Eiringhaus,Anna-Lena de Vries,Stephan Hohmann et al.
Jörg Eiringhaus et al.
Computer-based analysis of long-term electrocardiogram (ECG) monitoring in animal models represents a cost and time-consuming process as manual supervision is often performed to ensure accuracy in arrhythmia detection. Here, we investigate ...
Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay [0.03%]
用电化学发光法测定猴子和人类血液中抗fractalkine单克隆抗体E6011的抗体药物量化值
Muneo Aoyama,Yuji Mano
Muneo Aoyama
E6011, a humanized anti-fractalkine monoclonal antibody, is under development for the treatment of various inflammatory diseases, such as rheumatoid arthritis. Therapeutic antibodies may induce production of anti-drug antibodies (ADA) that ...
Adaptation of closed-chest infarction porcine model to adult Pannon minipigs [0.03%]
闭胸心梗猪模型在成人蓬农迷你猪中的改良应用研究
Dénes Kőrösi,András Vorobcsuk,Dániel Fajtai et al.
Dénes Kőrösi et al.
The aim of the recent study was to collect data on the genotype characteristics of the Hungarian self-bred Pannon minipigs by adapting a standardized infarct model procedure. Closed chest AMI was induced by balloon occlusion for 90 min in t...
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects [0.03%]
脱靶药理活性在各种激酶中的作用：潜在的功能和病理副作用
Jonathon R Green,Prathap Kumar S Mahalingaiah,Sujatha M Gopalakrishnan et al.
Jonathon R Green et al.
In drug discovery, during the lead optimization and candidate characterization stages, novel small molecules are frequently evaluated in a battery of in vitro pharmacology assays to identify potential unintended, off-target interactions wit...
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document [0.03%]
2023年安全药理学及ICH E14/S7B问答文件实施研讨会
Michael K Pugsley,Yevgeniya E Koshman,C Michael Foley et al.
Michael K Pugsley et al.
This editorial prefaces the annual themed issue on safety pharmacology (SP) methods published since 2004 in the Journal of Pharmacological and Toxicological Methods (JPTM). We highlight here the content derived from the recent 2022 Safety P...
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability [0.03%]
IMI2-神经风险药物致癫痫副作用的微电极阵列去风险研究比较研究报告
Jin Zhai,Martin Traebert,Kurt Zimmermann et al.
Jin Zhai et al.
Introduction: In the framework of the IMI2-NeuroDeRisk consortium, three in vitro electrophysiology assays were compared to improve preclinical prediction of seizure-inducing liabilities. ...
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates [0.03%]
卡托普利试验的交叉设计和并列设计的敏感性比较：基于48只非人灵长类动物的数据分析
Derek J Leishman,David L Holdsworth,Derek D Best et al.
Derek J Leishman et al.
The cardiovascular safety pharmacology (SP) study conducted to satisfy ICH S7A and S7B has commonly used a cross-over study design where each animal receives all treatments. In an increasing number of cases, cross-over designs are not possi...
Elham Ataei Alizadeh,Georg Rast,Chris Cantow et al.
Elham Ataei Alizadeh et al.
Introduction: Pharmacokinetic/pharmacodynamic modelling has emerged as a valuable technique for understanding drug exposure and response relationships in drug development. Pharmacokinetic data are often obtained by taking...