Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog [0.03%]
麻醉狗多心血管调节机制移植的评价
Olivera Antic,Yevgeniya E Koshman,Brandan M Bird et al.
Olivera Antic et al.
The strategic and targeted use of an anesthetized canine cardiovascular model early in drug discovery enables a comprehensive cardiovascular and electrophysiological assessment of potential safety liabilities and guides compound selection p...
Virtual clinical QT exposure-response studies - A translational computational approach [0.03%]
虚拟临床QT暴露反应研究-一种转化计算方法
Jazmin Aguado-Sierra,Paula Dominguez-Gomez,Ani Amar et al.
Jazmin Aguado-Sierra et al.
Background and purpose: A recent paradigm shift in proarrhythmic risk assessment suggests that the integration of clinical, non-clinical, and computational evidence can be used to reach a comprehensive understanding of th...
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration [0.03%]
通过脑室内药物给药后结合大鼠海马脑片电生理与体内行为观察来改进癫痫发生的检测
Tadashi Tsubouchi,Keigo Ikeda,Yasuhiro Sasaki et al.
Tadashi Tsubouchi et al.
An adverse effect of drug candidates, seizure is a serious issue in drug development. Improving evaluation systems for seizure liability is crucial for selecting good candidates. Firstly, in vitro electrophysiological measurement by a multi...
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals [0.03%]
视野测试迷宫和视力迷宫：可用于评估动物视野损失的可行技术
Shivani Behera,Ashmita Das,Jaya Shree et al.
Shivani Behera et al.
Visual field loss due to glaucoma is a severe and concerning problem, leading to limited visual range and poor quality vision. The progression of this loss begins with a para-central arcuate scotoma which eventually advances to a ring scoto...
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods [0.03%]
《药理学与毒理学方法杂志》23年的个人回顾
Michael J Curtis
Michael J Curtis
A highly efficient liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney [0.03%]
尿液、肝脏和肾脏中依托咪酯和依托咪酯酸的一种高效液相色谱串联质谱(LC-MS/MS)检测方法
Tian-Fu He,Huan-Hui Zhu,Xian-Wen Lin et al.
Tian-Fu He et al.
Etomidate (ETO) is a highly-efficient drug that can induce anesthesia with increasing doses, thus subject to strict regulation. However, an accurate and efficient method for ETO intake detection is currently lacking. Therefore, this study d...
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma [0.03%]
简易分光光度法测定血浆水杨酸盐的验证研究
Younes Zebbiche,Abderrahmane Kori Yahia,Nour El Yakine Keraghel et al.
Younes Zebbiche et al.
Introduction: The determination of salicylate concentrations constitutes a critical aspect of medical diagnostics, particularly in emergency settings. High-performance liquid chromatography (HPLC) and spectrophotometry ar...
Telemetric long-term assessment of autonomic function in experimental heart failure [0.03%]
实验性心力衰竭长期自主神经功能的遥测评估
Katharina Boden,Pailin Pongratanakul,Julia Vogel et al.
Katharina Boden et al.
Despite medical advances in the treatment of heart failure (HF), mortality remains high. It has been shown that alterations of the autonomic-nervous-system (ANS) are associated with HF progression and increased mortality. Preclinical models...
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis [0.03%]
一种广义犬模型传递函数可准确重构主动脉压力波形以实现增强的脉搏波分析
Julia C Hotek,Theodore J Detwiler,Julio A Chirinos et al.
Julia C Hotek et al.
Routine preclinical blood pressure evaluation is an important risk assessment tool. Although proximal aortic pressure is most relevant for key target organs, abdominal aortic pressures are more commonly recorded. Pulse pressure amplificatio...
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress [0.03%]
人骨髓间充质/基质干细胞和人类A549肺癌细胞经冻融处理后多种细胞活力测定方法的比较
Markus Kardorff,Hanns-Christian Mahler,Jörg Huwyler et al.
Markus Kardorff et al.
For the safety and efficacy of frozen cell therapy products, determination of cellular viability is key. However, results of cell viability measurements do not only depend on the cell line or on the inflicted stress, but also on the assay u...